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Col6a1 Col6a1 Col6a2 Col6a2 Adipoq Adipoq C1ql1 C1ql1 Col3a1 Col3a1 Col5a2 Col5a2 C1qtnf2 C1qtnf2 Col1a1 Col1a1 C1qtnf6 C1qtnf6 Mbl2 Mbl2 Col25a1 Col25a1 Col14a1 Col14a1 LOC103693323 LOC103693323 Col13a1 Col13a1 Col2a1 Col2a1 C1qtnf1 C1qtnf1 LOC100909752 LOC100909752 Sftpd Sftpd Col6a5 Col6a5 Col12a1 Col12a1 Col10a1 Col10a1 Col4a6 Col4a6 Col17a1 Col17a1 Col27a1 Col27a1 Emilin1 Emilin1 Colec11 Colec11 Colec10 Colec10 C1qtnf5 C1qtnf5 Col5a1 Col5a1 Fcnb Fcnb Col9a3 Col9a3 Col8a2 Col8a2 Mbl1 Mbl1 Col1a2 Col1a2 C1qb C1qb C1qc C1qc Col19a1 Col19a1 Col15a1 Col15a1 Msr1 Msr1 C1qa C1qa Col9a1 Col9a1 C1qtnf9 C1qtnf9 Col24a1 Col24a1 Scara5 Scara5 Col4a3 Col4a3 Scara3 Scara3 Fcna Fcna C1ql3 C1ql3 C1qtnf3 C1qtnf3 Marco Marco Colq Colq Col5a3 Col5a3 Col7a1 Col7a1 Gldn Gldn Col22a1 Col22a1 Otol1 Otol1 Col4a4 Col4a4 Col6a4 Col6a4 Col18a1 Col18a1 Col11a2 Col11a2 Col20a1 Col20a1 Col9a2 Col9a2 Col6a6 Col6a6 Col4a1 Col4a1 Col4a2 Col4a2 Col8a1 Col8a1 Col4a5 Col4a5 Col16a1 Col16a1 Colec12 Colec12 C1qtnf7 C1qtnf7 Col11a1 Col11a1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Col6a1Collagen type VI alpha 1 chain. (1025 aa)
Col6a2Procollagen, type VI, alpha 2, isoform CRA_a. (1027 aa)
AdipoqAdiponectin, C1Q and collagen domain-containing. (244 aa)
C1ql1Complement component 1, q subcomponent-like 1 (Predicted). (235 aa)
Col3a1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity). (1463 aa)
Col5a2Collagen type V alpha 2 chain. (1494 aa)
C1qtnf2C1q and TNF-related 2. (294 aa)
Col1a1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1453 aa)
C1qtnf6Complement C1q tumor necrosis factor-related protein 6. (263 aa)
Mbl2Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). (244 aa)
Col25a1Collagen type XXV alpha 1 chain. (503 aa)
Col14a1Collagen type XIV alpha 1 chain. (1794 aa)
LOC103693323Collagen alpha-1(XXIII) chain. (532 aa)
Col13a1Similar to alpha 1 type XIII collagen isoform 17, isoform CRA_a. (739 aa)
Col2a1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1419 aa)
C1qtnf1Complement C1q tumor necrosis factor-related protein 1. (332 aa)
LOC100909752Procollagen, type XV, isoform CRA_a. (1345 aa)
SftpdPulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties; Belongs to the SFTPD family. (414 aa)
Col6a5Collagen type VI alpha 5 chain. (2632 aa)
Col12a1Collagen alpha-1(XII) chain; Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. (3143 aa)
Col10a1Collagen type X alpha 1 chain. (680 aa)
Col4a6Collagen type IV alpha 6 chain. (1638 aa)
Col17a1Collagen type XVII alpha 1 chain. (1465 aa)
Col27a1Collagen alpha-1(XXVII) chain; Plays a role during the calcification of cartilage and the transition of cartilage to bone. (1855 aa)
Emilin1Elastin microfibril interfacer 1 (Predicted), isoform CRA_b. (900 aa)
Colec11Collectin sub-family member 11. (271 aa)
Colec10Collectin sub-family member 10 (C-type lectin) (Predicted). (277 aa)
C1qtnf5Complement C1q tumor necrosis factor-related protein 5. (243 aa)
Col5a1Collagen alpha-1(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (By similarity). (1840 aa)
FcnbFicolin-2; May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity); Belongs to the ficolin lectin family. (319 aa)
Col9a3Collagen type IX alpha 3 chain. (680 aa)
Col8a2Collagen type VIII alpha 2 chain. (699 aa)
Mbl1Mannose-binding protein A; Calcium-dependent lectin. Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). (238 aa)
Col1a2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1372 aa)
C1qbComplement C1q subcomponent subunit B; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. (253 aa)
C1qcComplement C1q subcomponent subunit C; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. (248 aa)
Col19a1Collagen type XIX alpha 1 chain. (1129 aa)
Col15a1Collagen alpha-1(XV) chain-like. (1312 aa)
Msr1Macrophage scavenger receptor 1. (509 aa)
C1qaComplement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. (245 aa)
Col9a1Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. (934 aa)
C1qtnf9C1q and TNF-related 9. (367 aa)
Col24a1Collagen type XXIV alpha 1 chain. (1352 aa)
Scara5Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the de [...] (493 aa)
Col4a3Collagen type IV alpha 3 chain. (1671 aa)
Scara3Scavenger receptor class A, member 3 (Predicted). (606 aa)
FcnaFicolin-1; Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen- associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (By similarity). (335 aa)
C1ql3Complement C1q-like 3. (255 aa)
C1qtnf3C1q and TNF-related 3. (319 aa)
MarcoMacrophage receptor with collagenous structure. (470 aa)
ColqAcetylcholinesterase collagenic tail peptide; Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina. (455 aa)
Col5a3Procollagen, type V, alpha 3, isoform CRA_b. (1737 aa)
Col7a1Procollagen, type VII, alpha 1 (Predicted). (2588 aa)
GldnGliomedin shedded ectodomain; Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of [...] (549 aa)
Col22a1Collagen type XXII alpha 1 chain. (1613 aa)
Otol1Otolin 1. (482 aa)
Col4a4Collagen type IV alpha 4 chain. (159 aa)
Col6a4Collagen, type VI, alpha 4. (2113 aa)
Col18a1Procollagen, type XVIII, alpha 1, isoform CRA_a. (1311 aa)
Col11a2Procollagen, type XI, alpha 2 (Mapped). (1650 aa)
Col20a1Collagen type XX alpha 1 chain. (1362 aa)
Col9a2Procollagen, type IX, alpha 2 (Predicted). (688 aa)
Col6a6Collagen type VI alpha 6 chain. (2264 aa)
Col4a1Collagen type IV alpha 1 chain. (1669 aa)
Col4a2Collagen type IV alpha 2 chain. (1645 aa)
Col8a1Collagen type VIII alpha 1 chain. (744 aa)
Col4a5Collagen type IV alpha 5 chain. (1691 aa)
Col16a1Collagen type XVI alpha 1 chain. (1618 aa)
Colec12Collectin-12; Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-oros [...] (742 aa)
C1qtnf7C1q and TNF-related 7. (296 aa)
Col11a1Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. (1804 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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