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Ube2g1 Ube2g1 Ube2j2 Ube2j2 Cdc34 Cdc34 Rwdd4 Rwdd4 Ube2n Ube2n Birc6 Birc6 LOC100125386 LOC100125386 Rnf14 Rnf14 M0R6B6_RAT M0R6B6_RAT Ube2h Ube2h Impact Impact LOC103694506 LOC103694506 Rwdd1 Rwdd1 Ube2v2 Ube2v2 Ube2d3 Ube2d3 Ube2a Ube2a Aktip Aktip Ube2z Ube2z Ube2l3 Ube2l3 Uevld Uevld Ube2e2 Ube2e2 D3ZL88_RAT D3ZL88_RAT Ube2ql1 Ube2ql1 Rwdd3 Rwdd3 Wdr59 Wdr59 Ube2d4 Ube2d4 Rwdd2b Rwdd2b Ube2l6 Ube2l6 F1M227_RAT F1M227_RAT Fancl Fancl Ube2v1 Ube2v1 Ube2m Ube2m Ube2k Ube2k Ube2u Ube2u Ube2q1 Ube2q1 Ube2f Ube2f Ube2i Ube2i Ube2s Ube2s Rnf25 Rnf25 Ube2c Ube2c Ube2q2 Ube2q2 Tsg101 Tsg101 Ube2b Ube2b Vps37a Vps37a Ube2r2 Ube2r2 Ube2o Ube2o Rwdd2a Rwdd2a Ube2e1 Ube2e1 Eif2ak4 Eif2ak4 Ube2t Ube2t Ube2e3 Ube2e3 Ufc1 Ufc1 Ube2g2 Ube2g2 Ube2d1 Ube2d1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Ube2g1Ubiquitin-conjugating enzyme E2 G1, N-terminally processed; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
Ube2j2Similar to Ubc6p homolog, isoform CRA_a. (271 aa)
Cdc34RCG29282, isoform CRA_b; Belongs to the ubiquitin-conjugating enzyme family. (235 aa)
Rwdd4RWD domain-containing protein 4. (188 aa)
Ube2nUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
Birc6Baculoviral IAP repeat-containing 6. (3993 aa)
LOC100125386LOC100125386 protein. (56 aa)
Rnf14RBR-type E3 ubiquitin transferase. (479 aa)
M0R6B6_RATUBIQUITIN_CONJUGAT_2 domain-containing protein. (150 aa)
Ube2hUbiquitin-conjugating enzyme E2H; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
ImpactProtein IMPACT; Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 ac [...] (317 aa)
LOC103694506Ubiquitin-conjugating enzyme E2 W; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation [...] (146 aa)
Rwdd1RWD domain-containing protein 1; Protects DRG2 from proteolytic degradation; Belongs to the RWDD1/GIR2 family. (243 aa)
Ube2v2Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage; Belongs to the ubiquitin-conjugating enzym [...] (145 aa)
Ube2d3Ubiquitin-conjugating enzyme E2 D3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed [...] (147 aa)
Ube2aUbiquitin-conjugating enzyme E2A, RAD6 homolog (S. cerevisiae); Belongs to the ubiquitin-conjugating enzyme family. (162 aa)
AktipAKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity). (292 aa)
Ube2zUbiquitin-conjugating enzyme E2 Z; Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation; Belongs to the ubiquitin-conjugating enzyme family. (356 aa)
Ube2l3Ubiquitin-conjugating enzyme E2L 3 (Predicted). (166 aa)
UevldUEV and lactate/malate dehyrogenase domains. (470 aa)
Ube2e2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (126 aa)
D3ZL88_RATUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (150 aa)
Ube2ql1Ubiquitin-conjugating enzyme E2Q family-like 1. (304 aa)
Rwdd3RWD domain-containing protein 3; Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Negatively regula [...] (267 aa)
Wdr59WD repeat domain 59. (933 aa)
Ube2d4Ubiquitin-conjugating enzyme E2 D2B; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection Plays a role i [...] (147 aa)
Rwdd2bRWD domain-containing protein. (290 aa)
Ube2l6Ubiquitin/ISG15-conjugating enzyme E2 L6; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. (153 aa)
F1M227_RATUBIQUITIN_CONJUGAT_2 domain-containing protein. (139 aa)
FanclFA complementation group L. (375 aa)
Ube2v1Ubiquitin-conjugating enzyme E2 V1. (147 aa)
Ube2mUbiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
Ube2kHuntingtin interacting protein 2 (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
Ube2uUbiquitin-conjugating enzyme E2 U. (337 aa)
Ube2q1Ubiquitin-conjugating enzyme E2Q (Putative) (Predicted), isoform CRA_a. (422 aa)
Ube2fNEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. (185 aa)
Ube2iSUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451 (By similarity). Can catalyze the formation of poly-SUMO chains (By similarity). Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386' (By similarity). Mediates sumoylation of ERCC6 which is essential for its transcription-coupled [...] (158 aa)
Ube2sUbiquitin-conjugating enzyme E2 S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiqui [...] (223 aa)
Rnf25Ring finger protein 25. (454 aa)
Ube2cUbiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
Ube2q2Ubiquitin-conjugating enzyme E2Q family member 2. (376 aa)
Tsg101Tumor susceptibility gene 101 protein; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the [...] (391 aa)
Ube2bUbiquitin-conjugating enzyme E2 B; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys- 120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-l [...] (180 aa)
Vps37aSimilar to DNA segment, Chr 8, ERATO Doi 531, expressed, isoform CRA_c. (398 aa)
Ube2r2Ubiquitin-conjugating enzyme E2R 2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
Ube2oUbiquitin-conjugating enzyme E2O. (1138 aa)
Rwdd2aRWD domain-containing protein. (292 aa)
Ube2e1Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (173 aa)
Eif2ak4eIF-2-alpha kinase GCN2; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2- alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability. Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a transla [...] (1649 aa)
Ube2tUbiquitin-conjugating enzyme E2T (Putative) (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family. (204 aa)
Ube2e3Ubiquitin-conjugating enzyme E2E 3; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
Ufc1Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage; Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily. (167 aa)
Ube2g2Ubiquitin-conjugating enzyme E2G 2 (Predicted), isoform CRA_b; Belongs to the ubiquitin-conjugating enzyme family. (165 aa)
Ube2d1Ubiquitin-conjugating enzyme E2 D1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Mediates the selective degradation of short- lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4 (By [...] (147 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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