STRINGSTRING
Sec62 Sec62 Tram1 Tram1 Zfand2a Zfand2a Sec61a2 Sec61a2 Srp68 Srp68 Srp19 Srp19 Srp72 Srp72 Srp9 Srp9 Sec61g Sec61g Sec61b Sec61b Sgta Sgta Herpud1 Herpud1 Zfand2b Zfand2b Hspa5 Hspa5 Spcs2 Spcs2 Spcs1 Spcs1 Sec61a1 Sec61a1 Srp14 Srp14 Srp54a Srp54a Ssr3 Ssr3 Srpra Srpra Tram2 Tram2 Sgtb Sgtb Glp1r Glp1r Get4 Get4 Get1 Get1 Macf1 Macf1 Ubl4a Ubl4a A0A0G2K7E7_RAT A0A0G2K7E7_RAT Q6TXH4_RAT Q6TXH4_RAT Edem1 Edem1 Man1a1 Man1a1 Sec63 Sec63 Chmp4b Chmp4b Arxes2-2 Arxes2-2 ENSRNOP00000066017 ENSRNOP00000066017 Arxes2 Arxes2 Q7TQ10_RAT Q7TQ10_RAT Spcs3 Spcs3 Get3 Get3 Bag6 Bag6 LOC499136 LOC499136
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sec62SEC62 homolog, preprotein translocation factor. (605 aa)
Tram1Translocating chain-associated membrane protein 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane; Belongs to the TRAM family. (500 aa)
Zfand2aAN1-type zinc finger protein 2A. (171 aa)
Sec61a2Sec61 translocon alpha 2 subunit. (476 aa)
Srp68Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP68 family. (625 aa)
Srp19Signal recognition particle 19 (Predicted), isoform CRA_a. (144 aa)
Srp72Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP72 family. (670 aa)
Srp9Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. (86 aa)
Sec61gSec61 translocon gamma subunit. (68 aa)
Sec61bProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
SgtaSmall glutamine-rich tetratricopeptide repeat-containing protein alpha; Co-chaperone that binds misfolded and hydrophobic patches- containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in [...] (314 aa)
Herpud1Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1. (391 aa)
Zfand2bAN1-type zinc finger protein 2B; Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism tha [...] (257 aa)
Hspa5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (654 aa)
Spcs2Signal peptidase complex subunit 2. (226 aa)
Spcs1Signal peptidase complex subunit 1. (162 aa)
Sec61a1Protein transport protein Sec61 subunit alpha isoform 1; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post- translational transport of small presecretory proteins. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC [...] (476 aa)
Srp14Signal recognition particle 14. (110 aa)
Srp54aSignal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein); Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
Ssr3Translocon-associated protein subunit gamma; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. (66 aa)
SrpraSignal recognition particle receptor ('docking protein'). (636 aa)
Tram2Translocating chain-associated membrane protein; Belongs to the TRAM family. (370 aa)
SgtbSmall glutamine-rich tetratricopeptide repeat-containing protein beta; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. (304 aa)
Glp1rGlucagon-like peptide 1 receptor; G-protein coupled receptor for glucagon-like peptide 1 (GLP- 1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1 (By similarity). (463 aa)
Get4Guided entry of tail-anchored proteins factor 4. (330 aa)
Get1Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane. (174 aa)
Macf1Microtubule-actin cross-linking factor 1; F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesion [...] (7384 aa)
Ubl4aUbiquitin-like protein 4A; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthe [...] (157 aa)
A0A0G2K7E7_RATUncharacterized protein. (68 aa)
Q6TXH4_RATLRRGT00025. (68 aa)
Edem1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (650 aa)
Man1a1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (746 aa)
Sec63SEC63 homolog, protein translocation regulator. (760 aa)
Chmp4bUncharacterized protein. (222 aa)
Arxes2-2Similar to Microsomal signal peptidase 23 kDa subunit (SPase 22 kDa subunit) (SPC22/23). (180 aa)
ENSRNOP00000066017annotation not available (135 aa)
Arxes2Signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (180 aa)
Q7TQ10_RATAa1027. (135 aa)
Spcs3Signal peptidase complex subunit 3. (180 aa)
Get3ATPase Get3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] (348 aa)
Bag6Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] (1146 aa)
LOC499136LRRGT00021. (233 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.