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| | Pcsk7 | Proprotein convertase subtilisin/kexin type 7; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway. (783 aa) |
| | Epha1 | Eph receptor A1 (Predicted). (977 aa) |
| | LOC680835 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin- protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] (1698 aa) |
| | Anapc10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa) |
| | Hectd3 | HECT domain E3 ubiquitin protein ligase 3. (861 aa) |
| | Glb1l | Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family. (646 aa) |
| | Fbxo17 | F-box only protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high- mannose glycoproteins (By similarity). (250 aa) |
| | Xrcc1 | DNA repair protein XRCC1; Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP- ribosyltransferase PARP1 activity. (631 aa) |
| | Cntnap1 | Contactin-associated protein 1; Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells. (1381 aa) |
| | Cpxm1 | Carboxypeptidase X 1 (M14 family) (Predicted). (722 aa) |
| | Zzef1 | Zinc finger ZZ-type and EF-hand domain-containing 1. (2965 aa) |
| | Bin2a | Beta-galactosidase. (637 aa) |
| | Cep104 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip. (922 aa) |
| | Sspo | SCO-spondin; Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity); Belongs to the thrombospondin family. (5141 aa) |
| | Glb1l2 | Beta-galactosidase. (652 aa) |
| | Ephb3 | Eph receptor B3 (Predicted). (1048 aa) |
| | Cntnap5b | Contactin-associated protein like 5-3; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication; Belongs to the neurexin family. (1307 aa) |
| | D4AA49_RAT | Uncharacterized protein. (951 aa) |
| | Rs1 | RCG36316, isoform CRA_a. (224 aa) |
| | Cpxm2 | Carboxypeptidase X (M14 family), member 2. (520 aa) |
| | Epha3 | Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] (984 aa) |
| | LOC304725 | Contactin-associated protein like 5-2; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication; Belongs to the neurexin family. (1292 aa) |
| | Gusb | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (808 aa) |
| | Nrp2 | Neuropilin-2; High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF; Belongs to the neuropilin family. (925 aa) |
| | Trpc2 | Short transient receptor potential channel 2; Thought to form a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Is not activated by intracellular calcium store depletion. (1170 aa) |
| | Epha6 | Ephrin type-A receptor 6; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). (759 aa) |
| | F8 | Coagulation factor VIII; Belongs to the multicopper oxidase family. (2257 aa) |
| | Epha4 | Eph receptor A4. (986 aa) |
| | Epha10 | EPH receptor A10. (1007 aa) |
| | Nr2c2ap | Similar to TR4 orphan receptor associated protein TRA16. (159 aa) |
| | Fbxo44 | F-box protein 44. (255 aa) |
| | Mfge8 | Lactadherin; Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Appears to participate in the O-acetylation of GD3 ganglioside sialic acid. (483 aa) |
| | Cntnap4 | Contactin-associated protein 4. (1241 aa) |
| | Edil3 | EGF-like repeats and discoidin domains 3. (479 aa) |
| | Cntnap5c | Contactin-associated protein like 5-4; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication; Belongs to the neurexin family. (1279 aa) |
| | M0RA85_RAT | Uncharacterized protein. (235 aa) |
| | Ephb4 | RCG21674, isoform CRA_a. (987 aa) |
| | Herc2 | HECT and RLD domain-containing E3 ubiquitin protein ligase 2. (4836 aa) |
| | Dcbld2 | Discoidin, CUB and LCCL domain-containing protein 2. (771 aa) |
| | Nccrp1 | Similar to F-box only protein 6 (F-box/G-domain protein 2) (Predicted). (291 aa) |
| | Ephb2 | Eph receptor B2. (986 aa) |
| | Manba | Beta-mannosidase; Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides; Belongs to the glycosyl hydrolase 2 family. (881 aa) |
| | Hspb11 | Heat shock protein family B (small), member 11. (153 aa) |
| | Txnl1 | Thioredoxin-like protein 1; Active thioredoxin with a redox potential of about -250 mV. (292 aa) |
| | A0A0G2K959_RAT | CULLIN_2 domain-containing protein; Belongs to the cullin family. (382 aa) |
| | Pcsk4 | Proprotein convertase subtilisin/kexin type 4; Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolyt [...] (654 aa) |
| | Ephb6 | Ephrin type-B receptor 6; Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity). (1013 aa) |
| | Aebp1 | Adipocyte enhancer-binding protein 1; As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix (By similarity). May positively regulate MAP- kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. (1127 aa) |
| | Pcsk5 | Proprotein convertase subtilisin/kexin type 5; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors. Belongs to the [...] (915 aa) |
| | Pcsk6 | Proprotein convertase subtilisin/kexin type 6; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues. (934 aa) |
| | Furin | Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. (793 aa) |
| | Pcsk1 | Neuroendocrine convertase 1; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP; Belongs to the peptidase S8 family. Furin subfamily. (752 aa) |
| | Mycbp2 | MYC-binding protein 2. (4538 aa) |
| | Pithd1 | PITH domain-containing 1. (118 aa) |
| | Glb1 | Beta-galactosidase. (647 aa) |
| | Fbxo2 | F-box only protein 2. (296 aa) |
| | Epha2 | Eph receptor A2 (Predicted). (977 aa) |
| | Fbxo6 | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] (284 aa) |
| | Allc | Probable allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals. (413 aa) |
| | Ephb1 | Ephrin type-B receptor 1; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotempora [...] (984 aa) |
| | Glb1l3 | Beta-galactosidase-1-like protein 3; Belongs to the glycosyl hydrolase 35 family. (644 aa) |
| | Epha7 | Ephrin type-A receptor 7; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repel [...] (998 aa) |
| | Hectd1 | HECT domain E3 ubiquitin protein ligase 1. (2610 aa) |
| | Ngly1 | Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins [...] (651 aa) |
| | Pcsk2 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity); Belongs to the peptidase S8 family. Furin subfamily. (637 aa) |
| | Ndufaf1 | NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex, assembly factor 1 (Predicted), isoform CRA_a. (328 aa) |
| | Ntn1 | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involve [...] (575 aa) |
| | Epha5 | Ephrin type-A receptor 5; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in [...] (1039 aa) |
| | Btbd9 | BTB/POZ domain-containing protein 9. (612 aa) |
| | Nrp1 | Neuropilin-1; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins (By similarity). Binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron [...] (922 aa) |
| | Mkln1 | Muskelin; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity). (733 aa) |
| | Ddr1 | Epithelial discoidin domain-containing receptor 1; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Promotes sm [...] (910 aa) |
| | Suco | SUN domain-containing ossification factor; Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity). (1256 aa) |
