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| | Tubb5 | Tubulin beta-5 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (444 aa) |
| | Stag1 | Stromal antigen 1. (1258 aa) |
| | Golga2 | Golgin subfamily A member 2; Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Go [...] (1026 aa) |
| | Khdc3 | KH domain-containing protein 3; Required for maintenance of euploidy during cleavage-stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA- independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (By similarity); Belongs to the KHDC1 family. (434 aa) |
| | Chek2 | CHK2 checkpoint homolog (S. pombe), isoform CRA_a. (545 aa) |
| | Kifc2 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (791 aa) |
| | Rcc1 | Regulator of chromosome condensation 1. (421 aa) |
| | Washc1 | WASH complex subunit 1; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and via WASHC2 is required for its membrane targeting. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of re [...] (442 aa) |
| | Haus6 | HAUS augmin-like complex, subunit 6. (929 aa) |
| | Kif4a | Kinesin family member 4A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1231 aa) |
| | Stag2 | Stromal antigen 2. (1268 aa) |
| | Kif11 | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1056 aa) |
| | Aurkb | Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (343 aa) |
| | Mlh1 | DNA mismatch repair protein Mlh1; Heterodimerizes with Pms2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of Pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing t [...] (765 aa) |
| | Ncor1 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity). Mediates the NR1D1-dependent repression and circadian regulation of TSHB [...] (2414 aa) |
| | Ndc80 | NDC80 kinetochore complex component. (642 aa) |
| | Haus8 | HAUS augmin-like complex subunit 8; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. (385 aa) |
| | Hdac3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activi [...] (428 aa) |
| | Incenp | Inner centromere protein. (899 aa) |
| | Clasp2 | CLIP-associating protein 2; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at le [...] (1505 aa) |
| | Haus7 | Similar to UCH37-interacting protein 1 (Predicted), isoform CRA_b. (368 aa) |
| | Flna | Filamin, alpha (Predicted), isoform CRA_a. (2639 aa) |
| | Cep63 | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double- strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). (700 aa) |
| | Tubgcp3 | Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (902 aa) |
| | Clasp1 | Cytoplasmic linker-associated protein 1. (1551 aa) |
| | Racgap1 | Rac GTPase-activating protein 1 (Predicted). (626 aa) |
| | Haus1 | HAUS augmin-like complex, subunit 1. (278 aa) |
| | Rhoa | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa) |
| | Tasor | Transcription activation suppressor. (1506 aa) |
| | Tubb1 | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa) |
| | M0R8A4_RAT | Uncharacterized protein. (247 aa) |
| | Mapre2 | Microtubule-associated protein RP/EB family member 2; May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity); Belongs to the MAPRE family. (329 aa) |
| | LOC102547011 | Uncharacterized LOC102547011. (163 aa) |
| | Arhgef10 | Rho guanine nucleotide exchange factor 10. (1133 aa) |
| | Kifc1 | Kinesin-like protein KIFC1; Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. Regulates cilium formation and structure. (693 aa) |
| | Spice1 | Spindle and centriole-associated protein 1; Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. (868 aa) |
| | Togaram1 | TOG array regulator of axonemal microtubules 1. (1826 aa) |
| | Tubgcp5 | Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (1024 aa) |
| | Numa1 | Nuclear mitotic apparatus protein 1. (2091 aa) |
| | Aurka | Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity). Required for ini [...] (397 aa) |
| | Septin1 | Septin-1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). (366 aa) |
| | Lzts2 | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa) |
| | Stard9 | StAR-related lipid transfer domain-containing 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (4558 aa) |
| | Togaram2 | TOG array regulator of axonemal microtubules 2. (998 aa) |
| | Ccdc155 | Coiled-coil domain-containing 155. (613 aa) |
| | Zfp207 | RCG33491, isoform CRA_b. (464 aa) |
| | Abraxas1 | BRCA1-A complex subunit Abraxas 1; Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX; [...] (405 aa) |
| | Smc1a | Structural maintenance of chromosomes protein 1A; Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interacti [...] (1232 aa) |
| | Cltc | Clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network (By similarity). Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge. The TACC3/ch- TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (By similarity). Plays a role in early autophagosome formation (B [...] (1675 aa) |
| | Nek2 | NIMA (never in mitosis gene a)-related kinase 2-like 1. (443 aa) |
| | Tubgcp6 | Tubulin, gamma complex-associated protein 6. (1763 aa) |
| | Mybl2 | Myeloblastosis oncogene-like 2 (Predicted). (704 aa) |
| | Tpx2 | TPX2, microtubule-associated protein homolog (Xenopus laevis) (Predicted), isoform CRA_a. (744 aa) |
| | Mapre3 | Microtubule-associated protein RP/EB family member 3; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non- centrosomal minus-end microtubules to the Golgi, an important step for polarized [...] (281 aa) |
| | Kpnb1 | Importin subunit beta-1; Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic [...] (876 aa) |
| | Poldip2 | DNA-directed polymerase delta interacting protein 2. (368 aa) |
| | Washc5 | WASH complex subunit 5. (1159 aa) |
| | LOC691918 | Similar to Centrosomal protein of 27 kDa (Cep27 protein). (129 aa) |
| | Kif3b | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (747 aa) |
| | Misp | Hypothetical LOC500797, isoform CRA_a. (651 aa) |
| | Dicer1 | Dicer 1 ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1918 aa) |
| | Csnk1d | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] (428 aa) |
| | Rab11a | Ras-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...] (216 aa) |
| | Tnks | Poly [ADP-ribose] polymerase. (1317 aa) |
| | Mapre1 | Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, a [...] (268 aa) |
| | Haus4 | Similar to chromosome 14 open reading frame 94, isoform CRA_a. (363 aa) |
| | Aspm | Abnormal spindle microtubule assembly. (3133 aa) |
| | Map9 | Microtubule-associated protein 9. (646 aa) |
| | Prc1 | Protein regulator of cytokinesis 1 (Predicted), isoform CRA_b. (606 aa) |
| | Tubgcp4 | Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (667 aa) |
| | Ccdc61 | Coiled-coil domain-containing protein 61. (512 aa) |
| | Aaas | Achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A) (Predicted), isoform CRA_a. (546 aa) |
| | Kif2a | Kinesin-like protein KIF2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily. (704 aa) |
| | Smc3 | Structural maintenance of chromosomes protein 3; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity). (1217 aa) |
| | Wrap73 | WD repeat containing, antisense to Trp73. (457 aa) |
| | Haus3 | Similar to EEA1 (Early Endosome Antigen, Rab effector) homolog family member (Eea-1). (603 aa) |
| | Aurkc | Aurora kinase C; Belongs to the protein kinase superfamily. (308 aa) |
| | LOC108348136 | HAUS augmin-like complex subunit 1; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. (278 aa) |
| | Abraxas2 | Abraxas 2, BRISC complex subunit. (424 aa) |
| | Cep192 | Centrosomal protein 192. (2376 aa) |
| | Rps3 | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8- oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). S [...] (243 aa) |
| | Bccip | BRCA2 and CDKN1A-interacting protein. (370 aa) |
| | Tubgcp2 | Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (905 aa) |
| | Sac3d1 | SAC3 domain containing 1. (427 aa) |
| | Lsm14a | LSM14A mRNA-processing body assembly factor. (468 aa) |
| | Cenpe | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2439 aa) |
| | Haus5 | HAUS augmin-like complex, subunit 5. (616 aa) |
| | Kif23 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (944 aa) |
| | Fbxo5 | F-box only protein 5 (Predicted). (418 aa) |
| | Ino80 | INO80 complex ATPase subunit. (1559 aa) |
| | Map10 | Microtubule-associated protein 10; Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis. (888 aa) |
| | Ccdc69 | Similar to DNA segment, Chr 11, ERATO Doi 461, expressed (Predicted), isoform CRA_a. (202 aa) |
| | Pibf1 | Progesterone immunomodulatory-binding factor 1. (757 aa) |
| | Cdc20 | Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...] (499 aa) |
