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| | Trim65 | Tripartite motif-containing 65. (592 aa) |
| | Pcgf3 | Polycomb group ring finger 3. (241 aa) |
| | Rnf115 | Ring finger protein 115. (305 aa) |
| | Rnf5 | E3 ubiquitin-protein ligase RNF5; Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'- linked polyubiquitination [...] (180 aa) |
| | Ring1 | E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...] (406 aa) |
| | Rnf39 | RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance. (352 aa) |
| | Trim10 | Tripartite motif-containing 10. (489 aa) |
| | Trim39 | E3 ubiquitin-protein ligase TRIM39; E3 ubiquitin-protein ligase (By similarity). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similari [...] (488 aa) |
| | Lnx2 | Ligand of numb-protein X 2. (686 aa) |
| | Rnf6 | Ring finger protein 6. (667 aa) |
| | Rnft2 | Ring finger protein, transmembrane 2. (445 aa) |
| | Rnf34 | E3 ubiquitin-protein ligase RNF34; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p5 [...] (381 aa) |
| | Dtx2 | Deltex E3 ubiquitin ligase 2. (619 aa) |
| | Baz1b | Bromodomain adjacent to zinc finger domain protein 1B. (1476 aa) |
| | Ltn1 | Listerin E3 ubiquitin protein ligase 1. (1798 aa) |
| | Rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (566 aa) |
| | Lnx1 | Ligand of numb-protein X 1 (Predicted), isoform CRA_a. (728 aa) |
| | Rnf112 | RING finger protein 112; E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-ind [...] (674 aa) |
| | Trim7 | Tripartite motif-containing 7. (510 aa) |
| | Rchy1 | Ring finger and CHY zinc finger domain containing 1, isoform CRA_b. (261 aa) |
| | Rlim | Ring finger protein, LIM domain-interacting. (603 aa) |
| | Traf7 | TNF receptor-associated factor 7. (669 aa) |
| | Bfar | Bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (By similarity). (450 aa) |
| | Rnft1 | Ring finger protein, transmembrane 1. (397 aa) |
| | Rnf167 | E3 ubiquitin-protein ligase RNF167; May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin- conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition. (349 aa) |
| | Rag1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1040 aa) |
| | Traf6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (530 aa) |
| | Rnf145 | Ring finger protein 145. (664 aa) |
| | Rnf215 | Similar to RIKEN cDNA 0610009J22 (Predicted). (379 aa) |
| | Scaf11 | SR-related CTD-associated factor 11. (1439 aa) |
| | Birc3 | Baculoviral IAP repeat-containing 3. (638 aa) |
| | Ankib1 | RBR-type E3 ubiquitin transferase. (1085 aa) |
| | Trim54 | Tripartite motif-containing protein 54; May bind and stabilize microtubules during myotubes formation. (364 aa) |
| | Traf2 | TNF receptor-associated factor. (497 aa) |
| | Traip | TRAF-interacting protein. (469 aa) |
| | Trim37 | Tripartite motif protein 37 (Predicted). (1008 aa) |
| | Trim9 | E3 ubiquitin-protein ligase TRIM9; E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions (By similarity). May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. (710 aa) |
| | Cbll1 | Cbl proto-oncogene-like 1. (491 aa) |
| | Rnf144a | RBR-type E3 ubiquitin transferase. (292 aa) |
| | Rnf26 | Ring finger protein 26. (424 aa) |
| | Mnat1 | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa) |
| | Rnf43 | Ring finger protein 43. (782 aa) |
| | Marchf2 | E3 ubiquitin-protein ligase MARCHF2; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6. (246 aa) |
| | Trim47 | Similar to Tripartite motif protein 47. (642 aa) |
| | Pcgf1 | Polycomb group RING finger protein 1; Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell p [...] (259 aa) |
| | Pex2 | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family. (305 aa) |
| | Trim13 | E3 ubiquitin-protein ligase TRIM13; Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER- associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress- induced autophagy, and [...] (407 aa) |
| | Rnf227 | Similar to RIKEN cDNA A030009H04. (190 aa) |
| | Rc3h2 | Membrane associated DNA binding protein (Predicted). (1187 aa) |
| | Trim35 | Tripartite motif-containing protein 35; Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (By similarity). Implicated in the cell death mechanism (By similarity). (515 aa) |
| | Obi1 | Similar to chromosome 13 open reading frame 7 (Predicted). (724 aa) |
| | Mdm4 | Protein Mdm4; Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity). (490 aa) |
| | Mkrn1 | Makorin ring finger protein 1. (481 aa) |
| | Mkrn2 | Makorin, ring finger protein, 2. (417 aa) |
| | Rnf19a | RBR-type E3 ubiquitin transferase. (840 aa) |
| | Mkrn3 | Makorin, ring finger protein, 3. (528 aa) |
| | Arih1 | RBR-type E3 ubiquitin transferase. (555 aa) |
| | Trim32 | Tripartite motif-containing 32. (655 aa) |
| | Sh3rf1 | E3 ubiquitin-protein ligase SH3RF1; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin- dependent and clathrin-independent endocytosis (By similarity). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the [...] (894 aa) |
| | Cgrrf1 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. (332 aa) |
| | Trim59 | Tripartite motif-containing 59. (403 aa) |
| | Rnf208 | Ring finger protein 208. (265 aa) |
| | Birc2 | Baculoviral IAP repeat-containing 2. (589 aa) |
| | Mycbp2 | MYC-binding protein 2. (4538 aa) |
| | Uhrf2 | Ubiquitin-like, containing PHD and RING finger domains 2 (Predicted). (803 aa) |
| | Rnf146 | E3 ubiquitin-protein ligase RNF146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CA [...] (355 aa) |
| | Rnf7 | Ring finger protein 7 (Predicted). (113 aa) |
| | Trim23 | E3 ubiquitin-protein ligase TRIM23; Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes. (601 aa) |
| | Rnf181 | E3 ubiquitin-protein ligase RNF181; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (165 aa) |
| | Trim55 | Tripartite motif-containing protein 55; May regulate gene expression and protein turnover in muscle cells. (545 aa) |
| | Pcgf2 | Polycomb group ring finger 2 (Predicted), isoform CRA_a. (342 aa) |
| | Marchf8 | Membrane-associated ring finger (C3HC4) 8 (Predicted). (286 aa) |
| | Map3k1 | Mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase (By similarity). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. (1493 aa) |
| | Mib1 | Mindbomb E3 ubiquitin protein ligase 1. (1006 aa) |
| | Traf4 | TNF receptor-associated factor. (470 aa) |
| | Siah2 | E3 ubiquitin-protein ligase SIAH2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (By similarity). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (By simil [...] (325 aa) |
| | Rnf166 | E3 ubiquitin-protein ligase RNF166; E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates. In turn, participates in different biological processes including interferon production or autophagy. Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6. Plays also a role in the early recruitment of autophagy adapters to bacteria. Mediates 'Lys- 29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication. (237 aa) |
| | Rnf149 | Ring finger protein 149. (394 aa) |
| | Rnf151 | Ring finger protein 151 (Predicted). (238 aa) |
| | Irf2bp1 | Interferon regulatory factor 2 binding protein 1 (Predicted). (584 aa) |
| | Trim66 | Tripartite motif-containing 66. (1348 aa) |
| | Triml1 | Tripartite motif family-like 1. (470 aa) |
| | Shprh | SNF2 histone linker PHD RING helicase (Predicted). (1701 aa) |
| | Rnf152 | E3 ubiquitin-protein ligase RNF152; E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed. Belongs to the RNF152 family. (203 aa) |
| | Rnf183 | Ring finger protein 183. (190 aa) |
| | Siah1 | E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin- mediated degradation of many substrates, including proteins involved in transcription [...] (282 aa) |
| | Trim52 | Tripartite motif-containing 52. (235 aa) |
| | RGD1565844 | Similar to RIKEN cDNA 1700045I19. (211 aa) |
| | Rnf138 | E3 ubiquitin-protein ligase RNF138; E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex [...] (209 aa) |
| | Rfpl4a | Ret finger protein-like 4A. (285 aa) |
| | Mul1 | Similar to RIKEN cDNA 0610009K11 (Predicted), isoform CRA_b. (352 aa) |
| | Nsd2 | Nuclear receptor-binding SET domain protein 2. (1346 aa) |
| | Trim36 | Tripartite motif protein 36 (Predicted). (729 aa) |
| | Rnf25 | Ring finger protein 25. (454 aa) |
| | Trim6 | Tripartite motif-containing 6. (488 aa) |
| | Trim5 | Similar to 9230105E10Rik protein. (511 aa) |
| | Trim69 | E3 ubiquitin-protein ligase TRIM69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis. (499 aa) |
| | Rnf186 | Ring finger protein 186. (281 aa) |
| | Rnf214 | Ring finger protein 214. (703 aa) |
| | Mib2 | E3 ubiquitin-protein ligase MIB2; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. (953 aa) |
| | Mylip | E3 ubiquitin-protein ligase MYLIP; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. (445 aa) |
| | Rnf182 | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. (247 aa) |
| | rnf141 | RING finger protein 141; May be involved in spermatogenesis. (230 aa) |
| | Trim3 | Tripartite motif-containing protein 3; Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Positively regulates motility of microtubule-dependent motor protein KIF21B. (744 aa) |
| | Trim21 | Tripartite motif protein 21 (Predicted), isoform CRA_a. (471 aa) |
| | Sh3rf2 | E3 ubiquitin-protein ligase SH3RF2; Has E3 ubiquitin-protein ligase activity. Acts as an anti- apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro- apoptotic JNK activation. Facilitates TNF-alpha- mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin- mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity (By similarity). (735 aa) |
| | Trim68 | Tripartite motif-containing 68. (490 aa) |
| | Bard1 | BRCA1-associated RING domain protein 1; E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II [...] (768 aa) |
| | Rapsn | Receptor-associated protein of the synapse (Predicted), isoform CRA_a. (412 aa) |
| | Trim27 | Tripartite motif protein 27 (Predicted), isoform CRA_b. (513 aa) |
| | Cblb | E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs [...] (982 aa) |
| | Rnf38 | Ring finger protein 38, isoform CRA_a. (432 aa) |
| | Lonrf3 | LON peptidase N-terminal domain and ring finger 3. (809 aa) |
| | Traf3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (610 aa) |
| | Nfxl1 | Nuclear transcription factor, X-box-binding-like 1. (919 aa) |
| | Rnf4 | E3 ubiquitin-protein ligase RNF4; E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular [...] (196 aa) |
| | Rnf19b | RBR-type E3 ubiquitin transferase. (654 aa) |
| | Rfpl4b | RING-type domain-containing protein. (260 aa) |
| | Pdzrn3 | E3 ubiquitin-protein ligase PDZRN3; E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. (1063 aa) |
| | Amfr | Autocrine motility factor receptor. (630 aa) |
| | LOC102557137 | E3 ubiquitin-protein ligase RNF168-like. (411 aa) |
| | Rbck1 | RanBP-type and C3HC4-type zinc finger-containing protein 1; Component of the LUBAC complex which conjugates linear ('Met- 1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF- induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following p [...] (508 aa) |
| | Mid1 | E3 ubiquitin-protein ligase Midline-1; Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination; Belongs to the TRIM/RBCC family. (667 aa) |
| | Lonrf1 | LON peptidase N-terminal domain and ring finger 1. (833 aa) |
| | Brca1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1817 aa) |
| | Pja2 | E3 ubiquitin-protein ligase Praja-2; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype. (707 aa) |
| | Rspry1 | Ring finger and SPRY domain-containing 1. (578 aa) |
| | Mgrn1 | E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). (554 aa) |
| | Rnf128 | Ring finger protein 128. (428 aa) |
| | Dtx4 | Deltex E3 ubiquitin ligase 4. (513 aa) |
| | Xiap | E3 ubiquitin-protein ligase XIAP; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligas [...] (501 aa) |
| | Rnf11l1 | Ring finger protein 11-like 1. (153 aa) |
| | Zswim2 | Zinc finger, SWIM-type-containing 2. (631 aa) |
| | Rnf212 | Ring finger protein 212. (307 aa) |
| | Trim30c | Tripartite motif-containing 30C. (514 aa) |
| | Trim46 | Tripartite motif-containing protein 46; Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration; Belongs to the TRIM/RBCC family. (561 aa) |
| | Cblc | E3 ubiquitin-protein ligase CBL-C; Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419', has the highest ubiquitin ligase activity among CBL family proteins. In collaboration wi [...] (497 aa) |
| | Mid2 | Midline 2 (Predicted). (705 aa) |
| | Rnf111 | Ring finger protein 111 (Predicted). (987 aa) |
| | Hltf | Helicase-like transcription factor. (1003 aa) |
| | Mdm2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (483 aa) |
| | Rnf144b | RBR-type E3 ubiquitin transferase. (301 aa) |
| | Rbx1 | Ring-box 1. (108 aa) |
| | Unkl | Unk-like zinc finger. (727 aa) |
| | Rnf2 | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] (336 aa) |
| | Rnf114 | E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon produ [...] (229 aa) |
| | Rnf44 | RING finger protein 44. (351 aa) |
| | Trim26 | Tripartite motif-containing protein 26; E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. (545 aa) |
| | Neurl1 | Neuralized-like (Drosophila) (Predicted), isoform CRA_b. (574 aa) |
| | Rffl | E3 ubiquitin-protein ligase rififylin; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signal [...] (334 aa) |
| | Pja1 | Praja ring finger ubiquitin ligase 1. (406 aa) |
| | Rnf139 | Ring finger protein 139. (656 aa) |
| | Zfpl1 | Zinc finger protein-like 1. (310 aa) |
| | Brap | BRCA1-associated protein. (587 aa) |
| | Znrf2 | Zinc and ring finger 2. (245 aa) |
| | Uhrf1 | E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] (829 aa) |
| | Trim42 | Tripartite motif-containing 42. (723 aa) |
| | Dtx1 | Deltex E3 ubiquitin ligase 1. (627 aa) |
| | Rnf130 | E3 ubiquitin-protein ligase RNF130; Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells. (335 aa) |
| | Trim62 | Similar to tripartite motif-containing 62. (475 aa) |
| | Znrf4 | Zinc and ring finger 4. (327 aa) |
| | Rnf187 | E3 ubiquitin-protein ligase RNF187; E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8. (236 aa) |
| | Traf5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa) |
| | Srsf8 | Serine and arginine-rich-splicing factor 8. (214 aa) |
| | Sh3rf3 | SH3 domain-containing ring finger 3. (694 aa) |
| | Rnf14 | RBR-type E3 ubiquitin transferase. (479 aa) |
| | Rnf157 | E3 ubiquitin ligase Rnf157; E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (By similarity). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (By similarity). May act as a scaffold molecule to regulate this process (By similarity). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (By similarity). (682 aa) |
| | Rnf10 | RING finger protein 10; Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination. (803 aa) |
| | Topors | Topoisomerase I binding, arginine/serine-rich (Predicted). (1042 aa) |
| | LOC100912399 | Mitogen-activated protein kinase kinase kinase 1-like. (1302 aa) |
| | Rad18 | RAD18 E3 ubiquitin protein ligase. (494 aa) |
| | Cbl | Cbl proto-oncogene. (914 aa) |
| | Rnf103 | E3 ubiquitin-protein ligase RNF103; Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway. (682 aa) |
| | Vps11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (878 aa) |
| | Trim80 | Tripartite motif protein 80. (642 aa) |
| | Trim17 | E3 ubiquitin-protein ligase TRIM17; May function as a ubiquitin E3 ligase. Belongs to the TRIM/RBCC family. (500 aa) |
| | Rnf13 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. (380 aa) |
| | Trim2 | Tripartite motif-containing protein 2; E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL (By similarity). Plays a neuroprotective function (By similarity). May play a role in neuronal rapid ischemic tolerance. (761 aa) |
| | Zfp598 | Zinc finger protein 598 (Predicted). (902 aa) |
| | Bmi1 | BMI1 proto-oncogene, polycomb ring finger. (324 aa) |
| | Rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa) |
| | Ttc3 | E3 ubiquitin-protein ligase TTC3; E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (By similarity). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (By similarity). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (By similarity). Positively regulates TGFB1-induced epithelial-mesenchymal [...] (2000 aa) |
| | Rnf180 | Ring finger protein 180. (593 aa) |
| | Birc7 | Baculoviral IAP repeat-containing 7. (285 aa) |
| | Trim63 | E3 ubiquitin-protein ligase TRIM63; E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-h [...] (351 aa) |
| | Rnf224 | Ring finger protein 224. (156 aa) |
| | Trim31 | Tripartite motif protein 31 (Predicted). (507 aa) |
| | Nsd1 | Nuclear receptor binding SET domain protein 1 (Predicted), isoform CRA_a. (2381 aa) |
| | Nfx1 | Nuclear transcription factor, X-box-binding 1. (1114 aa) |
| | Lrsam1 | Leucine-rich repeat and sterile alpha motif-containing 1. (728 aa) |
| | Rnf150 | Ring finger protein 150. (437 aa) |
| | Rnf20 | E3 ubiquitin protein ligase; Belongs to the BRE1 family. (973 aa) |
| | Rnf225 | Ring finger protein 225. (330 aa) |
| | Chfr | Checkpoint with forkhead and ring finger domains, isoform CRA_b. (663 aa) |
| | Trim25 | Tripartite motif-containing 25. (643 aa) |
| | Nsmce1 | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] (290 aa) |
| | Anapc11 | Similar to anaphase promoting complex subunit 11 homolog (Predicted), isoform CRA_a. (84 aa) |
| | Arih2 | RBR-type E3 ubiquitin transferase. (492 aa) |
| | Rnf123 | E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS. (1318 aa) |
| | Trim58 | Tripartite motif-containing 58. (485 aa) |
| | Rnf213 | Ring finger protein 213. (5136 aa) |
| | Cop1 | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. (733 aa) |
| | Rnf40 | E3 ubiquitin-protein ligase BRE1B; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradic [...] (1002 aa) |
| | Trim33 | Tripartite motif-containing 33. (1144 aa) |
| | Znrf1 | RCG51260, isoform CRA_a. (227 aa) |
| | Rnf185 | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UB [...] (192 aa) |
| | Rnf220 | RING-type domain-containing protein. (392 aa) |
| | Trim8 | Tripartite motif-containing 8. (551 aa) |
| | Rnf121 | Ring finger protein 121 (Predicted), isoform CRA_c. (327 aa) |
| | Pcgf6 | Polycomb group RING finger protein 6; Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 [...] (351 aa) |
| | Dcst1 | DC-STAMP domain-containing 1. (822 aa) |
| | Syvn1 | Synovial apoptosis inhibitor 1, synoviolin, isoform CRA_b. (612 aa) |
| | Ubox5 | Similar to Rnf37-pending protein. (538 aa) |
| | Rnf24 | Ring finger protein 24 (Predicted), isoform CRA_a. (103 aa) |
| | Neurl3 | E3 ubiquitin-protein ligase NEURL3; E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation. (254 aa) |
| | Marchf3 | E3 ubiquitin-protein ligase MARCHF3; E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. (253 aa) |
| | Vps8 | VPS8 subunit of CORVET complex. (1296 aa) |
| | Nhlrc1 | E3 ubiquitin-protein ligase NHLRC1; E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin- dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen [...] (396 aa) |
| | Trim72 | Tripartite motif-containing protein 72; Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)- depen [...] (477 aa) |
| | Trim28 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa) |
| | Pex10 | Peroxisomal biogenesis factor 10. (324 aa) |
| | Rmnd5a | Required for meiotic nuclear division 5 homolog A. (391 aa) |
| | Rnf222 | Ring finger protein 222. (211 aa) |
| | Trim67 | Tripartite motif-containing 67. (770 aa) |
| | Neurl1b | Neuralized E3 ubiquitin protein ligase 1B. (546 aa) |
| | Msl2 | Male-specific lethal 2-like 1 (Drosophila) (Predicted). (577 aa) |
| | Dtx3l | Deltex E3 ubiquitin ligase 3L. (750 aa) |
| | Trim40 | Tripartite motif-containing protein 40; May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity (By similarity); Belongs to the TRIM/RBCC family. (247 aa) |
| | Rbbp6 | Retinoblastoma binding protein 6, isoform CRA_a. (1789 aa) |
| | Trim50 | E3 ubiquitin-protein ligase TRIM50; E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction; Belongs to the TRIM/RBCC family. (484 aa) |
| | Mex3b | Mex-3 RNA-binding family member B. (576 aa) |
| | Fancl | FA complementation group L. (375 aa) |
| | Lonrf2 | LON peptidase N-terminal domain and ring finger 2. (535 aa) |
| | Rnf122 | RING-type domain-containing protein. (131 aa) |
| | Marchf1 | Membrane associated ring-CH-type finger 1. (254 aa) |
| | Trim11 | E3 ubiquitin-protein ligase TRIM11; E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation [...] (467 aa) |
| | RGD1562871 | Similar to BMI1-like protein. (232 aa) |
| | Phf7 | PHD finger protein 7; May play a role in spermatogenesis. (380 aa) |
| | Trim45 | Tripartite motif protein 45 (Predicted), isoform CRA_b. (579 aa) |
| | Pml | Promyelocytic leukemia. (886 aa) |
| | Rnf32 | RCG56764, isoform CRA_a. (368 aa) |
| | Trim71 | E3 ubiquitin-protein ligase TRIM71; E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (By similarity). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (By similarity). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain pro [...] (855 aa) |
| | Cnot4 | CCR4-NOT transcription complex, subunit 4. (710 aa) |
| | Trim43a | Tripartite motif-containing 43A. (451 aa) |
| | Phrf1 | PHD and RING finger domain-containing protein 1. (1685 aa) |
| | Rnf207 | Ring finger protein 207. (635 aa) |
| | Mex3d | Mex-3 RNA-binding family member D. (662 aa) |
| | Mex3c | Ring finger and KH domain containing 2 (Predicted). (464 aa) |
| | Rnf113a1 | RING finger protein 113A-like. (341 aa) |
