STRINGSTRING
Mrnip Mrnip Rif1 Rif1 Setd2 Setd2 Wdr48 Wdr48 Kat5 Kat5 Ruvbl1 Ruvbl1 Khdc3 Khdc3 Ddx11 Ddx11 Rad51ap1 Rad51ap1 Fancb Fancb Shld2 Shld2 Actb Actb Ube2n Ube2n A0A0G2JZ27_RAT A0A0G2JZ27_RAT Pogz Pogz Timeless Timeless Ogg1 Ogg1 LOC103691995 LOC103691995 Pot1 Pot1 Chek1 Chek1 Cgas Cgas Slf2 Slf2 Blm Blm Pnkp Pnkp Trip12 Trip12 Ep400 Ep400 Ercc6 Ercc6 Klhl15 Klhl15 Kdm4d Kdm4d RGD1566138 RGD1566138 Was Was Ooep Ooep Mbtd1 Mbtd1 Mrgbp Mrgbp Mms19 Mms19 Hdgfl2 Hdgfl2 Meaf6 Meaf6 Spire1 Spire1 F1LT90_RAT F1LT90_RAT Ube2v2 Ube2v2 Polq Polq Hmga2 Hmga2 Kdm4e Kdm4e Radx Radx Twist1 Twist1 Zfp365 Zfp365 Spidr Spidr Rad51 Rad51 Kdm1a Kdm1a Terf2ip Terf2ip Wrap53 Wrap53 Foxm1 Foxm1 Otub2 Otub2 Ubr5 Ubr5 Setmar Setmar Sirt6 Sirt6 Morf4l2 Morf4l2 Parp1 Parp1 Nudt16l1 Nudt16l1 Fh Fh Ppp4r3b Ppp4r3b Fignl1 Fignl1 Parpbp Parpbp Actr2 Actr2 Arid2 Arid2 Recql5 Recql5 Ing3 Ing3 Yeats4 Yeats4 Helq Helq Mad2l2 Mad2l2 Rtel1 Rtel1 Sirt7 Sirt7 Brd8 Brd8 Hsf1 Hsf1 Pml Pml Epc2 Epc2 Prkdc Prkdc Rnf169 Rnf169 Dtx3l Dtx3l Cyren Cyren Parp9 Parp9 Brd8dc Brd8dc Fus Fus Usp51 Usp51 Tex15 Tex15 Aunip Aunip Ppp4r2 Ppp4r2 Helb Helb Shld1 Shld1 Otub1 Otub1 Vps72 Vps72 Ruvbl2 Ruvbl2 Pias4 Pias4 Ubqln4 Ubqln4 Ppp4c Ppp4c Dmap1 Dmap1 Fbh1 Fbh1 Kmt5c Kmt5c Spire2 Spire2 Kmt5b Kmt5b Nsd2 Nsd2 Dek Dek Mgmt Mgmt Epc1 Epc1 Smchd1 Smchd1 Tp53bp1 Tp53bp1 Rpa2 Rpa2 Rbbp8 Rbbp8 Parp3 Parp3 Actl6a Actl6a Morf4l1 Morf4l1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MrnipSimilar to RIKEN cDNA 3010026O09 (Predicted), isoform CRA_b. (343 aa)
Rif1Replication timing regulatory factor 1. (2416 aa)
Setd2SET domain-containing 2, histone lysine methyltransferase. (2523 aa)
Wdr48WD repeat domain 48. (691 aa)
Kat5Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] (487 aa)
Ruvbl1RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with oth [...] (456 aa)
Khdc3KH domain-containing protein 3; Required for maintenance of euploidy during cleavage-stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA- independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (By similarity); Belongs to the KHDC1 family. (434 aa)
Ddx11DEAD/H-box helicase 11. (696 aa)
Rad51ap1RAD51-associated protein 1. (337 aa)
FancbFA complementation group B. (853 aa)
Shld2Shieldin complex subunit 2. (911 aa)
ActbActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
Ube2nUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
A0A0G2JZ27_RATFH2 domain-containing protein. (1201 aa)
PogzPogo transposable element-derived with ZNF domain. (1410 aa)
TimelessProtein timeless homolog; Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (By similarity). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (B [...] (1205 aa)
Ogg1DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. (345 aa)
LOC103691995MRG/MORF4L binding protein. (204 aa)
Pot1Similar to POT1-like telomere end-binding protein. (638 aa)
Chek1Serine/threonine-protein kinase Chk1. (773 aa)
CgasCyclic GMP-AMP synthase. (510 aa)
Slf2SMC5-SMC6 complex localization factor 2. (1163 aa)
BlmBLM RecQ-like helicase. (1401 aa)
PnkpPolynucleotide kinase 3'-phosphatase. (548 aa)
Trip12E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spr [...] (2038 aa)
Ep400E1A-binding protein p400. (3152 aa)
Ercc6ERCC excision repair 6, chromatin-remodeling factor. (1474 aa)
Klhl15Kelch-like protein 15; Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits and regulating PP2A holoenzyme composition. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, [...] (604 aa)
Kdm4dLysine demethylase 4D. (510 aa)
RGD1566138Similar to Zinc finger, CW type with PWWP domain 1. (625 aa)
WasWASP actin nucleation-promoting factor. (503 aa)
OoepOocyte-expressed protein. (157 aa)
Mbtd1Mbt domain-containing 1. (717 aa)
MrgbpMRG domain-binding protein. (204 aa)
Mms19MMS19 homolog, cytosolic iron-sulfur assembly component. (1031 aa)
Hdgfl2Hepatoma-derived growth factor-related protein 2; Involved in cellular growth control, through the regulation of cyclin D1 expression; Belongs to the HDGF family. (669 aa)
Meaf6MYST/Esa1-associated factor 6. (191 aa)
Spire1Spire homolog 1 (Drosophila) (Predicted), isoform CRA_b. (749 aa)
F1LT90_RATUncharacterized protein. (471 aa)
Ube2v2Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage; Belongs to the ubiquitin-conjugating enzym [...] (145 aa)
PolqPolymerase (DNA directed), theta (Predicted), isoform CRA_a. (2547 aa)
Hmga2Non-histone chromosomal architectural protein HMGI-C. (107 aa)
Kdm4eLysine-specific demethylase 4D; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys- 20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate (By similarity). (510 aa)
RadxRPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks. (844 aa)
Twist1Twist family bHLH transcription factor 1. (203 aa)
Zfp365Protein ZNF365; Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth. Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) b [...] (408 aa)
SpidrScaffold protein involved in DNA repair. (878 aa)
Rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
Kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (867 aa)
Terf2ipTelomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology- directed repair ( [...] (393 aa)
Wrap53Telomerase Cajal body protein 1; RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically b [...] (532 aa)
Foxm1Forkhead box protein M1; Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response (By similarity). (771 aa)
Otub2OTU domain, ubiquitin aldehyde binding 2 (Predicted), isoform CRA_a. (234 aa)
Ubr5E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) for the DNA damage response. P [...] (2430 aa)
SetmarHistone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. (315 aa)
Sirt6Sirtuin 6 (Silent mating type information regulation 2, homolog) 6 (S. cerevisiae), isoform CRA_a. (330 aa)
Morf4l2Mortality factor 4-like protein 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] (288 aa)
Parp1Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Mediates the poly(ADP-ribosyl)ation of a number of proteins, including itself, APLF an [...] (1014 aa)
Nudt16l1Similar to 1110001K21Rik protein, isoform CRA_a. (211 aa)
FhFumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting [...] (507 aa)
Ppp4r3bProtein phosphatase 4, regulatory subunit 3B. (820 aa)
Fignl1Fidgetin-like protein 1; Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (By similarity). May play a role in the control of male meiosis dynamic (By similarity). (677 aa)
ParpbpPCNA-interacting partner; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity). Binds single- strand DNA and poly(A) homopolymers; Belongs to the PARI family. (572 aa)
Actr2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promote [...] (394 aa)
Arid2AT-rich interaction domain 2. (1826 aa)
Recql5ATP-dependent DNA helicase Q5; DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination (By similarity). Belongs to the helica [...] (973 aa)
Ing3Inhibitor of growth protein 3; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicat [...] (421 aa)
Yeats4YEATS domain containing 4 (Predicted), isoform CRA_b. (227 aa)
HelqRCG37823, isoform CRA_c. (1065 aa)
Mad2l2Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] (234 aa)
Rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1274 aa)
Sirt7NAD-dependent protein deacetylase sirtuin-7; NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase and deglutarylase), depending on the context. Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts a [...] (402 aa)
Brd8Bromodomain-containing 8. (957 aa)
Hsf1Heat shock transcription factor 1. (525 aa)
PmlPromyelocytic leukemia. (886 aa)
Epc2Enhancer of polycomb homolog. (808 aa)
PrkdcProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4126 aa)
Rnf169Ring finger protein 169. (694 aa)
Dtx3lDeltex E3 ubiquitin ligase 3L. (750 aa)
CyrenCell cycle regulator of non-homologous end joining; Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases. Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present. Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homolog [...] (160 aa)
Parp9Poly [ADP-ribose] polymerase. (830 aa)
Brd8dcRIKEN cDNA 4933408B17 gene. (272 aa)
FusFusion, derived from t(1216) malignant liposarcoma (Human). (518 aa)
Usp51Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (696 aa)
Tex15Testis-expressed 15, meiosis and synapsis-associated. (3063 aa)
AunipAurora kinase A and ninein-interacting protein; DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during [...] (347 aa)
Ppp4r2Protein phosphatase 4, regulatory subunit 2. (413 aa)
HelbSimilar to Helicase (DNA) B (Predicted). (1087 aa)
Shld1Shieldin complex subunit 1. (209 aa)
Otub1Ubiquitin thioesterase OTUB1; Hydrolase that can specifically remove compared to 'Lys-48'- linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha [...] (271 aa)
Vps72Vacuolar protein sorting 72 homolog (S. cerevisiae). (364 aa)
Ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
Pias4Protein inhibitor of-activated STAT, 4. (507 aa)
Ubqln4Ubiquilin 4 (Predicted). (595 aa)
Ppp4cSerine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...] (307 aa)
Dmap1DNA methyltransferase 1-associated protein 1. (468 aa)
Fbh1F-box only protein 18 (Predicted). (1042 aa)
Kmt5cHistone-lysine N-methyltransferase KMT5C; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] (470 aa)
Spire2Spire-type actin nucleation factor 2. (714 aa)
Kmt5bHistone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] (883 aa)
Nsd2Nuclear receptor-binding SET domain protein 2. (1346 aa)
DekProtein DEK; Involved in chromatin organization. (378 aa)
MgmtMethylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated; Belongs to the MGMT family. (209 aa)
Epc1Enhancer of polycomb homolog 1 (Drosophila) (Predicted). (762 aa)
Smchd1Structural maintenance of chromosomes flexible hinge domain-containing 1. (2006 aa)
Tp53bp1Tumor protein p53-binding protein 1. (1972 aa)
Rpa2Replication protein A 32 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRI [...] (270 aa)
Rbbp8DNA endonuclease RBBP8; Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phas [...] (893 aa)
Parp3Poly [ADP-ribose] polymerase. (526 aa)
Actl6aActin-like 6A; Belongs to the actin family. (429 aa)
Morf4l1Mortality factor 4-like protein 1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicativ [...] (323 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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