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Samhd1 Samhd1 Mmp12 Mmp12 Ythdf2 Ythdf2 Cnot7 Cnot7 Mettl3 Mettl3 Mul1 Mul1 Ptpn2 Ptpn2 Cactin Cactin Dcst1 Dcst1 Adar Adar Trex1 Trex1 Isg15 Isg15 Oas1a Oas1a Ttll12 Ttll12 Usp18 Usp18 Ythdf3 Ythdf3 Nlrc5 Nlrc5 Oas3 Oas3 Stat2 Stat2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Samhd1SAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase 1. (620 aa)
Mmp12Macrophage metalloelastase; May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity). Belongs to the peptidase M10A family. (477 aa)
Ythdf2YTH N(6)-methyladenosine RNA-binding protein 2. (585 aa)
Cnot7CCR4-NOT transcription complex, subunit 7. (285 aa)
Mettl3Methyltransferase-like 3, isoform CRA_b; Belongs to the MT-A70-like family. (580 aa)
Mul1Similar to RIKEN cDNA 0610009K11 (Predicted), isoform CRA_b. (352 aa)
Ptpn2Tyrosine-protein phosphatase non-receptor type 2; Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the develop [...] (363 aa)
CactinCactin, spliceosome C complex subunit. (764 aa)
Dcst1DC-STAMP domain-containing 1. (822 aa)
AdarDouble-stranded RNA-specific adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structur [...] (1175 aa)
Trex1Three prime repair exonuclease 1. (316 aa)
Isg15Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). (161 aa)
Oas1a2'-5'-oligoadenylate synthase 1A; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition [...] (367 aa)
Ttll12Tubulin tyrosine ligase-like 12. (639 aa)
Usp18Ubiquitin-specific peptidase 18; Belongs to the peptidase C19 family. (362 aa)
Ythdf3YTH N(6)-methyladenosine RNA-binding protein 3. (585 aa)
Nlrc5NLR family, CARD domain-containing 5. (1913 aa)
Oas32'-5'-oligoadenylate synthase 3; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibi [...] (1005 aa)
Stat2Signal transducer and activator of transcription. (842 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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