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Acan Acan Plod3 Plod3 Tgfb2 Tgfb2 Ddr2 Ddr2 Serpinf2 Serpinf2 Fmod Fmod Col3a1 Col3a1 Col5a2 Col5a2 Col1a1 Col1a1 Lum Lum Tgfbr1 Tgfbr1 Col5a1 Col5a1 Sfrp2 Sfrp2 Col1a2 Col1a2 Vps33b Vps33b Loxl4 Loxl4 Fkbp10 Fkbp10 Lmx1b Lmx1b Serpinh1 Serpinh1 Mkx Mkx Adamts12 Adamts12 Scx Scx Ext1 Ext1 Loxl1 Loxl1 Mmp11 Mmp11 Grem1 Grem1 Anxa2 Anxa2 Col11a2 Col11a2 Nf1 Nf1 Adamts7 Adamts7 Col11a1 Col11a1 Adamts14 Adamts14 Col14a1 Col14a1 P4ha1 P4ha1 Crtap Crtap Foxc2 Foxc2 Lox Lox Comp Comp Dpt Dpt P3h4 P3h4 Optc Optc LOC102555086 LOC102555086 NEWGENE_621351 NEWGENE_621351 Mia3 Mia3 Pxdn Pxdn Col2a1 Col2a1 Cyp1b1 Cyp1b1 P3h1 P3h1 Col13a1 Col13a1 Loxl2 Loxl2 Atp7a Atp7a Vipas39 Vipas39 Loxl3 Loxl3 LOC103694874 LOC103694874 Adamts2 Adamts2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AcanAggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2162 aa)
Plod3Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3; Multifunctional enzyme that catalyzes a series of post- translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosy [...] (741 aa)
Tgfb2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (442 aa)
Ddr2Discoidin domain receptor tyrosine kinase 2. (936 aa)
Serpinf2Serpin family F member 2; Belongs to the serpin family. (554 aa)
FmodFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (376 aa)
Col3a1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity). (1463 aa)
Col5a2Collagen type V alpha 2 chain. (1494 aa)
Col1a1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1453 aa)
LumLumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (338 aa)
Tgfbr1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (497 aa)
Col5a1Collagen alpha-1(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (By similarity). (1840 aa)
Sfrp2Secreted frizzled-related protein 2. (295 aa)
Col1a2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1372 aa)
Vps33bVacuolar protein sorting-associated protein 33B; May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical- basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesi [...] (617 aa)
Loxl4Lysyl oxidase-like 4 (Predicted). (758 aa)
Fkbp10Peptidylprolyl isomerase. (581 aa)
Lmx1bLIM homeobox transcription factor 1 beta. (395 aa)
Serpinh1Serpin H1; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. (417 aa)
MkxMohawk homeobox. (315 aa)
Adamts12ADAM metallopeptidase with thrombospondin type 1 motif, 12. (1599 aa)
ScxScleraxis bHLH transcription factor. (209 aa)
Ext1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
Loxl1Lysyl oxidase-like 1. (608 aa)
Mmp11Stromelysin-3; May play an important role in the progression of epithelial malignancies; Belongs to the peptidase M10A family. (491 aa)
Grem1Gremlin-1; Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed. (184 aa)
Anxa2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (339 aa)
Col11a2Procollagen, type XI, alpha 2 (Mapped). (1650 aa)
Nf1Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity (By similarity). (2808 aa)
Adamts7A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP. (1808 aa)
Col11a1Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. (1804 aa)
Adamts14ADAM metallopeptidase with thrombospondin type 1 motif, 14. (1125 aa)
Col14a1Collagen type XIV alpha 1 chain. (1794 aa)
P4ha1Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. (534 aa)
CrtapSimilar to Cartilage-associated protein (Predicted), isoform CRA_a. (209 aa)
Foxc2Forkhead box protein C2; Transcriptional activator. Might be involved in the formation of special mesenchymal tissues (By similarity). (494 aa)
LoxProtein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (411 aa)
CompCartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] (755 aa)
DptDermatopontin (Predicted), isoform CRA_a. (202 aa)
P3h4Endoplasmic reticulum protein SC65; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly; Belongs to the leprecan family. (443 aa)
OptcOpticin. (405 aa)
LOC102555086Similar to Cartilage-associated protein (Predicted), isoform CRA_b. (403 aa)
NEWGENE_621351Collagen, type I, alpha 2. (1372 aa)
Mia3Uncharacterized protein. (1377 aa)
PxdnPeroxidasin. (1475 aa)
Col2a1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1419 aa)
Cyp1b1Cytochrome P450 1B1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (By similarity). Exhibits catalytic activity for the formation of hydroxyestrogens from 17beta-estradiol (E2), namely 2- and 4-hydroxy E2. Metabolizes testosterone and progesterone [...] (541 aa)
P3h1Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity). (739 aa)
Col13a1Similar to alpha 1 type XIII collagen isoform 17, isoform CRA_a. (739 aa)
Loxl2Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys- 9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member o [...] (710 aa)
Atp7aCopper-transporting ATPase 1; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells (By similarity). (1492 aa)
Vipas39Spermatogenesis-defective protein 39 homolog; Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptio [...] (491 aa)
Loxl3Lysyl oxidase-like 3 (Predicted), isoform CRA_a. (754 aa)
LOC103694874Matrix metallopeptidase 11. (491 aa)
Adamts2ADAM metallopeptidase with thrombospondin type 1 motif, 2. (1170 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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