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| | Fyn | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa) |
| | Stam | Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1. (547 aa) |
| | Macf1 | Microtubule-actin cross-linking factor 1; F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesion [...] (7384 aa) |
| | Sh3glb2 | Endophilin-B2; Belongs to the endophilin family. (400 aa) |
| | Myo1e | Unconventional myosin-Ie; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function (By similarity). In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles alon [...] (998 aa) |
| | Samsn1 | SAM domain, SH3 domain and nuclear localization signals, 1. (372 aa) |
| | Mapk8ip1 | C-Jun-amino-terminal kinase-interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fu [...] (699 aa) |
| | Trip10 | Cdc42-interacting protein 4; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Also acts as a link between CDC42 signaling and regulation of the actin cytoskeleton. Binds to lipids such as phosphatidylinositol 4,5- bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization in the vicinity of membrane tubules by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization and dynamin may promote the fission of membrane tubules [...] (600 aa) |
| | Dlg4 | Disks large homolog 4; Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated stat [...] (729 aa) |
| | Zdhhc6 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (413 aa) |
| | Sh3glb1 | Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 d [...] (384 aa) |
| | LOC100910792 | Uncharacterized protein. (614 aa) |
| | Plec | Plectin; Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics; Belongs to the plakin or cytolinker family. (4688 aa) |
| | Mpp2 | MAGUK p55 subfamily member 2; Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density. In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (By similarity). (552 aa) |
| | Cacnb1 | Voltage-dependent L-type calcium channel subunit beta-1; Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore- forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (Probable). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subun [...] (642 aa) |
| | Mpp6 | Membrane palmitoylated protein 6; Belongs to the MAGUK family. (557 aa) |
| | Rimbp2 | RIMS-binding protein 2; Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B; Belongs to the RIMBP family. (1238 aa) |
| | Cacnb3 | Voltage-dependent L-type calcium channel subunit beta-3; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation. (484 aa) |
| | Sh3gl3 | Endophilin-A3; Implicated in endocytosis. May recruit other proteins to membranes with high curvature. (347 aa) |
| | Sla | Src-like-adapter; Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins (By similarity). (312 aa) |
| | Tjp1 | Tight junction protein ZO-1; TjpP1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role [...] (1765 aa) |
| | Cask | Peripheral plasma membrane protein CASK; Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1; Belongs to the MAGUK family. (909 aa) |
| | Fchsd2 | FCH and double SH3 domains 2. (762 aa) |
| | Arhgap12 | Rho GTPase-activating protein 12. (838 aa) |
| | Sptan1 | Spectrin alpha chain, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Belongs to the spectrin family. (2498 aa) |
| | Dlg1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. During long-term depression in hippocampal neurons, it recruits ADAM10 to the pl [...] (917 aa) |
| | Src | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (542 aa) |
| | Myo15a | Myosin XVA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3508 aa) |
| | Btk | Tyrosine-protein kinase. (662 aa) |
| | Mpp3 | MAGUK p55 subfamily member 3. (585 aa) |
| | Shank3 | SH3 and multiple ankyrin repeat domains protein 3; Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex [...] (1741 aa) |
| | Nedd9 | Neural precursor cell-expressed, developmentally down-regulated 9. (897 aa) |
| | Tnk2 | Activated CDC42 kinase 1; Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting [...] (1055 aa) |
| | Pacsin3 | Protein kinase C and casein kinase substrate in neurons 3. (424 aa) |
| | Sh3pxd2a | SH3 and PX domains 2A. (1109 aa) |
| | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Plays a role in ciliogenesis (By similarity). (1086 aa) |
| | Pacsin1 | Protein kinase C and casein kinase substrate in neurons protein 1; Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell corte [...] (441 aa) |
| | Plcg1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). (1290 aa) |
| | Plcg2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. (1265 aa) |
| | Arhgef37 | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). (676 aa) |
| | rCG_54231 | RCG54231. (85 aa) |
| | Mia3 | Uncharacterized protein. (1377 aa) |
| | Arhgap4 | Rho GTPase activating protein 4, isoform CRA_a. (955 aa) |
| | Stac2 | SH3 and cysteine rich domain 2 (Predicted), isoform CRA_a. (408 aa) |
| | Srgap2 | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] (1071 aa) |
| | Pex13 | Peroxisomal biogenesis factor 13 (Predicted). (403 aa) |
| | Neb | Nebulin. (6666 aa) |
| | Rusc2 | RUN and SH3 domain-containing 2. (1321 aa) |
| | Sh3gl1 | Endophilin-A2; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity); Belongs to the endophilin family. (368 aa) |
| | Arhgef16 | Rho guanine nucleotide exchange factor 16. (709 aa) |
| | Snx9 | Sorting nexin. (593 aa) |
| | Shank2 | SH3 and multiple ankyrin repeat domains protein 2; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. (1839 aa) |
| | Itsn2 | Intersectin 2. (1716 aa) |
| | Sh3rf3 | SH3 domain-containing ring finger 3. (694 aa) |
| | Vav1 | Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. (843 aa) |
| | Dnmbp | Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (By similarity). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi. (1577 aa) |
| | Eps8l3 | EPS8-like 3 (Predicted). (600 aa) |
| | Snx18 | Sorting nexin. (615 aa) |
| | Tjp2 | Tight junction protein 2; Belongs to the MAGUK family. (1164 aa) |
| | Nostrin | Nostrin; Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. (502 aa) |
| | Pstpip1 | Proline-serine-threonine phosphatase-interacting protein 1. (416 aa) |
| | Arhgef19 | Rho guanine nucleotide exchange factor (GEF) 19 (Predicted), isoform CRA_a. (888 aa) |
| | Spta1 | Spectrin, alpha, erythrocytic 1. (2416 aa) |
| | Nebl | Nebulette. (1015 aa) |
| | Sh3yl1 | SH3 domain-containing YSC84-like protein 1. (340 aa) |
| | Pacsin2 | Protein kinase C and casein kinase substrate in neurons 2 protein; Regulates the morphogenesis and endocytosis of caveolae. Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. (488 aa) |
| | Nphp1 | Nephronophthisis 1 (Juvenile) homolog (Human) (Predicted). (457 aa) |
| | Baiap2l1 | Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity). (516 aa) |
| | Pram1 | PML-RARA-regulated adaptor molecule 1. (668 aa) |
| | Dock2 | Uncharacterized protein; Belongs to the DOCK family. (846 aa) |
| | Abl2 | Tyrosine-protein kinase. (1208 aa) |
| | Cacnb4 | Voltage-dependent L-type calcium channel subunit beta-4; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. (486 aa) |
| | rCG_61997 | RCG61997. (524 aa) |
| | Dock5 | Dedicator of cytokinesis 5; Belongs to the DOCK family. (1868 aa) |
| | Arhgap9 | Rho GTPase-activating protein 9. (639 aa) |
| | Rimbp3 | RIMS-binding protein 3. (1612 aa) |
| | Abi1 | Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl- mediated phosphorylation of ENAH. Recru [...] (481 aa) |
| | Tnk1 | Tyrosine kinase, non-receptor, 1 (Predicted); Belongs to the protein kinase superfamily. Tyr protein kinase family. (667 aa) |
| | Macc1 | MET transcriptional regulator MACC1. (850 aa) |
| | Yes1 | Tyrosine-protein kinase Yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components su [...] (541 aa) |
| | Mapk8ip2 | C-Jun-amino-terminal kinase-interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. (835 aa) |
| | Fnbp1l | Formin-binding protein 1-like; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similari [...] (605 aa) |
| | LOC102556447 | Rho guanine nucleotide exchange factor 38-like. (219 aa) |
| | Dlg2 | Disks large homolog 2; Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity); Belongs to the MAGUK family. (787 aa) |
| | Sh3d21 | SH3 domain-containing 21. (544 aa) |
| | Ppp1r13l | Protein phosphatase 1, regulatory subunit 13-like. (825 aa) |
| | Arhgef38 | Uncharacterized protein. (706 aa) |
| | Cttn | Src substrate cortactin; Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (By similarity). Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-bas [...] (546 aa) |
| | Abi2 | Abl-interactor 2. (534 aa) |
| | Fnbp1 | Formin-binding protein 1; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL (By s [...] (632 aa) |
| | Nckipsd | NCK-interacting protein with SH3 domain. (705 aa) |
| | Arhgef5 | Rho guanine nucleotide exchange factor 5. (1567 aa) |
| | Rasa1 | Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21 (By similarity). (996 aa) |
| | Itsn1 | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] (1713 aa) |
| | Abl1 | Tyrosine-protein kinase. (1143 aa) |
| | Arhgef7 | Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). (862 aa) |
| | Dst | Dystonin. (7512 aa) |
| | Prmt2 | HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae), isoform CRA_c; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (445 aa) |
| | Caskin1 | Caskin-1; May link the scaffolding protein CASK to downstream intracellular effectors. (1430 aa) |
| | Bcar1 | Breast cancer anti-estrogen resistance protein 1; Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration (By similarity). (968 aa) |
| | Kalrn | Kalirin; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation. (2977 aa) |
| | Arhgap42 | Rho GTPase-activating protein 42. (826 aa) |
| | Cacnb2 | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. (611 aa) |
| | Cass4 | Cas scaffold protein family member 4. (808 aa) |
| | Eps8l1 | EPS8-like 1 (Predicted). (717 aa) |
| | Arhgap27 | Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1. (869 aa) |
| | Arhgap33 | Rho GTPase-activating protein 33. (1310 aa) |
| | Otor | Otoraplin (Predicted). (128 aa) |
| | Skap1 | Src kinase-associated phosphoprotein 1; Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway (By similarity). Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. Belongs to the SKAP family. (354 aa) |
| | Stam2 | Signal transducing adapter molecule 2; Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking process [...] (523 aa) |
| | Noxo1 | NADPH oxidase organizer 1 (Predicted). (235 aa) |
| | D3ZUF0_RAT | Uncharacterized protein. (504 aa) |
| | Map3k10 | Mitogen-activated protein kinase kinase kinase 10; Activates the JUN N-terminal pathway. (940 aa) |
| | Txk | Tyrosine-protein kinase. (526 aa) |
| | Sorbs2 | Sorbin and SH3 domain-containing protein 2; Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (By similarity). Isoform 2 increases water and sodium absorption in the intestine and gall-bladder. (1196 aa) |
| | Map3k11 | Mitogen-activated protein kinase kinase kinase 11; Activates the JUN N-terminal pathway. Required for serum- stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen- stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity). (850 aa) |
| | Tjp3 | Tight junction protein 3 (Predicted), isoform CRA_b; Belongs to the MAGUK family. (907 aa) |
| | Vav3 | Vav guanine nucleotide exchange factor 3. (847 aa) |
| | Matk | Megakaryocyte-associated tyrosine-protein kinase; Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC- family members in brain. (467 aa) |
| | Sla2 | Similar to Src-like adaptor protein-2 (Predicted). (263 aa) |
| | Map3k21 | Mitogen-activated protein kinase kinase kinase. (994 aa) |
| | Fchsd1 | FCH and double SH3 domains 1 (Predicted), isoform CRA_b. (690 aa) |
| | Csk | Tyrosine-protein kinase CSK; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins [...] (450 aa) |
| | Sh3bp4 | SH3 domain-binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity). (961 aa) |
| | Pik3r2 | Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein- tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating t [...] (722 aa) |
| | Sh3tc2 | SH3 domain and tetratricopeptide repeats 2. (1311 aa) |
| | Shank1 | SH3 and multiple ankyrin repeat domains protein 1; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function. (2167 aa) |
| | Pik3r1 | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (724 aa) |
| | Mpp7 | MAGUK p55 subfamily member 7; Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity). (576 aa) |
| | Sh3rf2 | E3 ubiquitin-protein ligase SH3RF2; Has E3 ubiquitin-protein ligase activity. Acts as an anti- apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro- apoptotic JNK activation. Facilitates TNF-alpha- mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin- mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity (By similarity). (735 aa) |
| | Sgsm3 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. May act as a modulator of small G protein RAB- and RAP-mediated neuronal signal transduction and vesicular transportation pathways (By similarity). (763 aa) |
| | Eps8l2 | Eps8l2 protein. (729 aa) |
| | Grap2 | GRB2-related adaptor protein 2. (327 aa) |
| | Snx33 | Sorting nexin. (574 aa) |
| | Nck2 | Cytoplasmic protein. (380 aa) |
| | Efs | Embryonal Fyn-associated substrate (Predicted). (561 aa) |
| | Ngef | Ephexin-1; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension. (616 aa) |
| | Myo7b | Myosin VIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2152 aa) |
| | Dock3 | Dedicator of cyto-kinesis 3; Belongs to the DOCK family. (2071 aa) |
| | Arhgef26 | Rho guanine nucleotide exchange factor 26. (869 aa) |
| | Ahi1 | Jouberin; Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development. (1047 aa) |
| | Myo7a | Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2177 aa) |
| | Arhgef4 | Similar to Rho guanine nucleotide exchange factor 4 isoform a, isoform CRA_a. (484 aa) |
| | Dsp | Desmoplakin. (2877 aa) |
| | Fyb1 | FYN-binding protein 1; Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (By similarity). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. (830 aa) |
| | Spata13 | Spermatogenesis-associated 13. (1245 aa) |
| | Arhgap10 | Rho GTPase-activating protein 10. (786 aa) |
| | Sash1 | SAM and SH3 domain-containing 1. (1073 aa) |
| | Srms | Tyrosine-protein kinase. (507 aa) |
| | Bin1 | Myc box-dependent-interacting protein 1; Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (By similarity). Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of B [...] (589 aa) |
| | Dbnl | Drebrin-like protein; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis [...] (436 aa) |
| | Ptk6 | Tyrosine-protein kinase. (451 aa) |
| | Amph | Amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity). (681 aa) |
| | Ostf1 | Osteoclast-stimulating factor 1; Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity. (214 aa) |
| | Trio | Triple functional domain protein; Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth (By similarity). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA- selective glutamate receptors (AMPARs) at CA1 excitatory synapses. May act as a regulator of adipogenesis (By similarity); Belongs to the protein kinase s [...] (3053 aa) |
| | Skap2 | Src kinase-associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway (By similarity). Belongs to the SKAP family. (358 aa) |
| | Baiap2l2 | BAI1-associated protein 2-like 2. (521 aa) |
| | Cd2ap | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (By similarity). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen- presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glo [...] (637 aa) |
| | Blk | Tyrosine-protein kinase. (499 aa) |
| | Mpp4 | MAGUK p55 subfamily member 4; May play a role in retinal photoreceptors development. (635 aa) |
| | Sh3rf1 | E3 ubiquitin-protein ligase SH3RF1; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin- dependent and clathrin-independent endocytosis (By similarity). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the [...] (894 aa) |
| | Fgr | Tyrosine-protein kinase Fgr; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCER1G and FCGR2. Acts downs [...] (517 aa) |
| | Lck | Proto-oncogene tyrosine-protein kinase LCK; Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T- cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen- bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associa [...] (520 aa) |
| | Hck | Tyrosine-protein kinase HCK; Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic p [...] (503 aa) |
| | Noxa1 | NADPH oxidase activator 1; Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3 (By similarity). (446 aa) |
| | Evpl | Envoplakin (Predicted). (2029 aa) |
| | Sorbs3 | Sorbin and SH3 domain containing 3, isoform CRA_b. (733 aa) |
| | Mpp5 | MAGUK p55 subfamily member 5; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required [...] (675 aa) |
| | Stac | SH3 and cysteine-rich domain. (367 aa) |
| | Arhgap32 | Rho GTPase-activating protein 32. (2101 aa) |
| | Myo1f | Myosin IF (Predicted); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1098 aa) |
| | Fut8 | Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. (575 aa) |
| | Lyn | Tyrosine-protein kinase Lyn; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-c [...] (512 aa) |
| | Ubash3b | Ubiquitin-associated and SH3 domain-containing, B. (638 aa) |
| | Sh3tc1 | SH3 domain and tetratricopeptide repeats 1 (Predicted). (1345 aa) |
| | Tspoap1 | Peripheral-type benzodiazepine receptor-associated protein 1. (1845 aa) |
| | Stac3 | SH3 and cysteine rich domain 3 (Predicted). (361 aa) |
| | Vav2 | Vav guanine nucleotide exchange factor 2. (868 aa) |
| | Map3k9 | Mitogen-activated protein kinase kinase kinase. (1100 aa) |
| | Ncf4 | Similar to neutrophil cytosolic factor 4, isoform CRA_a. (339 aa) |
| | Eps8 | Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and acti [...] (822 aa) |
| | Itk | Tyrosine-protein kinase. (620 aa) |
| | Srgap3 | SLIT-ROBO Rho GTPase-activating protein 3. (1099 aa) |
| | Sh3gl2 | Endophilin-A1; Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (By similarity). (352 aa) |
| | Abi3 | ABI gene family, member 3, isoform CRA_b. (367 aa) |
| | Dlg5 | Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1815 aa) |
| | Sh3kbp1 | SH3 domain-containing kinase-binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3- kinase ac [...] (684 aa) |
| | Crk | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. (304 aa) |
| | Srgap1 | SLIT-ROBO Rho GTPase-activating protein 1. (1085 aa) |
| | Sash3 | Similar to RIKEN cDNA 1200013B08 (Predicted). (380 aa) |
| | Caskin2 | Cask-interacting protein 2 (Predicted). (1200 aa) |
| | Baiap2 | Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling whe [...] (535 aa) |
| | Lasp1 | LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin- based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types. (263 aa) |
| | Sh3pxd2b | SH3 and PX domains 2B. (804 aa) |
| | Grb2 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. (217 aa) |
| | Tp53bp2 | Tumor protein p53-binding protein, 2. (1128 aa) |
| | LOC100910506 | Uncharacterized protein. (356 aa) |
| | Ppl | Periplakin (Predicted). (1754 aa) |
| | Dlg3 | Disks large homolog 3; Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling; Belongs to the MAGUK family. (849 aa) |
| | Grap | GRB2-related adaptor protein. (217 aa) |
| | Hcls1 | Hematopoietic cell-specific LYN substrate 1. (476 aa) |
| | Crkl | Crk-like protein; May mediate the transduction of intracellular signals. Belongs to the CRK family. (303 aa) |
| | Mia | Melanoma-derived growth regulatory protein; May function during cartilage development and maintenance; Belongs to the MIA/OTOR family. (130 aa) |
| | Ncf1 | Neutrophil cytosolic factor 1; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). (389 aa) |
| | Ubash3a | Ubiquitin-associated and SH3 domain-containing, A. (624 aa) |
| | Arhgef6 | Rho guanine nucleotide exchange factor 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF). (796 aa) |
| | Frk | Tyrosine-protein kinase FRK; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity). (506 aa) |
| | Sh3d19 | Similar to SH3 domain protein D19 (Predicted). (789 aa) |
| | Ppp1r13b | Protein phosphatase 1, regulatory subunit 13B. (1085 aa) |
| | Tec | Tyrosine-protein kinase. (674 aa) |
| | Mcf2l | Guanine nucleotide exchange factor DBS; Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus. (1179 aa) |
