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| | Plxnb3 | Plexin-B3; Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA- mediated inactivation of RAC1; Belongs to the plexin family. (1902 aa) |
| | LOC365791 | Similar to T-cell activation Rho GTPase-activating protein isoform b. (834 aa) |
| | Arap2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2. (1671 aa) |
| | Arhgap5 | Rho-GTPase-activating protein 5. (1503 aa) |
| | Dlc1 | Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity). (1125 aa) |
| | Arhgap24 | Rho GTPase-activating protein 24; Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamel [...] (657 aa) |
| | Srgap1 | SLIT-ROBO Rho GTPase-activating protein 1. (1085 aa) |
| | Srgap3 | SLIT-ROBO Rho GTPase-activating protein 3. (1099 aa) |
| | Syde1 | Synapse defective Rho GTPase homolog 1. (735 aa) |
| | Plxna2 | Plexin A2. (1894 aa) |
| | Plxnb2 | Plexin B2. (1841 aa) |
| | LOC103689941 | Type II inositol 1,4,5-trisphosphate 5-phosphatase-like. (760 aa) |
| | Arhgap11a | Rho GTPase-activating protein 11A. (994 aa) |
| | Plxnc1 | Plexin C1. (1574 aa) |
| | Arhgap32 | Rho GTPase-activating protein 32. (2101 aa) |
| | Sh3bp1 | SH3 domain-binding protein 1; GTPase activating protein/GAP which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifical [...] (689 aa) |
| | Arhgap25 | Similar to Rho-GTPase-activating protein 25 (Predicted). (648 aa) |
| | Depdc1 | DEP domain-containing 1. (809 aa) |
| | Depdc1b | DEP domain containing 1B (Predicted), isoform CRA_a. (529 aa) |
| | Arhgap18 | Rho GTPase activating protein 18 (Predicted), isoform CRA_a. (665 aa) |
| | Myo9a | Unconventional myosin-IXa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). (2626 aa) |
| | Rasa2 | Ras GTPase-activating protein 2; Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4) and phospholipids. (847 aa) |
| | Arhgap29 | Rho GTPase-activating protein 29; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis (By similarity). (1271 aa) |
| | Arhgap8 | Rho GTPase-activating protein 8. (425 aa) |
| | Plxna4 | Plexin A4. (1893 aa) |
| | Arhgap10 | Rho GTPase-activating protein 10. (786 aa) |
| | Iqgap1 | IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b. (1657 aa) |
| | Arhgap26 | Rho GTPase activating protein 26 (Predicted). (761 aa) |
| | Arhgap35 | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis. Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similar [...] (1513 aa) |
| | Plxna1 | Plexin A1. (1912 aa) |
| | Tagap | T-cell activation GTPase activating protein (Predicted), isoform CRA_b. (714 aa) |
| | Pik3r1 | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (724 aa) |
| | Pik3r2 | Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein- tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating t [...] (722 aa) |
| | Fam13b | Family with sequence similarity 13, member B. (849 aa) |
| | Iqgap3 | IQ motif-containing GTPase-activating protein 3. (1632 aa) |
| | Iqgap2 | IQ motif-containing GTPase-activating protein 2. (1425 aa) |
| | Syde2 | Synapse defective Rho GTPase homolog 2. (1171 aa) |
| | Arhgap23 | Rho GTPase-activating protein 23. (1457 aa) |
| | Plxnd1 | Plexin D1 (Predicted). (1716 aa) |
| | Ralbp1 | RalA-binding protein 1; Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4- dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off [...] (647 aa) |
| | Arhgap33 | Rho GTPase-activating protein 33. (1310 aa) |
| | Arhgap20 | Rho GTPase-activating protein 20; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. (1182 aa) |
| | Arhgap27 | Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1. (869 aa) |
| | Gmip | Gem-interacting protein (Predicted). (969 aa) |
| | Ophn1 | Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function, in hippocampal neurons. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre-synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation. (802 aa) |
| | Arap1 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1443 aa) |
| | Arhgap42 | Rho GTPase-activating protein 42. (826 aa) |
| | Arhgap17 | Rho GTPase-activating protein 17; Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere (By similarity). Participates in the C [...] (858 aa) |
| | Arhgap15 | Rho GTPase-activating protein 15; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction (By similarity). (482 aa) |
| | Syngap1 | Ras/Rap GTPase-activating protein SynGAP; Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. (1308 aa) |
| | Arhgap6 | Rho GTPase-activating protein 6. (737 aa) |
| | Rasa1 | Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21 (By similarity). (996 aa) |
| | Plxnb1 | Plexin B1. (2121 aa) |
| | Arhgap40 | Rho GTPase-activating protein 40. (672 aa) |
| | Nf1 | Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity (By similarity). (2808 aa) |
| | Arhgap39 | Rho GTPase-activating protein 39. (1109 aa) |
| | RGD1306519 | Similar to T-cell activation Rho GTPase-activating protein isoform b. (538 aa) |
| | F1M6I2_RAT | Uncharacterized protein. (796 aa) |
| | LOC691044 | Uncharacterized protein. (713 aa) |
| | Arhgap9 | Rho GTPase-activating protein 9. (639 aa) |
| | D3Z8H5_RAT | Rho-GAP domain-containing protein. (532 aa) |
| | RGD1563562 | Similar to GTPase-activating protein testicular GAP1. (1290 aa) |
| | D3ZRJ5_RAT | Uncharacterized protein. (1297 aa) |
| | Arhgap45 | Histocompatibility (Minor) HA-1 (Predicted), isoform CRA_b. (1116 aa) |
| | Arhgap1 | Rho GTPase-activating protein 1. (439 aa) |
| | Arhgap36 | Rho GTPase-activating protein 36. (588 aa) |
| | Rasal3 | Similar to Ras GTPase-activating protein nGAP (RAS protein activator like 1) (Predicted). (1015 aa) |
| | Chn1 | N-chimaerin; GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. (423 aa) |
| | Arhgap21 | Rho GTPase-activating protein 21. (1955 aa) |
| | Inpp5b | Inositol polyphosphate-5-phosphatase B. (916 aa) |
| | Gapvd1 | GTPase-activating protein and VPS9 domains 1. (1484 aa) |
| | Arhgap28 | Rho GTPase-activating protein 28. (725 aa) |
| | Arhgap19 | Rho GTPase-activating protein 19. (494 aa) |
| | Racgap1 | Rac GTPase-activating protein 1 (Predicted). (626 aa) |
| | Rasal2 | RAS protein activator-like 2. (1279 aa) |
| | Dab2ip | Disabled homolog 2-interacting protein; Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor- mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon [...] (1161 aa) |
| | Plxna3 | Plexin-A3; Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for s [...] (1872 aa) |
| | Abr | Active breakpoint cluster region-related protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GD [...] (842 aa) |
| | Arhgap22 | Rho GTPase-activating protein 22. (700 aa) |
| | Srgap2 | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] (1071 aa) |
| | Arap3 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1536 aa) |
| | Arhgap4 | Rho GTPase activating protein 4, isoform CRA_a. (955 aa) |
| | Rasa3 | Ras GTPase-activating protein 3; Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) (By similarity). (834 aa) |
| | Chn2 | Beta-chimaerin; GTPase-activating protein for p21-rac. (460 aa) |
| | Stard8 | StAR-related lipid transfer domain-containing 8. (1014 aa) |
| | Myo9b | Unconventional myosin-IXb; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (By similarity). Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase acti [...] (2016 aa) |
| | Arhgap12 | Rho GTPase-activating protein 12. (838 aa) |
| | Ocrl | Inositol polyphosphate 5-phosphatase OCRL; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyzes the 4-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5- bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a reg [...] (902 aa) |
| | tGap1 | GTPase-activating protein testicular GAP1. (1387 aa) |
| | Stard13 | StAR-related lipid transfer domain-containing 13. (1112 aa) |
| | Bcr | Breakpoint cluster region protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound t [...] (1062 aa) |
| | Rasal1 | RAS protein activator like 1 (GAP1 like) (Predicted). (801 aa) |
| | Rasa4 | RAS p21 protein activator 4. (803 aa) |
| | Arhgap31 | Cdc42 GTPase-activating protein (Predicted). (1428 aa) |
| | Arhgap44 | Rho GTPase-activating protein 44; GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin- patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contract [...] (797 aa) |
| | Arhgap30 | Similar to RIKEN cDNA 6030405P05 gene (Predicted). (1104 aa) |
