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Ube2l3 Ube2l3 Ube2e3 Ube2e3 Ube2g2 Ube2g2 Ube2u Ube2u Ube2k Ube2k Ube2l6 Ube2l6 Ube2d4 Ube2d4 Ube2q1 Ube2q1 Ube2e2 Ube2e2 Ube2z Ube2z D3ZL88_RAT D3ZL88_RAT Birc6 Birc6 Ube2n Ube2n Cdc34 Cdc34 Ube2j2 Ube2j2 Ube2d1 Ube2d1 Ube2ql1 Ube2ql1 Aktip Aktip Ube2a Ube2a Ube2d3 Ube2d3 LOC103694506 LOC103694506 Ube2h Ube2h M0R6B6_RAT M0R6B6_RAT Ube2q2 Ube2q2 Ube2b Ube2b Ube2r2 Ube2r2 Ube2o Ube2o Ube2g1 Ube2g1 Ube2e1 Ube2e1 Ube2t Ube2t Ube2s Ube2s Ube2c Ube2c Ube2j1 Ube2j1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ube2l3Ubiquitin-conjugating enzyme E2L 3 (Predicted). (166 aa)
Ube2e3Ubiquitin-conjugating enzyme E2E 3; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
Ube2g2Ubiquitin-conjugating enzyme E2G 2 (Predicted), isoform CRA_b; Belongs to the ubiquitin-conjugating enzyme family. (165 aa)
Ube2uUbiquitin-conjugating enzyme E2 U. (337 aa)
Ube2kHuntingtin interacting protein 2 (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
Ube2l6Ubiquitin/ISG15-conjugating enzyme E2 L6; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. (153 aa)
Ube2d4Ubiquitin-conjugating enzyme E2 D2B; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection Plays a role i [...] (147 aa)
Ube2q1Ubiquitin-conjugating enzyme E2Q (Putative) (Predicted), isoform CRA_a. (422 aa)
Ube2e2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (126 aa)
Ube2zUbiquitin-conjugating enzyme E2 Z; Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation; Belongs to the ubiquitin-conjugating enzyme family. (356 aa)
D3ZL88_RATUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (150 aa)
Birc6Baculoviral IAP repeat-containing 6. (3993 aa)
Ube2nUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
Cdc34RCG29282, isoform CRA_b; Belongs to the ubiquitin-conjugating enzyme family. (235 aa)
Ube2j2Similar to Ubc6p homolog, isoform CRA_a. (271 aa)
Ube2d1Ubiquitin-conjugating enzyme E2 D1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Mediates the selective degradation of short- lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4 (By [...] (147 aa)
Ube2ql1Ubiquitin-conjugating enzyme E2Q family-like 1. (304 aa)
AktipAKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity). (292 aa)
Ube2aUbiquitin-conjugating enzyme E2A, RAD6 homolog (S. cerevisiae); Belongs to the ubiquitin-conjugating enzyme family. (162 aa)
Ube2d3Ubiquitin-conjugating enzyme E2 D3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed [...] (147 aa)
LOC103694506Ubiquitin-conjugating enzyme E2 W; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation [...] (146 aa)
Ube2hUbiquitin-conjugating enzyme E2H; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
M0R6B6_RATUBIQUITIN_CONJUGAT_2 domain-containing protein. (150 aa)
Ube2q2Ubiquitin-conjugating enzyme E2Q family member 2. (376 aa)
Ube2bUbiquitin-conjugating enzyme E2 B; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys- 120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-l [...] (180 aa)
Ube2r2Ubiquitin-conjugating enzyme E2R 2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
Ube2oUbiquitin-conjugating enzyme E2O. (1138 aa)
Ube2g1Ubiquitin-conjugating enzyme E2 G1, N-terminally processed; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
Ube2e1Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (173 aa)
Ube2tUbiquitin-conjugating enzyme E2T (Putative) (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family. (204 aa)
Ube2sUbiquitin-conjugating enzyme E2 S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiqui [...] (223 aa)
Ube2cUbiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
Ube2j1Ubiquitin-conjugating enzyme E2, J1. (248 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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