STRINGSTRING
Nodal Nodal Itgb2 Itgb2 Col6a1 Col6a1 Mixl1 Mixl1 Cdc73 Cdc73 Nr0b1 Nr0b1 Grb2 Grb2 Itga4 Itga4 Lamb1 Lamb1 Lamb3 Lamb3 Leo1 Leo1 Eomes Eomes Map2k1 Map2k1 Mmp8 Mmp8 Sox2 Sox2 Mmp15 Mmp15 Inhba Inhba Hsbp1 Hsbp1 Fn1 Fn1 Mmp2 Mmp2 Ctr9 Ctr9 Mmp9 Mmp9 Paf1 Paf1 Col7a1 Col7a1 Itga7 Itga7 Sox17 Sox17 Gata6 Gata6 Hnf1b Hnf1b Rtf1 Rtf1 Col4a2 Col4a2 Col8a1 Col8a1 Hmga2 Hmga2 Col11a1 Col11a1 Nanog Nanog Mixl1-2 Mixl1-2 Pou5f1 Pou5f1 Mmp14 Mmp14 Ctnnb1 Ctnnb1 Itgav Itgav Itga5 Itga5 Col12a1 Col12a1 Vtn Vtn Setd2 Setd2 Lama3 Lama3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NodalNodal growth differentiation factor. (354 aa)
Itgb2Integrin beta. (768 aa)
Col6a1Collagen type VI alpha 1 chain. (1025 aa)
Mixl1Mix paired-like homeobox 1. (231 aa)
Cdc73Parafibromin; Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional [...] (531 aa)
Nr0b1Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. (472 aa)
Grb2Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. (217 aa)
Itga4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1036 aa)
Lamb1Laminin subunit beta 1. (1786 aa)
Lamb3Laminin, beta 3, isoform CRA_a. (1172 aa)
Leo1RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox [...] (678 aa)
EomesEomesodermin. (699 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (368 aa)
Mmp8Neutrophil collagenase; Can degrade fibrillar type I, II, and III collagens. (466 aa)
Sox2SRY-box transcription factor 2. (319 aa)
Mmp15Matrix metallopeptidase 15. (657 aa)
InhbaInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (424 aa)
Hsbp1Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). (76 aa)
Fn1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2477 aa)
Mmp272 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...] (663 aa)
Ctr9SH2 domain binding protein 1 (Tetratricopeptide repeat containing), isoform CRA_a. (1173 aa)
Mmp9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). Belongs to the peptidase M10A family. (708 aa)
Paf1RNA polymerase II-associated factor 1 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription [...] (535 aa)
Col7a1Procollagen, type VII, alpha 1 (Predicted). (2588 aa)
Itga7Integrin alpha-7 70 kDa form; Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells (By similarity). Acts as Schwann cell receptor [...] (1160 aa)
Sox17SRY-box containing gene 17 (Predicted), isoform CRA_a. (423 aa)
Gata6Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (586 aa)
Hnf1bHepatocyte nuclear factor 1-beta; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. (557 aa)
Rtf1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) (Predicted). (429 aa)
Col4a2Collagen type IV alpha 2 chain. (1645 aa)
Col8a1Collagen type VIII alpha 1 chain. (744 aa)
Hmga2Non-histone chromosomal architectural protein HMGI-C. (107 aa)
Col11a1Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. (1804 aa)
NanogNanog homeobox. (312 aa)
Mixl1-2Mix paired-like homeobox. (231 aa)
Pou5f1POU domain protein. (352 aa)
Mmp14Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which in [...] (582 aa)
Ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] (781 aa)
ItgavIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa)
Itga5Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. (1099 aa)
Col12a1Collagen alpha-1(XII) chain; Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. (3143 aa)
VtnVitronectin. (490 aa)
Setd2SET domain-containing 2, histone lysine methyltransferase. (2523 aa)
Lama3Uncharacterized protein. (2108 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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