11 items (Rattus norvegicus) - STRING interaction network

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Your Input:
	Sesn2	Similar to Sestrin 2 (Hi95). (480 aa)
	Hnf1a	Hepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'- GTTAATNATTAAC-3' (By similarity). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). Belongs to the HNF1 homeobox family. (628 aa)
	Rptor	Regulatory-associated protein of MTOR, complex 1. (1335 aa)
	Sesn3	Sestrin 3 (Predicted). (492 aa)
	Mtor	Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...] (2549 aa)
	Ubr1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1329 aa)
	Ubr2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
	Lars1	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1178 aa)
	Rragd	Ras-related GTP binding D (Predicted), isoform CRA_b. (399 aa)
	Sesn1	Sestrin 1. (551 aa)
	Klhl22	Kelch-like protein 22; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stim [...] (707 aa)

Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lars1	Mtor	ENSRNOP00000025284	ENSRNOP00000014167	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...]	0.566
Lars1	Rptor	ENSRNOP00000025284	ENSRNOP00000005337	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Regulatory-associated protein of MTOR, complex 1.	0.522
Lars1	Rragd	ENSRNOP00000025284	ENSRNOP00000061453	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Ras-related GTP binding D (Predicted), isoform CRA_b.	0.771
Lars1	Sesn1	ENSRNOP00000025284	ENSRNOP00000073119	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Sestrin 1.	0.400
Lars1	Sesn2	ENSRNOP00000025284	ENSRNOP00000062295	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Similar to Sestrin 2 (Hi95).	0.646
Mtor	Lars1	ENSRNOP00000014167	ENSRNOP00000025284	Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...]	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.566
Mtor	Rptor	ENSRNOP00000014167	ENSRNOP00000005337	Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...]	Regulatory-associated protein of MTOR, complex 1.	0.999
Mtor	Rragd	ENSRNOP00000014167	ENSRNOP00000061453	Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...]	Ras-related GTP binding D (Predicted), isoform CRA_b.	0.988
Mtor	Sesn1	ENSRNOP00000014167	ENSRNOP00000073119	Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...]	Sestrin 1.	0.731
Mtor	Sesn2	ENSRNOP00000014167	ENSRNOP00000062295	Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...]	Similar to Sestrin 2 (Hi95).	0.900
Mtor	Sesn3	ENSRNOP00000014167	ENSRNOP00000011008	Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...]	Sestrin 3 (Predicted).	0.825
Rptor	Lars1	ENSRNOP00000005337	ENSRNOP00000025284	Regulatory-associated protein of MTOR, complex 1.	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.522
Rptor	Mtor	ENSRNOP00000005337	ENSRNOP00000014167	Regulatory-associated protein of MTOR, complex 1.	Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...]	0.999
Rptor	Rragd	ENSRNOP00000005337	ENSRNOP00000061453	Regulatory-associated protein of MTOR, complex 1.	Ras-related GTP binding D (Predicted), isoform CRA_b.	0.992
Rptor	Sesn1	ENSRNOP00000005337	ENSRNOP00000073119	Regulatory-associated protein of MTOR, complex 1.	Sestrin 1.	0.585
Rptor	Sesn2	ENSRNOP00000005337	ENSRNOP00000062295	Regulatory-associated protein of MTOR, complex 1.	Similar to Sestrin 2 (Hi95).	0.831
Rptor	Sesn3	ENSRNOP00000005337	ENSRNOP00000011008	Regulatory-associated protein of MTOR, complex 1.	Sestrin 3 (Predicted).	0.780
Rragd	Lars1	ENSRNOP00000061453	ENSRNOP00000025284	Ras-related GTP binding D (Predicted), isoform CRA_b.	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.771
Rragd	Mtor	ENSRNOP00000061453	ENSRNOP00000014167	Ras-related GTP binding D (Predicted), isoform CRA_b.	Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...]	0.988
Rragd	Rptor	ENSRNOP00000061453	ENSRNOP00000005337	Ras-related GTP binding D (Predicted), isoform CRA_b.	Regulatory-associated protein of MTOR, complex 1.	0.992

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