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Dmac2 Dmac2 Fbxw5 Fbxw5 Fbxl2 Fbxl2 Fbxl7 Fbxl7 Fbxo48 Fbxo48 Fbxl6 Fbxl6 Fbxl16 Fbxl16 Fbxw7 Fbxw7 Amn1 Amn1 Fbxo33 Fbxo33 Lrrc29 Lrrc29 Fbxo44 Fbxo44 Ccnf Ccnf Fbxl20 Fbxl20 Cul4b Cul4b Fbxl13 Fbxl13 Fbxl12 Fbxl12 Fbxo31 Fbxo31 Fbxl17 Fbxl17 M0RA85_RAT M0RA85_RAT Fbxw4 Fbxw4 Fbxl5 Fbxl5 Rbx1 Rbx1 Fbxw11 Fbxw11 Fbxl4 Fbxl4 Nccrp1 Nccrp1 Fbxl3 Fbxl3 Skp1 Skp1 Fbxl21 Fbxl21 Cul2 Cul2 Skp2 Skp2 Fbxl18 Fbxl18 Cul1 Cul1 Cul5 Cul5 Fbxo9 Fbxo9 Kif14 Kif14 Fbxo6 Fbxo6 Fbxo2 Fbxo2 Fbxo39 Fbxo39 Fbxl8 Fbxl8 Fbxo4 Fbxo4 Btrc Btrc Wwtr1 Wwtr1 Fbxl22 Fbxl22 Fbxo38 Fbxo38 Fbxl15 Fbxl15 Cul4a Cul4a Fbxo17 Fbxo17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Dmac2Distal membrane-arm assembly complex protein 2; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. (254 aa)
Fbxw5F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes req [...] (569 aa)
Fbxl2F-box and leucine-rich repeat protein 2. (438 aa)
Fbxl7F-box and leucine-rich repeat protein 7. (444 aa)
Fbxo48Similar to RIKEN cDNA A630050E13 gene (Predicted). (160 aa)
Fbxl6F-box and leucine-rich repeat protein 6, isoform CRA_b. (535 aa)
Fbxl16F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (479 aa)
Fbxw7F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1 and probably PSEN1 (By similarity). Acts as a nega [...] (713 aa)
Amn1Protein AMN1 homolog; Belongs to the AMN1 family. (258 aa)
Fbxo33F-box only protein 33 (Predicted). (467 aa)
Lrrc29Leucine-rich repeat-containing 29. (286 aa)
Fbxo44F-box protein 44. (255 aa)
CcnfCyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. Belongs to the cyclin family. Cyclin AB subfamily. (780 aa)
Fbxl20F-box/LRR-repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). (436 aa)
Cul4bCullin 4B (Predicted); Belongs to the cullin family. (971 aa)
Fbxl13F-box and leucine-rich repeat protein 13. (590 aa)
Fbxl12F-box and leucine-rich repeat protein 12, isoform CRA_b. (273 aa)
Fbxo31F-box only protein 31; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity); Belongs to the FBXO31 family. (507 aa)
Fbxl17F-box and leucine-rich repeat protein 17 (Predicted). (303 aa)
M0RA85_RATUncharacterized protein. (235 aa)
Fbxw4F-box and WD-40 domain protein 4 (Predicted). (408 aa)
Fbxl5F-box and leucine-rich repeat protein 5. (690 aa)
Rbx1Ring-box 1. (108 aa)
Fbxw11F-box and WD repeat domain-containing 11. (531 aa)
Fbxl4F-box and leucine-rich repeat protein 4 (Predicted), isoform CRA_c. (621 aa)
Nccrp1Similar to F-box only protein 6 (F-box/G-domain protein 2) (Predicted). (291 aa)
Fbxl3F-box and leucine-rich repeat protein 3, isoform CRA_a. (428 aa)
Skp1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (165 aa)
Fbxl21F-box and leucine-rich repeat protein 21. (434 aa)
Cul2Cullin 2; Belongs to the cullin family. (745 aa)
Skp2S-phase kinase-associated protein 2 (P45). (423 aa)
Fbxl18F-box and leucine-rich repeat protein 18. (656 aa)
Cul1Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. (776 aa)
Cul5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (855 aa)
Fbxo9F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTOR [...] (435 aa)
Kif14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1672 aa)
Fbxo6F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] (284 aa)
Fbxo2F-box only protein 2. (296 aa)
Fbxo39F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (443 aa)
Fbxl8Similar to F-box and leucine-rich repeat protein 8 (Predicted). (374 aa)
Fbxo4F-box only protein 4 (Predicted). (431 aa)
BtrcBeta-transducin repeat-containing E3 ubiquitin protein ligase. (587 aa)
Wwtr1Transcriptional co-activator with PDZ-binding motif (TA)Z, isoform CRA_b. (395 aa)
Fbxl22Similar to F-box protein FBL2 (Predicted). (236 aa)
Fbxo38F-box protein 38. (1189 aa)
Fbxl15F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Required for bone mass maintenance; Belongs to the FBXL15 family. (300 aa)
Cul4aRGD1563853 protein; Belongs to the cullin family. (759 aa)
Fbxo17F-box only protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high- mannose glycoproteins (By similarity). (250 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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