6 items (Rattus norvegicus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Fancm	FA complementation group M. (2017 aa)
	Mus81	Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. (551 aa)
	Mgme1	Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (338 aa)
	A0A0G2K855_RAT	ERCC4 domain-containing protein. (914 aa)
	Ercc4	ERCC4 domain-containing protein. (917 aa)
	Ercc1	ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)

Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0G2K855_RAT	Ercc1	ENSRNOP00000074477	ENSRNOP00000024113	ERCC4 domain-containing protein.	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.969
A0A0G2K855_RAT	Ercc4	ENSRNOP00000074477	ENSRNOP00000004563	ERCC4 domain-containing protein.	ERCC4 domain-containing protein.	0.900
A0A0G2K855_RAT	Fancm	ENSRNOP00000074477	ENSRNOP00000074177	ERCC4 domain-containing protein.	FA complementation group M.	0.489
A0A0G2K855_RAT	Mus81	ENSRNOP00000074477	ENSRNOP00000028015	ERCC4 domain-containing protein.	Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family.	0.752
Ercc1	A0A0G2K855_RAT	ENSRNOP00000024113	ENSRNOP00000074477	ERCC excision repair 1, endonuclease non-catalytic subunit.	ERCC4 domain-containing protein.	0.969
Ercc1	Ercc4	ENSRNOP00000024113	ENSRNOP00000004563	ERCC excision repair 1, endonuclease non-catalytic subunit.	ERCC4 domain-containing protein.	0.999
Ercc1	Fancm	ENSRNOP00000024113	ENSRNOP00000074177	ERCC excision repair 1, endonuclease non-catalytic subunit.	FA complementation group M.	0.994
Ercc1	Mus81	ENSRNOP00000024113	ENSRNOP00000028015	ERCC excision repair 1, endonuclease non-catalytic subunit.	Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family.	0.957
Ercc4	A0A0G2K855_RAT	ENSRNOP00000004563	ENSRNOP00000074477	ERCC4 domain-containing protein.	ERCC4 domain-containing protein.	0.900
Ercc4	Ercc1	ENSRNOP00000004563	ENSRNOP00000024113	ERCC4 domain-containing protein.	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.999
Ercc4	Fancm	ENSRNOP00000004563	ENSRNOP00000074177	ERCC4 domain-containing protein.	FA complementation group M.	0.799
Ercc4	Mus81	ENSRNOP00000004563	ENSRNOP00000028015	ERCC4 domain-containing protein.	Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family.	0.942
Fancm	A0A0G2K855_RAT	ENSRNOP00000074177	ENSRNOP00000074477	FA complementation group M.	ERCC4 domain-containing protein.	0.489
Fancm	Ercc1	ENSRNOP00000074177	ENSRNOP00000024113	FA complementation group M.	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.994
Fancm	Ercc4	ENSRNOP00000074177	ENSRNOP00000004563	FA complementation group M.	ERCC4 domain-containing protein.	0.799
Fancm	Mus81	ENSRNOP00000074177	ENSRNOP00000028015	FA complementation group M.	Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family.	0.997
Mus81	A0A0G2K855_RAT	ENSRNOP00000028015	ENSRNOP00000074477	Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family.	ERCC4 domain-containing protein.	0.752
Mus81	Ercc1	ENSRNOP00000028015	ENSRNOP00000024113	Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family.	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.957
Mus81	Ercc4	ENSRNOP00000028015	ENSRNOP00000004563	Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family.	ERCC4 domain-containing protein.	0.942
Mus81	Fancm	ENSRNOP00000028015	ENSRNOP00000074177	Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family.	FA complementation group M.	0.997

Server load: low (18%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About