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Wfikkn1 Wfikkn1 Dkk1 Dkk1 LOC100910656 LOC100910656 Ly6g6d Ly6g6d Clec12b Clec12b Ly6c Ly6c Wfikkn2 Wfikkn2 Lypd1 Lypd1 Il36rn Il36rn Il1rn Il1rn Pcsk9 Pcsk9 Ly6g6g Ly6g6g Ly6e Ly6e Dut Dut Igsf1 Igsf1 Lrpap1 Lrpap1 Ccl5 Ccl5 Dkk2 Dkk2 Fst Fst LOC100912050 LOC100912050 Lilrb4 Lilrb4 Lynx1 Lynx1 Adh7 Adh7 Dkk3 Dkk3 Dkk4 Dkk4 Dkkl1 Dkkl1 LOC100911104 LOC100911104 Ly6i Ly6i Ly6h Ly6h Slurp2 Slurp2 Ncapg2 Ncapg2 RGD1565410 RGD1565410 Lypd6 Lypd6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Wfikkn1WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease- inhibitor activity (By similarity). (552 aa)
Dkk1Dickkopf WNT signaling pathway inhibitor 1. (270 aa)
LOC100910656Ly-6/neurotoxin-like protein 1-like. (111 aa)
Ly6g6dLymphocyte antigen 6 complex locus protein G6d. (134 aa)
Clec12bSimilar to macrophage antigen h (Predicted). (275 aa)
Ly6cLy6-C antigen. (134 aa)
Wfikkn2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain-containing 2. (571 aa)
Lypd1Ly6/PLAUR domain-containing protein 1; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2- containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety. (141 aa)
Il36rnInterleukin-1. (156 aa)
Il1rnInterleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity (By similarity). Belongs to the IL-1 family. (159 aa)
Pcsk9Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (691 aa)
Ly6g6gLymphocyte antigen 6 complex, locus G6G. (115 aa)
Ly6eSimilar to lymphocyte antigen 6 complex, locus E, isoform CRA_a. (136 aa)
DutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor. (205 aa)
Igsf1Immunoglobulin superfamily member 1; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B. Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription (By similarity). (1320 aa)
Lrpap1Alpha-2-macroglobulin receptor-associated protein; Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. (360 aa)
Ccl5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (92 aa)
Dkk2Dickkopf homolog 4 (Xenopus laevis) (Predicted). (259 aa)
FstFollistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). (344 aa)
LOC100912050Dickkopf homolog 1 (Xenopus laevis) (Predicted). (270 aa)
Lilrb4Leukocyte immunoglobulin-like receptor B4. (412 aa)
Lynx1Ly6/neurotoxin 1 (Predicted), isoform CRA_a. (116 aa)
Adh7All-trans-retinol dehydrogenase [NAD(+)] ADH7; Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, aldehyde and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency [...] (374 aa)
Dkk3Dickkopf WNT-signaling pathway inhibitor 3. (348 aa)
Dkk4Dickkopf WNT-signaling pathway inhibitor 4. (221 aa)
Dkkl1Dickkopf-like acrosomal protein 1. (230 aa)
LOC100911104Rat Ly6-C antigen. (134 aa)
Ly6iLymphocyte antigen 6B. (135 aa)
Ly6hLymphocyte antigen 6 family member H. (124 aa)
Slurp2Similar to secreted Ly6/uPAR related protein 2 (Predicted), isoform CRA_a. (97 aa)
Ncapg2Non-SMC condensin II complex, subunit G2. (1137 aa)
RGD1565410Similar to Ly6-C antigen gene. (111 aa)
Lypd6Ly6/PLAUR domain-containing protein 6; Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Enhances nicotine-induced Ca(2+) influx through nAChRs. Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity). (171 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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