STRINGSTRING
Agap3 Agap3 Rab36 Rab36 Rac1 Rac1 Rasl11a Rasl11a Ran Ran Rab8b Rab8b Rhobtb2 Rhobtb2 Rab34 Rab34 Rhot1 Rhot1 Arhgap5 Arhgap5 Agap1 Agap1 Rhebl1 Rhebl1 Cplane2 Cplane2 Rab20 Rab20 Rab25 Rab25 Rab5c Rab5c Cdc42 Cdc42 Rhoj Rhoj Agap2 Agap2 Rab35 Rab35 Rrad Rrad Rab27b Rab27b Rab7a Rab7a Rhobtb3 Rhobtb3 Rras2 Rras2 Rab33b Rab33b Rala Rala Rhov Rhov Rap2b Rap2b Rasd2 Rasd2 Rab8a Rab8a Rhoq Rhoq Arhgap35 Arhgap35 Hras Hras Rab38 Rab38 Rerg Rerg Rnd2 Rnd2 Rras Rras Nras Nras Rhog Rhog Rab40c Rab40c Rhot2 Rhot2 Rab3a Rab3a Rhod Rhod Rab18 Rab18 Rit2 Rit2 Rab14 Rab14 Rab6a Rab6a Nkiras2 Nkiras2 Rab21 Rab21 Rasd1 Rasd1 Rab26 Rab26 Rhoh Rhoh Rap2c Rap2c Ralb Ralb Rasl11b Rasl11b Rab44 Rab44 Rab4b Rab4b Rnd3 Rnd3 Rhob Rhob Ift27 Ift27 Rab2a Rab2a Rab33a Rab33a Rab7b Rab7b Rap1b Rap1b Rac2 Rac2 Rab15 Rab15 Rem1 Rem1 Rab11b Rab11b Rab3b Rab3b Rergl Rergl Nkiras1 Nkiras1 Rab39a Rab39a Rab19 Rab19 Kras Kras Rab43 Rab43 Rab11a Rab11a Rab3d Rab3d Rab3c Rab3c Rem2 Rem2 Rasl2-9 Rasl2-9 Rabl2 Rabl2 Rap1a Rap1a Rasl12 Rasl12 RGD1306195 RGD1306195 Mras Mras Diras1 Diras1 Eras Eras Rab4a Rab4a Rab9a Rab9a Rab40b Rab40b Rasef Rasef Rab2b Rab2b Rab5b Rab5b Rab12 Rab12 Rab22a Rab22a RSA-14-44 RSA-14-44 Rab31 Rab31 Rhof Rhof Rheb Rheb Rac3 Rac3 Rab10 Rab10 Rab9b Rab9b Rhoa Rhoa Rab29 Rab29 M0RDE4_RAT M0RDE4_RAT Rab1b Rab1b Mxd3 Mxd3 Rasl10b Rasl10b Rab6b Rab6b Rab30 Rab30 Rap2a Rap2a Rab27a Rab27a Lrrc45 Lrrc45 Rab5al1 Rab5al1 Rhobtb1 Rhobtb1 Cracr2a Cracr2a Rnd1 Rnd1 Rab37 Rab37 Rab28 Rab28 Rab13 Rab13 Rab1a Rab1a Rab23 Rab23 Dnajc27 Dnajc27
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 3. (812 aa)
Rab36RAB36, member RAS oncogene family. (267 aa)
Rac1Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] (192 aa)
Rasl11aRas-like protein family member 11A; Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity). (269 aa)
RanGTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (216 aa)
Rab8bRas-related protein Rab-8B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells. (207 aa)
Rhobtb2Rho-related BTB domain-containing 2. (728 aa)
Rab34Ras-related protein Rab-34; Protein transport. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes. Involved in the redistribution of lysosomes to the peri-Golgi region. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function. (258 aa)
Rhot1Ras homolog family member T1. (752 aa)
Arhgap5Rho-GTPase-activating protein 5. (1503 aa)
Agap1ArfGAP with GTPase domain, ankyrin repeat and PH domain 1. (889 aa)
Rhebl1GTPase RhebL1; Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2 (By similarity). (183 aa)
Cplane2Similar to novel protein (Predicted), isoform CRA_b. (258 aa)
Rab20RAB20, member RAS oncogene family. (232 aa)
Rab25RAB25, member RAS oncogene family (Predicted), isoform CRA_b. (213 aa)
Rab5cRas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (216 aa)
Cdc42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase (By similarity). Regulates cell migration (By similarity). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface proj [...] (191 aa)
RhojRas homolog gene family, member J. (211 aa)
Agap2Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. (1186 aa)
Rab35Ras-related protein Rab-35; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required f [...] (201 aa)
RradGTP-binding protein RAD; May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D (By similarity). (307 aa)
Rab27bRas-related protein Rab-27B; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1. May be involved in targeting uroplakins to urothelial apical membranes. (218 aa)
Rab7aRas-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (207 aa)
Rhobtb3Rho-related BTB domain containing 3 (Predicted), isoform CRA_b. (611 aa)
Rras2Related RAS viral (R-ras) oncogene homolog 2. (204 aa)
Rab33bRAB33B, member of RAS oncogene family (Predicted), isoform CRA_b. (229 aa)
RalaRas-related protein Ral-A; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (By similarity). Th [...] (206 aa)
RhovRho-related GTP-binding protein RhoV; Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway; Belongs to the small GTPase superfamily. Rho family. (276 aa)
Rap2bRas-related protein Rap-2b; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells (By similarity). (183 aa)
Rasd2GTP-binding protein Rhes; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. (266 aa)
Rab8aRas-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa)
RhoqRho-related GTP-binding protein RhoQ; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. (205 aa)
Arhgap35Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis. Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similar [...] (1513 aa)
HrasGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
Rab38Rab38, member of RAS oncogene family. (211 aa)
RergSimilar to RAS-like, estrogen-regulated, growth-inhibitor (Predicted). (199 aa)
Rnd2Rho family GTPase 2, isoform CRA_b. (228 aa)
RrasRas-related protein R-Ras; Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity. Belongs to the small GTPase superfamily. Ras family. (218 aa)
NrasGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
RhogRas homolog gene family, member G (Rho G). (191 aa)
Rab40cRab40c, member RAS oncogene family. (281 aa)
Rhot2Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (622 aa)
Rab3aRas-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed. Stimulates insulin secretion through in [...] (220 aa)
RhodRas homolog gene family, member D (Predicted), isoform CRA_b. (210 aa)
Rab18Ras-related protein Rab-18; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity). (206 aa)
Rit2GTP-binding protein Rit2; Binds and exchanges GTP and GDP; Belongs to the small GTPase superfamily. Ras family. (217 aa)
Rab14Ras-related protein Rab-14; Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B [...] (215 aa)
Rab6aRas-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER. Belongs to the small GTPase superfamily. Rab family. (208 aa)
Nkiras2NFKB inhibitor interacting Ras-like protein 2 (Predicted), isoform CRA_a. (191 aa)
Rab21Ras-related protein Rab-21; Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (By similarity). Involved in neurite growth. Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal tran [...] (223 aa)
Rasd1Dexamethasone-induced Ras-related protein 1; Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65. (280 aa)
Rab26Ras-related protein Rab-26; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similari [...] (257 aa)
RhohRas homolog gene family, member H. (191 aa)
Rap2cRAP2C, member of RAS oncogene family. (183 aa)
RalbRas-related protein Ral-B; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Required for suppression of apoptosis (By similarity). In late stages of cy [...] (205 aa)
Rasl11bRas-like protein family member 11B; Belongs to the small GTPase superfamily. Ras family. (247 aa)
Rab44RAB44, member RAS oncogene family. (722 aa)
Rab4bRas-related protein Rab-4B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (213 aa)
Rnd3Rho-related GTP-binding protein RhoE; Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. (244 aa)
RhobRho-related GTP-binding protein RhoB; Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascul [...] (196 aa)
Ift27RAB, member of RAS oncogene family-like 4 (Predicted). (186 aa)
Rab2aRas-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex. (206 aa)
Rab33aRAB33A, member of RAS oncogene family (Predicted). (237 aa)
Rab7bSimilar to RAB7-like protein (Predicted), isoform CRA_b. (199 aa)
Rap1bRas-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
Rac2Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2). (192 aa)
Rab15Ras-related protein Rab-15; May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal; Belongs to the small GTPase superfamily. Rab family. (212 aa)
Rem1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (297 aa)
Rab11bRas-related protein Rab-11B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regul [...] (218 aa)
Rab3bRas-related protein Rab-3B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (219 aa)
RerglRERG-like. (204 aa)
Nkiras1NFKB inhibitor interacting Ras-like protein 1 (Predicted), isoform CRA_a. (192 aa)
Rab39aRAB39, member RAS oncogene family (Predicted). (217 aa)
Rab19Ras-related protein Rab-19. (217 aa)
KrasGTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity). (189 aa)
Rab43Ras-related protein Rab-43; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga [...] (210 aa)
Rab11aRas-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...] (216 aa)
Rab3dGTP-binding protein Rab-3D; Protein transport. Probably involved in regulated exocytosis (By similarity); Belongs to the small GTPase superfamily. Rab family. (219 aa)
Rab3cRas-related protein Rab-3C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (227 aa)
Rem2GTP-binding protein REM 2; Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis. (341 aa)
Rasl2-9GTP-binding nuclear protein Ran, testis-specific isoform; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). (216 aa)
Rabl2RAB, member of RAS oncogene family-like 2. (250 aa)
Rap1aRas-related protein Rap-1A; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular [...] (184 aa)
Rasl12RAS-like, family 12 (Predicted). (266 aa)
RGD1306195GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
MrasRas-related protein M-Ras; Serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway (By similarity); Belongs to the small GTPase superfamily. Ras family. (208 aa)
Diras1DIRAS family GTPase 1. (198 aa)
ErasGTPase ERas. (227 aa)
Rab4aRas-related protein Rab-4A; Protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling. (218 aa)
Rab9aRas-related protein Rab-9A; Involved in the transport of proteins between the endosomes and the trans-Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. (201 aa)
Rab40bRab40b, member RAS oncogene family (Predicted). (279 aa)
RasefRAS and EF hand domain-containing. (709 aa)
Rab2bRAB2B, member RAS oncogene family. (215 aa)
Rab5bRAB5B, member RAS oncogene family (Predicted), isoform CRA_c. (215 aa)
Rab12Ras-related protein Rab-12; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By simi [...] (245 aa)
Rab22aRAB22A, member RAS oncogene family (Predicted), isoform CRA_b. (194 aa)
RSA-14-44RSA-14-44 protein. (193 aa)
Rab31Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] (195 aa)
RhofRas homolog family member F, filopodia-associated. (211 aa)
RhebGTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rheb family. (183 aa)
Rac3Rac family small GTPase 3. (192 aa)
Rab10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...] (200 aa)
Rab9bRAB9B, member RAS oncogene family. (201 aa)
RhoaTransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa)
Rab29Ras-related protein Rab-7L1; The small GTPases Rab are key regulators in vesicle trafficking. Essential for maintaining the integrity of endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Regulates also neuronal process morphology in the intact central nervous system (CNS). (204 aa)
M0RDE4_RATUncharacterized protein. (186 aa)
Rab1bRas-related protein Rab-1B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates [...] (201 aa)
Mxd3RAB24, member RAS oncogene family. (203 aa)
Rasl10bRas-like protein family member 10B. (203 aa)
Rab6bRAB6B, member RAS oncogene family. (208 aa)
Rab30RAB30, member RAS oncogene family, isoform CRA_a. (203 aa)
Rap2aRAS related protein 2a. (183 aa)
Rab27aRas-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. (221 aa)
Lrrc45Leucine-rich repeat-containing 45. (735 aa)
Rab5al1Rab5a protein. (61 aa)
Rhobtb1Rho-related BTB domain-containing 1. (696 aa)
Cracr2aCalcium release activated channel regulator 2A. (310 aa)
Rnd1Rho family GTPase 1. (232 aa)
Rab37RAB37, member RAS oncogene family. (223 aa)
Rab28Ras-related protein Rab-28; Belongs to the small GTPase superfamily. Rab family. (221 aa)
Rab13Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regu [...] (203 aa)
Rab1aRAB1A, member RAS oncogene family. (323 aa)
Rab23RAB23, member RAS oncogene family (Predicted). (237 aa)
Dnajc27DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. (379 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.