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G3bp2 G3bp2 RGD1359108 RGD1359108 Eif2s1 Eif2s1 Pum2 Pum2 Ddx3x Ddx3x Atxn2 Atxn2 Ythdf2 Ythdf2 G3bp1 G3bp1 Cirbp Cirbp Rps23 Rps23 Tia1 Tia1 Ubap2l Ubap2l Ogfod1 Ogfod1 Lsm14a Lsm14a Ythdf1 Ythdf1 Bicd1 Bicd1 Ythdf3 Ythdf3 Dync1h1 Dync1h1 Csde1 Csde1 Atxn2l Atxn2l Ddx6 Ddx6 Grb7 Grb7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3bp2Similar to RNA-binding protein isoform G3BP-2a, isoform CRA_b. (449 aa)
RGD1359108Guanine nucleotide exchange C9orf72 homolog; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity. Po [...] (480 aa)
Eif2s1Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed [...] (315 aa)
Pum2Pumilio RNA-binding family member 2. (1061 aa)
Ddx3xDEAD-box helicase 3, X-linked; Belongs to the DEAD box helicase family. (662 aa)
Atxn2Ataxin 2. (1085 aa)
Ythdf2YTH N(6)-methyladenosine RNA-binding protein 2. (585 aa)
G3bp1G3BP stress granule assembly factor 1. (465 aa)
CirbpCold-inducible RNA-binding protein; Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'- UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed (By similarity). (172 aa)
Rps2340S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
Tia1TIA1 cytotoxic granule-associated RNA-binding protein. (375 aa)
Ubap2lUbiquitin-associated protein 2-like. (1105 aa)
Ogfod12-oxoglutarate and iron-dependent oxygenase domain-containing 1. (545 aa)
Lsm14aLSM14A mRNA-processing body assembly factor. (468 aa)
Ythdf1YTH N(6)-methyladenosine RNA-binding protein 1. (559 aa)
Bicd1Bicaudal D homolog 1 (Drosophila) (Predicted). (835 aa)
Ythdf3YTH N(6)-methyladenosine RNA-binding protein 3. (585 aa)
Dync1h1Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression; Belongs to the dynein heavy chain family. (4644 aa)
Csde1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (798 aa)
Atxn2lAtaxin 2-like. (1078 aa)
Ddx6DEAD-box helicase 6; Belongs to the DEAD box helicase family. (483 aa)
Grb7Growth factor receptor-bound protein 7; Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phos [...] (535 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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