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Zdhhc1 Zdhhc1 Atg12 Atg12 Traf3ip2 Traf3ip2 Rnf216 Rnf216 Tomm70 Tomm70 Sec14l1 Sec14l1 Il23a Il23a Il15 Il15 Tspan6 Tspan6 Il12b Il12b Il1b Il1b Trim44 Trim44 Eif2ak4 Eif2ak4 Gpatch3 Gpatch3 LOC103692716 LOC103692716 Ifng Ifng Il4 Il4 Rnf26 Rnf26 Il23r Il23r Pqbp1 Pqbp1 Mmp12 Mmp12 Zc3h12a Zc3h12a Zmpste24 Zmpste24 Fgl2 Fgl2 Zc3hav1 Zc3hav1 Selenok Selenok Mul1 Mul1 Trim6 Trim6 Dhx58 Dhx58 Il27 Il27 Il12rb1 Il12rb1 Ptpn22 Ptpn22 Pycard Pycard Htra1 Htra1 Tkfc Tkfc C1qbp C1qbp Aim2 Aim2 Mavs Mavs Parp9 Parp9 Riok3 Riok3 Dtx3l Dtx3l Elmod2 Elmod2 Ifnlr1 Ifnlr1 Treml4 Treml4 Tspan32 Tspan32 Nploc4 Nploc4 Spn Spn LOC294154 LOC294154 Ddx58 Ddx58 Zdhhc11 Zdhhc11 Cd37 Cd37 Tarbp2 Tarbp2 Dhx9 Dhx9 Sting1 Sting1 Ufd1 Ufd1 Ifit1bl Ifit1bl Ercc6 Ercc6 Cgas Cgas Traf3ip1 Traf3ip1 Stat1 Stat1 Rnf125 Rnf125 Nlrx1 Nlrx1 Sin3a Sin3a Foxp3 Foxp3 Ppm1b Ppm1b Micb Micb Traf3 Traf3 Itch Itch Atg5 Atg5 Hsp90aa1 Hsp90aa1 Pcbp2 Pcbp2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Zdhhc1Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (488 aa)
Atg12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct [...] (141 aa)
Traf3ip2Chromosome 6 open reading frame 4, isoform CRA_a. (558 aa)
Rnf216Similar to E3 ubiquitin ligase TRIAD3B (Predicted). (910 aa)
Tomm70Mitochondrial import receptor subunit TOM70; Receptor that accelerates the import of all mitochondrial precursor proteins. (560 aa)
Sec14l1Similar to SEC14-like 1 (Predicted). (720 aa)
Il23aInterleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (196 aa)
Il15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity). (162 aa)
Tspan6Tetraspanin. (245 aa)
Il12bInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (335 aa)
Il1bInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
Trim44Tripartite motif-containing protein 44; May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 (By similarity). Is a negative regulator of PAX6 expression (By similarity). (336 aa)
Eif2ak4eIF-2-alpha kinase GCN2; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2- alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability. Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a transla [...] (1649 aa)
Gpatch3G patch domain-containing 3. (522 aa)
LOC103692716Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (733 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (156 aa)
Il4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (147 aa)
Rnf26Ring finger protein 26. (424 aa)
Il23rInterleukin 23 receptor. (624 aa)
Pqbp1Polyglutamine-binding protein 1; Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-in [...] (263 aa)
Mmp12Macrophage metalloelastase; May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity). Belongs to the peptidase M10A family. (477 aa)
Zc3h12aEndoribonuclease ZC3H12A; Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine- induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of mu [...] (596 aa)
Zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
Fgl2Fibrinogen-like 2. (429 aa)
Zc3hav1Zinc finger CCCH-type antiviral protein 1; Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the [...] (981 aa)
SelenokSelenoprotein K; Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection o [...] (93 aa)
Mul1Similar to RIKEN cDNA 0610009K11 (Predicted), isoform CRA_b. (352 aa)
Trim6Tripartite motif-containing 6. (488 aa)
Dhx58DEXH-box helicase 58. (678 aa)
Il27Interleukin 27. (234 aa)
Il12rb1Interleukin 12 receptor subunit beta 1. (738 aa)
Ptpn22Protein tyrosine phosphatase, non-receptor type 22 (Lymphoid) (Predicted). (804 aa)
PycardPYD and CARD domain-containing. (193 aa)
Htra1Serine protease HTRA1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF- binding proteins. Inhibits sign [...] (480 aa)
TkfcATP-dependent dihydroxyacetone kinase; Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (By similarity). Belongs to the dihydroxyacetone kinase (DAK) family. (578 aa)
C1qbpComplement component 1 Q subcomponent-binding protein, mitochondrial; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a [...] (279 aa)
Aim2Absent in melanoma 2. (356 aa)
MavsMitochondrial antiviral-signaling protein; Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that [...] (507 aa)
Parp9Poly [ADP-ribose] polymerase. (830 aa)
Riok3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
Dtx3lDeltex E3 ubiquitin ligase 3L. (750 aa)
Elmod2ELMO domain-containing 2. (293 aa)
Ifnlr1Interferon, lambda receptor 1. (530 aa)
Treml4Ig-like domain-containing protein. (247 aa)
Tspan32RCG48629, isoform CRA_b; Belongs to the tetraspanin (TM4SF) family. (252 aa)
Nploc4Nuclear protein localization protein 4 homolog; The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation [...] (608 aa)
SpnCD43 cytoplasmic tail; Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T- cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by [...] (392 aa)
LOC294154Similar to chromosome 6 open reading frame 106 isoform a. (216 aa)
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Predicted). (598 aa)
Zdhhc11Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (337 aa)
Cd37Leukocyte antigen CD37. (304 aa)
Tarbp2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (365 aa)
Dhx9DEAH (Asp-Glu-Ala-His) box polypeptide 9 (Predicted). (1174 aa)
Sting1Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (By similarity). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di- GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol [...] (379 aa)
Ufd1Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1- VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-deriv [...] (307 aa)
Ifit1blInterferon-induced protein with tetratricopeptide repeats 1B-like. (473 aa)
Ercc6ERCC excision repair 6, chromatin-remodeling factor. (1474 aa)
CgasCyclic GMP-AMP synthase. (510 aa)
Traf3ip1TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity). (687 aa)
Stat1Signal transducer and activator of transcription. (1083 aa)
Rnf125Ring finger protein 125. (233 aa)
Nlrx1NLR family member X1; Participates in antiviral signaling; Belongs to the NLRP family. (971 aa)
Sin3aSIN3 transcription regulator family member A. (1274 aa)
Foxp3Forkhead box P3 isoform 2. (488 aa)
Ppm1bProtein phosphatase 1B; Enzyme with a broad specificity. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF- alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). (465 aa)
MicbMHC class I polypeptide-related sequence B. (372 aa)
Traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (610 aa)
ItchE3 ubiquitin-protein ligase. (882 aa)
Atg5Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (245 aa)
Hsp90aa1Heat shock protein 90 alpha family class A member 1. (733 aa)
Pcbp2Poly(rC)-binding protein 2. (365 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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