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| | Itgbl1 | Integrin beta-like protein 1. (494 aa) |
| | Matn3 | Matrilin 3. (463 aa) |
| | Vwce | Von Willebrand factor C and EGF domains. (662 aa) |
| | Thbs3 | Thrombospondin 3. (955 aa) |
| | Tmeff2 | Transmembrane protein with EGF-like and two follistatin-like domains 2. (374 aa) |
| | Lamc3 | Laminin subunit gamma 3. (1582 aa) |
| | Lrp6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa) |
| | Adgrl4 | Adhesion G protein-coupled receptor L4; Endothelial orphan receptor that acts as a key regulator of angiogenesis. (738 aa) |
| | Ltbp2 | Latent-transforming growth factor beta-binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly. Belongs to the LTBP family. (1831 aa) |
| | Tnc | Tenascin C. (2019 aa) |
| | LOC100910418 | Tissue-type plasminogen activator-like. (309 aa) |
| | Efemp2 | EGF-containing fibulin extracellular matrix protein 2. (443 aa) |
| | Nrg1 | Pro-neuregulin-1, membrane-bound isoform; Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gla [...] (700 aa) |
| | Dll1 | Delta-like protein 1; Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (By similarity). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intr [...] (714 aa) |
| | Itgb4 | Integrin beta-4; Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. (1807 aa) |
| | Scarf1 | Scavenger receptor class F, member 1. (452 aa) |
| | Fat1 | FAT atypical cadherin 1. (4601 aa) |
| | Adam34l | A disintegrin and metalloprotease domain 34-like. (792 aa) |
| | Lama5 | Laminin, alpha 5, isoform CRA_a. (3713 aa) |
| | Thbs4 | Thrombospondin-4; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via it [...] (961 aa) |
| | Npnt | Nephronectin. (613 aa) |
| | Megf8 | Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling. (2789 aa) |
| | Malrd1 | MAM and LDL receptor class A domain-containing 1. (1679 aa) |
| | Cubn | Cubilin; Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal t [...] (3623 aa) |
| | Lrp2 | Low-density lipoprotein receptor-related protein 2; Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B. In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium. Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated r [...] (4660 aa) |
| | LOC100910178 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1104 aa) |
| | Egfl6 | EGF-like-domain, multiple 6. (551 aa) |
| | Lama3 | Uncharacterized protein. (2108 aa) |
| | Dner | Delta/notch-like EGF repeat-containing. (746 aa) |
| | Adam11 | ADAM metallopeptidase domain 11. (778 aa) |
| | Scube2 | Signal peptide, CUB domain and EGF-like domain-containing 2. (1000 aa) |
| | Dlk1 | Protein delta homolog 1; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. (383 aa) |
| | Thbs1 | Thrombospondin 1. (1152 aa) |
| | C1r | Complement C1r; Belongs to the peptidase S1 family. (707 aa) |
| | Svep1 | Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1; May play a role in the cell attachment process. (3681 aa) |
| | Celsr3 | Cadherin EGF LAG seven-pass G-type receptor 3; Receptor that may have an important role in cell/cell signaling during nervous system formation; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. (3313 aa) |
| | Susd1 | Sushi domain-containing 1. (634 aa) |
| | Selp | P-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. (767 aa) |
| | Tnr | Tenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repul [...] (1358 aa) |
| | Adgre1 | Adhesion G protein-coupled receptor E2; Orphan receptor involved in cell adhesion and probably in cell-cell interactions involved specifically cells of the immune system. May play a role in regulatory T-cells (Treg) development. (932 aa) |
| | Comp | Cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] (755 aa) |
| | Nrxn1 | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N- terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect [...] (922 aa) |
| | Oit3 | Oncoprotein-induced transcript 3 protein; May be involved in hepatocellular function and development. (545 aa) |
| | Lamb2 | Laminin subunit beta-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1801 aa) |
| | Pros1 | Vitamin K-dependent protein S; Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. (675 aa) |
| | Adam22 | ADAM metallopeptidase domain 22. (775 aa) |
| | Mep1b | Meprin A subunit beta; Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. (704 aa) |
| | Egfl8 | Epidermal growth factor-like protein 8. (285 aa) |
| | Tmeff1 | Tomoregulin-1; May inhibit NODAL and BMP signaling during neural patterning. (373 aa) |
| | Cfc1 | Cripto, FRL-1, cryptic family 1. (164 aa) |
| | Atraid | Similar to apoptosis related protein APR-3; p18 protein (Predicted), isoform CRA_b. (226 aa) |
| | Otog | Otogelin (Predicted). (2902 aa) |
| | Cntnap5c | Contactin-associated protein like 5-4; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication; Belongs to the neurexin family. (1279 aa) |
| | Ncan | 150 kDa adult core glycoprotein; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N- CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. (1263 aa) |
| | F12 | Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). (603 aa) |
| | Edil3 | EGF-like repeats and discoidin domains 3. (479 aa) |
| | Adam2 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). (737 aa) |
| | Cntnap4 | Contactin-associated protein 4. (1241 aa) |
| | Mfge8 | Lactadherin; Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Appears to participate in the O-acetylation of GD3 ganglioside sialic acid. (483 aa) |
| | Nrxn3 | Neurexin-3; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. (430 aa) |
| | Ntng1 | Netrin G1. (463 aa) |
| | LOC100360238 | Disintegrin and metalloproteinase domain-containing protein 1; May be involved in sperm-egg fusion. (804 aa) |
| | Pamr1 | Peptidase domain-containing-associated with muscle regeneration 1; Belongs to the peptidase S1 family. (720 aa) |
| | Fbn2 | Fibrillin 2. (2590 aa) |
| | Tll1 | Metalloendopeptidase. (1012 aa) |
| | Reln | Reelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity). (3462 aa) |
| | Stab2 | 175 kDa stabilin-2; Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity o [...] (2534 aa) |
| | Adam28 | ADAM metallopeptidase domain 28. (718 aa) |
| | Fat2 | Protocadherin Fat 2; Involved in the regulation of cell migration. May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development. (4351 aa) |
| | Adam5 | Disintegrin and metalloproteinase domain-containing protein 5; This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity). (753 aa) |
| | Tgfa | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (159 aa) |
| | Nell1 | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization (By similarity). (810 aa) |
| | Fbn1 | Fibrillin 1, isoform CRA_a. (2872 aa) |
| | Megf6 | Multiple epidermal growth factor-like domains protein 6. (1574 aa) |
| | Agrn | Agrin C-terminal 110 kDa subunit; [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. This neuron-specific (z+) isoform is a component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium [...] (1941 aa) |
| | Tdgf1 | Teratocarcinoma-derived growth factor 1. (167 aa) |
| | Vwa2 | Von Willebrand factor A domain-containing 2. (792 aa) |
| | Lrp1b | Uncharacterized protein. (752 aa) |
| | Impg2 | Interphotoreceptor matrix proteoglycan 2; Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin. (1241 aa) |
| | Fbln1 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (705 aa) |
| | Vcan | Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. (3058 aa) |
| | Ntng2 | Netrin G2 (Predicted), isoform CRA_a. (564 aa) |
| | Habp2 | Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity); Belongs to the peptidase S1 family. (558 aa) |
| | Umodl1 | Uromodulin-like 1. (1325 aa) |
| | Adam9 | ADAM metallopeptidase domain 9. (845 aa) |
| | LOC304725 | Contactin-associated protein like 5-2; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication; Belongs to the neurexin family. (1292 aa) |
| | Megf11 | Multiple EGF-like-domains 11. (1096 aa) |
| | Adam23 | ADAM metallopeptidase domain 23. (828 aa) |
| | Adam33 | ADAM metallopeptidase domain 33. (796 aa) |
| | D4AA49_RAT | Uncharacterized protein. (951 aa) |
| | Bmp1 | Metalloendopeptidase. (990 aa) |
| | Ltbp1 | Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (By similarity); Belongs to the LTBP family. (1712 aa) |
| | Adam24 | ADAM metallopeptidase domain 24. (740 aa) |
| | Cntnap5b | Contactin-associated protein like 5-3; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication; Belongs to the neurexin family. (1307 aa) |
| | Adam15 | Disintegrin and metalloproteinase domain-containing protein 15; Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. [...] (864 aa) |
| | F7 | Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity). Belongs to the peptidase S1 family. (446 aa) |
| | Notch3 | Neurogenic locus notch homolog protein 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/o [...] (2319 aa) |
| | Lamc2 | Laminin subunit gamma 2. (1192 aa) |
| | Crb1 | Crumbs homolog 1 (Drosophila) (Predicted). (1407 aa) |
| | Vldlr | Very low-density lipoprotein receptor; Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). (873 aa) |
| | Fat4 | FAT atypical cadherin 4. (4981 aa) |
| | Tek | Endothelial-specific receptor tyrosine kinase. (1120 aa) |
| | Megf10 | Multiple EGF-like domains 10. (1145 aa) |
| | Mmrn1 | Multimerin 1. (1210 aa) |
| | Crb2 | Crumbs cell polarity complex component 2. (1283 aa) |
| | Slit1 | Slit homolog 1 protein; Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb (By similarity). (1530 aa) |
| | Hspg2 | Uncharacterized protein. (2449 aa) |
| | Sele | E-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. (556 aa) |
| | Egfem1 | Uncharacterized protein. (384 aa) |
| | Lrp1 | Low-density lipoprotein receptor-related protein 1 intracellular domain; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2- macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotr [...] (4545 aa) |
| | Hmcn1 | Hemicentin 1. (5635 aa) |
| | Adam32 | ADAM metallopeptidase domain 32. (766 aa) |
| | Vwde | Von Willebrand factor D and EGF domains. (927 aa) |
| | Celsr1 | Cadherin, EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2741 aa) |
| | Nrxn2 | Neurexin-2; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. (1715 aa) |
| | Atrn | Attractin; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines (By similarity). May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system. (1432 aa) |
| | Nrg2 | Pro-neuregulin-2, membrane-bound isoform; Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. (860 aa) |
| | Ltbp4 | Latent-transforming growth factor beta-binding protein 4. (1631 aa) |
| | Ltbp3 | Latent-transforming growth factor beta-binding protein 3. (1253 aa) |
| | Tmem8a | Transmembrane protein 8 (Five membrane-spanning domains) (Predicted). (772 aa) |
| | Cntnap1 | Contactin-associated protein 1; Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells. (1381 aa) |
| | Tie1 | Tyrosine kinase with immunoglobulin-like and EGF-like domains 1. (1137 aa) |
| | Cd248 | CD248 antigen, endosialin (Predicted). (764 aa) |
| | Celsr2 | Cadherin EGF LAG seven-pass G-type receptor 2; Receptor that may have an important role in cell/cell signaling during nervous system formation; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. (2919 aa) |
| | F10 | Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting; Belongs to the peptidase S1 family. (494 aa) |
| | Proz | Protein Z, vitamin K-dependent plasma glycoprotein; Belongs to the peptidase S1 family. (406 aa) |
| | Egfl7 | Epidermal growth factor-like protein 7; Regulates vascular tubulogenesis in vivo. Inhibits platelet- derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis (By similarity). (279 aa) |
| | Notch1 | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination (By similarity). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (By similarity). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in angiogenesis; negatively regulates endothelial cell proliferation and mig [...] (2531 aa) |
| | Dll3 | Delta-like protein 3; Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). (589 aa) |
| | Plat | Tissue-type plasminogen activator chain A; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events; Belongs to the peptidase S1 family. (559 aa) |
| | Adam30 | ADAM metallopeptidase domain 30. (726 aa) |
| | Notch2 | Neurogenic locus notch homolog protein 2; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and pos [...] (2471 aa) |
| | Dlk2 | Protein delta homolog 2; Regulates adipogenesis. (382 aa) |
| | Bcan | Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Isoform 2 may function as a chondroitin sulfate-bearing cell surface receptor. (883 aa) |
| | Stab1 | Stabilin 1. (2252 aa) |
| | Hbegf | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (208 aa) |
| | Adam12 | ADAM metallopeptidase domain 12. (882 aa) |
| | Gas6 | Growth arrest-specific protein 6; Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses (By similarity). (674 aa) |
| | Hhip | Hedgehog-interacting protein. (700 aa) |
| | Adam8 | ADAM metallopeptidase domain 8. (823 aa) |
| | Adam18 | Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity). (717 aa) |
| | Fbln7 | Fibulin 7. (440 aa) |
| | Atrnl1 | Attractin-like 1. (1126 aa) |
| | Lama1 | Laminin subunit alpha 1. (3083 aa) |
| | Sned1 | Sushi, nidogen and EGF-like domain-containing protein 1. (1397 aa) |
| | Lrp5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1600 aa) |
| | Hyal3 | Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro [...] (412 aa) |
| | Lrp4 | Low-density lipoprotein receptor-related protein 4; Mediates SOST-dependent inhibition of bone formation (By similarity). Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling (By similarity). Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN- induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating d [...] (1905 aa) |
| | Tmem8b | Transmembrane protein 8B. (472 aa) |
| | Umod | Uromodulin, secreted form; [Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. (644 aa) |
| | Proc | Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (482 aa) |
| | Pear1 | Platelet endothelial aggregation receptor 1. (1033 aa) |
| | Jag2 | Protein jagged-2; Putative Notch ligand involved in the mediation of Notch signaling. May have a role in neurogenesis in the peripheral nervous system, limb development and in the adult brain. (1077 aa) |
| | Dll4 | Delta-like protein 4; Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate (By similarity). (686 aa) |
| | Matn4 | Matrilin 4 (Predicted), isoform CRA_b. (624 aa) |
| | Tll2 | Metalloendopeptidase. (1014 aa) |
| | Scube1 | Signal peptide, CUB domain and EGF-like domain-containing 1. (1018 aa) |
| | Tenm3 | Teneurin transmembrane protein 3. (2545 aa) |
| | Lrp8 | LDL receptor-related protein 8. (953 aa) |
| | Egflam | Pikachurin; Involved in both the normal retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity). (1005 aa) |
| | Masp2 | Mannan-binding lectin serine protease 2 A chain; Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. (685 aa) |
| | Pcsk5 | Proprotein convertase subtilisin/kexin type 5; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors. Belongs to the [...] (915 aa) |
| | Fat3 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. (4555 aa) |
| | Pcsk6 | Proprotein convertase subtilisin/kexin type 6; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues. (934 aa) |
| | Tenm4 | Teneurin transmembrane protein 4. (2794 aa) |
| | LOC100910977 | Disintegrin and metalloproteinase domain-containing protein 25-like. (759 aa) |
| | Lama2 | Laminin subunit alpha 2. (3121 aa) |
| | Mep1a | Meprin A subunit alpha. (748 aa) |
| | Matn1 | Matrilin 1, cartilage matrix protein. (498 aa) |
| | Thbs2 | Thrombospondin 2. (1172 aa) |
| | Plau | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. (432 aa) |
| | Ldlr | Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (879 aa) |
| | Hgfac | Hepatocyte growth factor activator. (653 aa) |
| | Creld1 | Protein disulfide isomerase Creld1; Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity). (420 aa) |
| | Tenm2 | Ten-2 intracellular domain; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer (By similarity). Acts as a ligand of the ADGRL1 receptor; Belongs to the tenascin family. Teneurin subfamily. (2603 aa) |
| | Jag1 | Protein jagged-1; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. May regulate fibroblast growth factor-induced angiogenesis. (1219 aa) |
| | Ptgs1 | Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. (602 aa) |
| | C8b | Complement component C8 beta chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. (589 aa) |
| | Slit3 | Slit homolog 3 protein; May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors. (1404 aa) |
| | Fbln2 | Fibulin 2, isoform CRA_a. (1221 aa) |
| | Nell2 | Protein kinase C-binding protein NELL2; Required for neuron survival through the modulation of MAPK pathways. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty. (819 aa) |
| | Lamb3 | Laminin, beta 3, isoform CRA_a. (1172 aa) |
| | Adam4 | A disintegrin and metalloprotease domain 4. (755 aa) |
| | Matn2 | Matrilin 2. (941 aa) |
| | Lamb1 | Laminin subunit beta 1. (1786 aa) |
| | Adam19 | ADAM metallopeptidase domain 19. (920 aa) |
| | Megf9 | EGF-like-domain, multiple 5 (Predicted). (599 aa) |
| | Fbln5 | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Belongs to the fibulin family. (448 aa) |
| | Tpo | Thyroid peroxidase; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). (914 aa) |
| | Wif1 | Wnt inhibitory factor 1; Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. (379 aa) |
| | Creld2 | Protein disulfide isomerase Creld2; Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity). (349 aa) |
| | Thbd | Thrombomodulin. (577 aa) |
| | Adgre5 | Adhesion G protein-coupled receptor E5; Belongs to the G-protein coupled receptor 2 family. (903 aa) |
| | Vasn | RCG49849. (673 aa) |
| | Efemp1 | EGF-containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth; Belongs to the fibulin family. (493 aa) |
| | F9 | Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family. (462 aa) |
| | Nagpa | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (516 aa) |
| | Sell | L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia; Belongs to the selectin/LECAM family. (430 aa) |
| | Scarf2 | Scavenger receptor class F, member 2 (Predicted). (833 aa) |
| | Nid2 | Nidogen-2; Cell adhesion glycoprotein. Might be involved in osteoblast differentiation. It probably has a role in cell-extracellular matrix interactions (By similarity). (1438 aa) |
| | Notch4 | Notch homolog 4, isoform CRA_b. (1961 aa) |
| | Scube3 | Signal peptide, CUB domain and EGF-like domain-containing 3. (994 aa) |
| | Lama4 | Laminin subunit alpha 4. (1773 aa) |
| | Heg1 | Heart development protein with EGF-like domains 1. (1317 aa) |
| | Muc13 | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling. (547 aa) |
| | Masp1 | Mannan-binding lectin serine protease 1 heavy chain; Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of [...] (704 aa) |
| | Fras1 | Fraser extracellular matrix complex subunit 1. (3857 aa) |
| | Tnn | Tenascin N. (1562 aa) |
| | Ptgs2 | Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa) |
| | Lamc1 | Laminin subunit gamma 1. (1607 aa) |
| | Btc | Betacellulin. (177 aa) |
| | Areg | Amphiregulin; Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts. (243 aa) |
| | Ereg | Proepiregulin; Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation. (162 aa) |
| | Epgn | Epithelial mitogen. (138 aa) |
| | Itgb8 | Integrin beta; Belongs to the integrin beta chain family. (767 aa) |
