STRINGSTRING
Fbxl13 Fbxl13 Spsb2 Spsb2 Fbxl8 Fbxl8 Siah1 Siah1 Fbxo39 Fbxo39 Cks2 Cks2 Spsb4 Spsb4 Fbxo2 Fbxo2 Fbxo6 Fbxo6 Fbxo9 Fbxo9 Cul5 Cul5 Fbxo32 Fbxo32 Cul1 Cul1 Fbxo7 Fbxo7 Cacybp Cacybp Fbxl18 Fbxl18 Fbxl19 Fbxl19 Skp2 Skp2 Spsb1 Spsb1 Cul2 Cul2 Fbxl21 Fbxl21 Skp1 Skp1 Fbxl3 Fbxl3 Nccrp1 Nccrp1 Fbxo45 Fbxo45 Fbxl4 Fbxl4 Fbxw11 Fbxw11 Fbxw8 Fbxw8 Usp47 Usp47 Pnkp Pnkp Rbx1 Rbx1 Fbxo42 Fbxo42 Fbxl5 Fbxl5 Tmem183a Tmem183a Fbxw4 Fbxw4 M0RA85_RAT M0RA85_RAT LOC100911548 LOC100911548 Fbxl17 Fbxl17 Fbxo31 Fbxo31 D3ZGT4_RAT D3ZGT4_RAT Fbxo25 Fbxo25 Fbxl12 Fbxl12 Spsb3 Spsb3 Fbxl20 Fbxl20 Ccnf Ccnf Fbxo44 Fbxo44 Daw1 Daw1 Lrrc29 Lrrc29 Fbxo33 Fbxo33 Fbxo15 Fbxo15 Cks1b Cks1b Amn1 Amn1 Fbxw7 Fbxw7 F1M990_RAT F1M990_RAT Fbxl16 Fbxl16 Fbxl6 Fbxl6 Fbxo48 Fbxo48 Fbxl7 Fbxl7 Fbxl2 Fbxl2 Fbxw5 Fbxw5 Dmac2 Dmac2 Fbxo17 Fbxo17 Fbxl15 Fbxl15 Fbh1 Fbh1 Trim21 Trim21 Fbxl22 Fbxl22 Btrc Btrc Fbxo4 Fbxo4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Fbxl13F-box and leucine-rich repeat protein 13. (590 aa)
Spsb2SPRY domain-containing SOCS box protein 2; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). (264 aa)
Fbxl8Similar to F-box and leucine-rich repeat protein 8 (Predicted). (374 aa)
Siah1E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin- mediated degradation of many substrates, including proteins involved in transcription [...] (282 aa)
Fbxo39F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (443 aa)
Cks2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
Spsb4SplA/ryanodine receptor domain and SOCS box containing 4 (Predicted). (273 aa)
Fbxo2F-box only protein 2. (296 aa)
Fbxo6F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] (284 aa)
Fbxo9F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTOR [...] (435 aa)
Cul5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (855 aa)
Fbxo32F-box only protein 32; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity). (350 aa)
Cul1Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. (776 aa)
Fbxo7F-box only protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity). (522 aa)
CacybpCalcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). (229 aa)
Fbxl18F-box and leucine-rich repeat protein 18. (656 aa)
Fbxl19F-box and leucine-rich repeat protein 19. (674 aa)
Skp2S-phase kinase-associated protein 2 (P45). (423 aa)
Spsb1SplA/ryanodine receptor domain and SOCS box containing 1 (Predicted). (273 aa)
Cul2Cullin 2; Belongs to the cullin family. (745 aa)
Fbxl21F-box and leucine-rich repeat protein 21. (434 aa)
Skp1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (165 aa)
Fbxl3F-box and leucine-rich repeat protein 3, isoform CRA_a. (428 aa)
Nccrp1Similar to F-box only protein 6 (F-box/G-domain protein 2) (Predicted). (291 aa)
Fbxo45F-box/SPRY domain-containing protein 1; Component of E3 ubiquitin ligase complexes (By similarity). Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons. May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation (By similarity); Belongs to the FBXO45/Fsn family. (283 aa)
Fbxl4F-box and leucine-rich repeat protein 4 (Predicted), isoform CRA_c. (621 aa)
Fbxw11F-box and WD repeat domain-containing 11. (531 aa)
Fbxw8F-box/WD repeat-containing protein 8; Substrate-recognition component of a Cul7-RING ubiquitin- protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7- RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity). The Cul7-RING(FBXW8) complex mediates ubiquitinatio [...] (596 aa)
Usp47Ubiquitin-specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
PnkpPolynucleotide kinase 3'-phosphatase. (548 aa)
Rbx1Ring-box 1. (108 aa)
Fbxo42F-box protein 42. (717 aa)
Fbxl5F-box and leucine-rich repeat protein 5. (690 aa)
Tmem183aTransmembrane protein 183. (401 aa)
Fbxw4F-box and WD-40 domain protein 4 (Predicted). (408 aa)
M0RA85_RATUncharacterized protein. (235 aa)
LOC100911548splA/ryanodine receptor domain and SOCS box containing 2. (264 aa)
Fbxl17F-box and leucine-rich repeat protein 17 (Predicted). (303 aa)
Fbxo31F-box only protein 31; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity); Belongs to the FBXO31 family. (507 aa)
D3ZGT4_RATCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
Fbxo25F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). (356 aa)
Fbxl12F-box and leucine-rich repeat protein 12, isoform CRA_b. (273 aa)
Spsb3SplA/ryanodine receptor domain and SOCS box containing 3 (Predicted). (391 aa)
Fbxl20F-box/LRR-repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). (436 aa)
CcnfCyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. Belongs to the cyclin family. Cyclin AB subfamily. (780 aa)
Fbxo44F-box protein 44. (255 aa)
Daw1Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly. Belongs to the WD repeat WDR69 family. (415 aa)
Lrrc29Leucine-rich repeat-containing 29. (286 aa)
Fbxo33F-box only protein 33 (Predicted). (467 aa)
Fbxo15F-box protein 15. (458 aa)
Cks1bCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
Amn1Protein AMN1 homolog; Belongs to the AMN1 family. (258 aa)
Fbxw7F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1 and probably PSEN1 (By similarity). Acts as a nega [...] (713 aa)
F1M990_RATCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
Fbxl16F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (479 aa)
Fbxl6F-box and leucine-rich repeat protein 6, isoform CRA_b. (535 aa)
Fbxo48Similar to RIKEN cDNA A630050E13 gene (Predicted). (160 aa)
Fbxl7F-box and leucine-rich repeat protein 7. (444 aa)
Fbxl2F-box and leucine-rich repeat protein 2. (438 aa)
Fbxw5F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes req [...] (569 aa)
Dmac2Distal membrane-arm assembly complex protein 2; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. (254 aa)
Fbxo17F-box only protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high- mannose glycoproteins (By similarity). (250 aa)
Fbxl15F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Required for bone mass maintenance; Belongs to the FBXL15 family. (300 aa)
Fbh1F-box only protein 18 (Predicted). (1042 aa)
Trim21Tripartite motif protein 21 (Predicted), isoform CRA_a. (471 aa)
Fbxl22Similar to F-box protein FBL2 (Predicted). (236 aa)
BtrcBeta-transducin repeat-containing E3 ubiquitin protein ligase. (587 aa)
Fbxo4F-box only protein 4 (Predicted). (431 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.