STRINGSTRING
Nphp3 Nphp3 Armc4 Armc4 Kcnq1 Kcnq1 Cep126 Cep126 Dzip1 Dzip1 Cplane2 Cplane2 Wdr60 Wdr60 Cluap1 Cluap1 Fank1 Fank1 Ift122 Ift122 Ttbk2 Ttbk2 Traf3ip1 Traf3ip1 Ick Ick Fam92a Fam92a Ift88 Ift88 MGC94199-2 MGC94199-2 Nphp4 Nphp4 Prkacb Prkacb Nphp1 Nphp1 Magi2 Magi2 Ift52 Ift52 Clcn4 Clcn4 Disc1 Disc1 Prkaca Prkaca MGC94199 MGC94199 Enkd1 Enkd1 Kcnf1 Kcnf1 Dnali1 Dnali1 Fam183a Fam183a Cfap36 Cfap36 Tulp3 Tulp3 Kcnj10 Kcnj10 Mok Mok Pqbp1 Pqbp1 Invs Invs Ift20 Ift20 Rab8a Rab8a Nek8 Nek8 Mlf1 Mlf1 Spaca9 Spaca9 RGD1561795 RGD1561795 Prkar2b Prkar2b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Nphp3Nephrocystin 3. (1325 aa)
Armc4Armadillo repeat-containing 4. (1036 aa)
Kcnq1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic. During beta-adrenergic receptor stimulation participates in cardiac repolarization by [...] (669 aa)
Cep126Centrosomal protein 126. (1092 aa)
Dzip1DAZ-interacting zinc finger protein 1. (848 aa)
Cplane2Similar to novel protein (Predicted), isoform CRA_b. (258 aa)
Wdr60WD repeat domain 60. (1037 aa)
Cluap1Clusterin-associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. (413 aa)
Fank1Fibronectin type 3 and ankyrin repeat domains 1 protein; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis. (344 aa)
Ift122Intraflagellar transport 122. (1241 aa)
Ttbk2Tau tubulin kinase 2. (1242 aa)
Traf3ip1TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity). (687 aa)
IckSerine/threonine-protein kinase ICK; Required for ciliogenesis, particularly in neuronal and retinal progenitor cells (By similarity). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (By similarity). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a role in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activi [...] (629 aa)
Fam92aFamily with sequence similarity 92 member A. (355 aa)
Ift88Intraflagellar transport 88. (825 aa)
MGC94199-2Similar to RIKEN cDNA 2610301B20; EST AI428449. (210 aa)
Nphp4RCG31055, isoform CRA_a. (1428 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (351 aa)
Nphp1Nephronophthisis 1 (Juvenile) homolog (Human) (Predicted). (457 aa)
Magi2Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation (By similarity). Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. (1138 aa)
Ift52Intraflagellar transport 52. (369 aa)
Clcn4H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. (754 aa)
Disc1Disrupted in schizophrenia 1 homolog; Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt- mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, includ [...] (846 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (351 aa)
MGC94199Protein C8orf37 homolog; May be involved in photoreceptor outer segment disk morphogenesis (By similarity). (210 aa)
Enkd1Enkurin domain-containing 1. (346 aa)
Kcnf1Potassium voltage-gated channel modifier subfamily F member 1; Belongs to the potassium channel family. (505 aa)
Dnali1Axonemal dynein light intermediate polypeptide 1; May play a dynamic role in flagellar motility; Belongs to the inner dynein arm light chain family. (258 aa)
Fam183aFamily with sequence similarity 183 member A. (137 aa)
Cfap36Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. (343 aa)
Tulp3Tubby-like protein; Belongs to the TUB family. (451 aa)
Kcnj10ATP-sensitive inward rectifier potassium channel 10; May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellu [...] (378 aa)
MokMOK protein kinase; Belongs to the protein kinase superfamily. (419 aa)
Pqbp1Polyglutamine-binding protein 1; Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-in [...] (263 aa)
InvsInversin. (1003 aa)
Ift20Hypothetical LOC287541 (Predicted), isoform CRA_c. (157 aa)
Rab8aRas-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa)
Nek8Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway (By similarity); Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. (698 aa)
Mlf1Myeloid leukemia factor 1 (Predicted), isoform CRA_a. (282 aa)
Spaca9Sperm acrosome-associated protein 9. (168 aa)
RGD1561795Uncharacterized protein C11orf97 homolog. (149 aa)
Prkar2bcAMP-dependent protein kinase type II-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. (416 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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