STRINGSTRING
Itgb2 Itgb2 Vtn Vtn L1cam L1cam Npnt Npnt Itga1 Itga1 Itgb6 Itgb6 Itgb4 Itgb4 Itgad Itgad Adam17 Adam17 Itga2 Itga2 Itga5 Itga5 Itgav Itgav Itgb8 Itgb8 Itgb3 Itgb3 Itgae Itgae Col16a1 Col16a1 Fbn1 Fbn1 Itga2b Itga2b Itgax Itgax Adam9 Adam9 RGD1564074 RGD1564074 Mmrn1 Mmrn1 Itga3 Itga3 Ext1 Ext1 Itga7 Itga7 Itga10 Itga10 Icam1 Icam1 Itgal Itgal Itga8 Itga8 Itgb7 Itgb7 Itga9 Itga9 Itgb1 Itgb1 Ccn3 Ccn3 Plpp3 Plpp3 Emilin1 Emilin1 Itga11 Itga11 Itga4 Itga4 Itgbl1 Itgbl1 Itga6 Itga6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Itgb2Integrin beta. (768 aa)
VtnVitronectin. (490 aa)
L1camNeural cell adhesion molecule L1; Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. (1333 aa)
NpntNephronectin. (613 aa)
Itga1Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). (1180 aa)
Itgb6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (787 aa)
Itgb4Integrin beta-4; Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. (1807 aa)
ItgadIntegrin alpha-D; Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood (By similarity). (1161 aa)
Adam17Disintegrin and metalloproteinase domain-containing protein 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membra [...] (827 aa)
Itga2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1178 aa)
Itga5Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. (1099 aa)
ItgavIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa)
Itgb8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
Itgb3Integrin beta-3; Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha- V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A- G-D-V in fibrinogen gamma chain. Following ac [...] (788 aa)
ItgaeIntegrin subunit alpha E; Belongs to the integrin alpha chain family. (1169 aa)
Col16a1Collagen type XVI alpha 1 chain. (1618 aa)
Fbn1Fibrillin 1, isoform CRA_a. (2872 aa)
Itga2bIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1034 aa)
ItgaxIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1182 aa)
Adam9ADAM metallopeptidase domain 9. (845 aa)
RGD1564074Uncharacterized protein. (653 aa)
Mmrn1Multimerin 1. (1210 aa)
Itga3Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. (1067 aa)
Ext1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
Itga7Integrin alpha-7 70 kDa form; Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells (By similarity). Acts as Schwann cell receptor [...] (1160 aa)
Itga10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
Icam1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (545 aa)
ItgalIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1161 aa)
Itga8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
Itgb7Integrin beta; Belongs to the integrin beta chain family. (807 aa)
Itga9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1036 aa)
Itgb1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (798 aa)
Ccn3CCN family member 3; Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5 [...] (351 aa)
Plpp3Phospholipid phosphatase 3; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z- octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of the [...] (312 aa)
Emilin1Elastin microfibril interfacer 1 (Predicted), isoform CRA_b. (900 aa)
Itga11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1088 aa)
Itga4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1036 aa)
Itgbl1Integrin beta-like protein 1. (494 aa)
Itga6Integrin, alpha 6, isoform CRA_a; Belongs to the integrin alpha chain family. (1073 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.