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Zfyve21 Zfyve21 Wdfy3 Wdfy3 Rph3al Rph3al Fgd2 Fgd2 Zfyve9 Zfyve9 Rufy2 Rufy2 Plekhf2 Plekhf2 Ankfy1 Ankfy1 Pikfyve Pikfyve Plekhf1 Plekhf1 Fgd5 Fgd5 Zfyve28 Zfyve28 Zfyve19 Zfyve19 Rbsn Rbsn Zfyve1 Zfyve1 Mtmr4 Mtmr4 Fyco1 Fyco1 Rufy1 Rufy1 Rph3a Rph3a Zfyve26 Zfyve26 Rims2 Rims2 Zfyve27 Zfyve27 Hgs Hgs Rims1 Rims1 Fgd6 Fgd6 Mtmr3 Mtmr3 Wdfy2 Wdfy2 Eea1 Eea1 Fgd3 Fgd3 Wdfy1 Wdfy1 Zfyve16 Zfyve16 Fgd4 Fgd4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Zfyve21Zinc finger FYVE domain-containing protein 21; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta- 1/ITGB1 cell surface expression (By similarity). (252 aa)
Wdfy3WD repeat and FYVE domain-containing 3. (3506 aa)
Rph3alRab effector Noc2; Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A. Acts as a potential RAB3B effector protein in epithelial cells. (302 aa)
Fgd2FYVE, RhoGEF and PH domain-containing 2. (655 aa)
Zfyve9Zinc finger FYVE domain-containing protein. (1398 aa)
Rufy2RUN and FYVE domain-containing protein 2-like. (605 aa)
Plekhf2Pleckstrin homology domain containing, family F (With FYVE domain) member 2 (Predicted). (249 aa)
Ankfy1Ankyrin repeat and FYVE domain-containing 1. (1169 aa)
PikfyvePhosphoinositide kinase, FYVE-type zinc finger-containing. (2109 aa)
Plekhf1Pleckstrin homology domain-containing family F member 1; May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity). (279 aa)
Fgd5FYVE, RhoGEF and PH domain-containing 5. (1519 aa)
Zfyve28Zinc finger, FYVE domain containing 28 (Predicted). (905 aa)
Zfyve19Similar to Zinc finger, FYVE domain containing 19. (386 aa)
RbsnZinc finger, FYVE domain containing 20 (Predicted). (783 aa)
Zfyve1Zinc finger, FYVE domain containing 1 (Predicted), isoform CRA_a. (777 aa)
Mtmr4Myotubularin-related protein 4. (1191 aa)
Fyco1FYVE and coiled-coil domain containing 1 (Predicted). (1451 aa)
Rufy1RUN and FYVE domain-containing 1. (711 aa)
Rph3aRabphilin-3A; Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone. (684 aa)
Zfyve26Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity); Belongs to the ZFYVE26 family. (2542 aa)
Rims2Regulating synaptic membrane exocytosis protein 2; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity). (1555 aa)
Zfyve27Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] (411 aa)
HgsHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (914 aa)
Rims1Regulating synaptic membrane exocytosis protein 1; Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Plays a role in dendrite formation by melanocytes. (1614 aa)
Fgd6Similar to FYVE, RhoGEF and PH domain containing 6 (Predicted). (1406 aa)
Mtmr3Myotubularin-related protein 3; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3- phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity). (1207 aa)
Wdfy2WD repeat and FYVE domain-containing 2. (400 aa)
Eea1Early endosome antigen 1. (1449 aa)
Fgd3FYVE, RhoGEF and PH domain containing 3 (Predicted), isoform CRA_a. (733 aa)
Wdfy1WD repeat and FYVE domain-containing 1. (410 aa)
Zfyve16Zinc finger FYVE-type-containing 16. (1547 aa)
Fgd4FYVE, RhoGEF and PH domain-containing protein 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8. (764 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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