STRINGSTRING
Asb16 Asb16 Asb6 Asb6 Asb10 Asb10 Asb9 Asb9 Cish Cish Asb18 Asb18 Rab40b Rab40b Socs6 Socs6 Asb15 Asb15 Asb5 Asb5 Asb3 Asb3 Socs7 Socs7 Spsb1 Spsb1 Asb2 Asb2 Asb17 Asb17 Wsb2 Wsb2 Socs1 Socs1 Socs3 Socs3 Asb12 Asb12 Socs2 Socs2 Asb8 Asb8 Socs4 Socs4 Spsb4 Spsb4 Wsb1 Wsb1 Asb14 Asb14 Socs5 Socs5 Spsb2 Spsb2 Spsb3 Spsb3 Neurl2 Neurl2 Asb13 Asb13 Tulp4 Tulp4 Rab40c Rab40c Asb1 Asb1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Asb16Similar to ankyrin repeat domain-containing SOCS box protein Asb-16 (Predicted). (453 aa)
Asb6Ankyrin repeat and SOCS box-containing 6. (345 aa)
Asb10Similar to ankyrin repeat-containing SOCS box protein 10 (Predicted). (465 aa)
Asb9Ankyrin repeat and SOCS box-containing 9. (344 aa)
CishCytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity). May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subs [...] (257 aa)
Asb18Ankyrin repeat and SOCS box-containing 18. (466 aa)
Rab40bRab40b, member RAS oncogene family (Predicted). (279 aa)
Socs6Suppressor of cytokine-signaling 6. (547 aa)
Asb15Ankyrin repeat and SOCS box-containing 15. (583 aa)
Asb5Similar to ankyrin repeat and SOCs box-containing protein 5. (314 aa)
Asb3Ankyrin repeat and SOCS box-containing 3. (524 aa)
Socs7Suppressor of cytokine-signaling 7. (577 aa)
Spsb1SplA/ryanodine receptor domain and SOCS box containing 1 (Predicted). (273 aa)
Asb2Ankyrin repeat and SOCS box protein 2; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. (634 aa)
Asb17Ankyrin repeat and SOCS box containing protein 17. (295 aa)
Wsb2WD repeat and SOCS box-containing 2. (404 aa)
Socs1Suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an [...] (212 aa)
Socs3Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL [...] (225 aa)
Asb12Ankyrin repeat and SOCS box-containing 12. (308 aa)
Socs2Suppressor of cytokine signaling 2; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). (241 aa)
Asb8Ankyrin repeat and SOCS box-containing protein 8 (Predicted), isoform CRA_a. (288 aa)
Socs4Suppressor of cytokine signaling 4 (Predicted). (436 aa)
Spsb4SplA/ryanodine receptor domain and SOCS box containing 4 (Predicted). (273 aa)
Wsb1WD repeat and SOCS box-containing 1, isoform CRA_b. (421 aa)
Asb14Ankyrin repeat and SOCS box protein 14; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (594 aa)
Socs5Suppressor of cytokine-signaling 5. (536 aa)
Spsb2SPRY domain-containing SOCS box protein 2; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). (264 aa)
Spsb3SplA/ryanodine receptor domain and SOCS box containing 3 (Predicted). (391 aa)
Neurl2Neuralized-like 2 (Drosophila) (Predicted). (285 aa)
Asb13Ankyrin repeat and SOCS box-containing 13 (Predicted), isoform CRA_b. (278 aa)
Tulp4Similar to tubby super-family protein (Predicted). (1546 aa)
Rab40cRab40c, member RAS oncogene family. (281 aa)
Asb1Ankyrin repeat and SOCS box-containing protein 1 (Predicted), isoform CRA_a. (335 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.