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| | Hoxc4 | Homeobox protein Hox-C4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (264 aa) |
| | Alx4 | Aristaless 4 (Predicted). (399 aa) |
| | Pbx2 | Pre-B-cell leukemia transcription factor 2. (430 aa) |
| | Pou1f1 | Pituitary-specific positive transcription factor 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. Belongs to the POU transcription factor family. Class-1 subfamily. (291 aa) |
| | Gsx1 | Genomic screened homeo box 1 (Predicted). (261 aa) |
| | Uncx | Homeobox protein unc-4 homolog; Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity). (530 aa) |
| | Lhx5 | LIM/homeobox protein Lhx5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system. (402 aa) |
| | Hoxd1 | Homeo box D1 (Predicted). (328 aa) |
| | Hoxd4 | Homeo box D4 (Predicted), isoform CRA_a. (251 aa) |
| | Hoxd10 | Homeo box D10. (410 aa) |
| | Hoxd13 | Homeo box D13 (Predicted). (331 aa) |
| | Evx2 | Even-skipped homeobox 2. (373 aa) |
| | Barhl2 | BarH-like 2 homeobox protein; Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up- regulate NGN2, thereby regulating distinct patterns of neuronal differentiation; Belongs to the BAR homeobox family. (384 aa) |
| | Nkx6-1 | Homeobox protein Nkx-6.1; Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity). (365 aa) |
| | Gsx2 | Genomic screened homeo box 2 protein. (305 aa) |
| | Hlx | H2.0-like homeobox protein; Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity); Belongs to the H2.0 homeobox family. (476 aa) |
| | Pou3f4 | POU domain, class 3, transcription factor 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain; Belongs to the POU transcription factor family. Class-3 subfamily. (361 aa) |
| | Lhx1 | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa) |
| | Cdx4 | Caudal type homeo box 4 (Predicted). (288 aa) |
| | Mixl1 | Mix paired-like homeobox 1. (231 aa) |
| | Prop1 | PROP paired-like homeobox 1. (223 aa) |
| | Prrx1 | Paired mesoderm homeobox protein 1; Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). (245 aa) |
| | Dlx3 | Distal-less homeobox 3 (Predicted). (287 aa) |
| | Dlx4 | Distal-less homeobox 4 (Predicted). (238 aa) |
| | Alx1 | ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Early on in development, it plays a role in forebrain mesenchyme survival (By similarity). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity). Belongs to the paired homeobox family. (326 aa) |
| | Lmx1a | LIM homeobox transcription factor 1 alpha. (382 aa) |
| | Tlx3 | Similar to HOX11L2 (Predicted), isoform CRA_a. (291 aa) |
| | Hoxa1 | Homeobox protein Hox-A1; Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (By similarity). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A [...] (334 aa) |
| | Hoxa2 | Homeobox protein Hox-A2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Proboscipedia subfamily. (372 aa) |
| | Hoxa3 | Homeobox protein Hox-A3. (444 aa) |
| | LOC103692127 | Homeobox protein Hox-A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity); Belongs to the Antp homeobox family. (270 aa) |
| | Meox2 | Homeobox protein MOX-2; Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle. (303 aa) |
| | Lhx6 | LIM homeobox 6. (392 aa) |
| | En2 | Homeobox protein engrailed-like. (323 aa) |
| | Pou3f2 | POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL [...] (445 aa) |
| | Dbx2 | Developing brain homeobox 2. (377 aa) |
| | Lhx8 | LIM homeobox 8. (336 aa) |
| | Hoxb13 | Homeo box B13 (Predicted). (286 aa) |
| | Hoxb9 | Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa) |
| | Hoxb8 | Homeobox protein Hox-B8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (243 aa) |
| | LOC100909443 | Homeobox A11. (313 aa) |
| | Hoxb6 | Similar to homeotic protein Hox 2.2-mouse (Predicted). (224 aa) |
| | Pax4 | Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity); Belongs to the paired homeobox family. (349 aa) |
| | Hoxb5 | Similar to homeotic protein Hox B5-mouse (Predicted). (269 aa) |
| | Hoxb4 | Similar to homeotic protein Hox B4-mouse (Predicted). (250 aa) |
| | Hoxb3 | Hoxb3 protein. (428 aa) |
| | Hoxb2 | Homeo box B2 (Predicted). (355 aa) |
| | Barx2 | BARX homeobox 2. (290 aa) |
| | Hoxb1 | Homeo box B1 (Predicted), isoform CRA_a. (297 aa) |
| | Nkx2-1 | Homeobox protein Nkx-2.1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circad [...] (372 aa) |
| | Nkx2-8 | NK2 transcription factor related, locus 9 (Drosophila) (Predicted). (234 aa) |
| | Zfhx4 | Zinc finger homeobox 4. (3593 aa) |
| | Vax1 | Ventral anterior homeobox 1; Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity); Belongs to the EMX homeobox family. (336 aa) |
| | Pou2f3 | POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Activates cytokeratin 10 (K10) gene expression. May serve a regulatory function with respect to epidermal development. Isoform 2 inhibits transactivation by OCT-1; Belongs to the POU transcription factor family. Class-2 subfamily. (430 aa) |
| | Hmx1 | H6 homeo box 1 (Predicted), isoform CRA_b. (333 aa) |
| | Emx2 | Similar to empty spiracles-like protein 2 (Predicted), isoform CRA_a. (253 aa) |
| | Otp | Orthopedia homolog (Drosophila), isoform CRA_a. (325 aa) |
| | Gsc | Goosecoid homeobox. (256 aa) |
| | Lhx9 | LIM/homeobox protein Lhx9; Involved in gonadal development. (388 aa) |
| | Lhx2 | LIM/homeobox protein Lhx2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity). (427 aa) |
| | Irx6 | Similar to iroquois homeobox protein 6 (Predicted). (443 aa) |
| | Dlx5 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL an [...] (289 aa) |
| | Irx5 | Iroquois homeobox protein 5. (484 aa) |
| | Pitx1 | Pituitary homeobox 1; Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. (315 aa) |
| | Irx3 | Iroquois related homeobox 3 (Drosophila) (Predicted), isoform CRA_b. (326 aa) |
| | Vsx2 | Ceh-10 homeo domain containing homolog (C. elegans), isoform CRA_a. (361 aa) |
| | Pou4f2 | POU domain, class 4, transcription factor 2; Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells. Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner. Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooper [...] (412 aa) |
| | Shox2 | Short stature homeobox protein 2; May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. (233 aa) |
| | Nkx2-4 | NK2 homeobox 4. (353 aa) |
| | Irx4 | Iroquois related homeobox 4 (Drosophila) (Predicted). (515 aa) |
| | Irx2 | Iroquois homeobox 2. (474 aa) |
| | Isl1 | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (By similarity). Binds to insulin gene enhancer sequence [...] (349 aa) |
| | Nkx2-2 | NK2 homeobox 2. (273 aa) |
| | Barhl1 | BarH-like 1 homeobox protein. (327 aa) |
| | Gbx1 | Gastrulation brain homeobox 1. (425 aa) |
| | Vax2 | Ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina; Belongs to the EMX homeobox family. (292 aa) |
| | Pax3 | Paired box 3. (484 aa) |
| | Crx | Cone-rod homeobox protein. (299 aa) |
| | Hesx1 | Similar to anterior-restricted homeobox protein (Predicted). (185 aa) |
| | Zfhx3 | Zinc finger homeobox 3. (3730 aa) |
| | Dbx1 | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity). (335 aa) |
| | Nkx3-1 | NK-3 transcription factor, locus 1 (Drosophila). (238 aa) |
| | Emx1 | Similar to empty spiracles homolog 1 (Predicted). (290 aa) |
| | Isl2 | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. (359 aa) |
| | Hoxc12 | Homeo box C12 (Predicted). (280 aa) |
| | Hoxc11 | Homeobox C11. (304 aa) |
| | Hoxc10 | Homeo box C10, isoform CRA_b. (342 aa) |
| | Tlx1 | Similar to transcription factor (Predicted). (333 aa) |
| | Lbx1 | Transcription factor LBX1; Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord. (285 aa) |
| | Hoxc9 | Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa) |
| | Hoxc6 | Homeo box C6. (235 aa) |
| | Hoxc5 | Homeo box C5 (Predicted). (222 aa) |
| | Rax | Retinal homeobox protein Rx; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE- 1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity). (342 aa) |
| | Barx1 | BarH-like homeobox 1 (Predicted). (254 aa) |
| | Nkx1-2 | RCG47496, isoform CRA_a. (305 aa) |
| | Lmx1b | LIM homeobox transcription factor 1 beta. (395 aa) |
| | Nkx6-3 | NK6 homeobox 3. (262 aa) |
| | Alx3 | ALX homeobox 3. (254 aa) |
| | Msx2 | Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity). (267 aa) |
| | Pou4f3 | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear. (338 aa) |
| | Pax7 | Paired box 7. (503 aa) |
| | Mkx | Mohawk homeobox. (315 aa) |
| | Pitx3 | Pituitary homeobox 3; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep pro [...] (302 aa) |
| | Gbx2 | Gastrulation brain homeobox 2. (348 aa) |
| | Phox2a | Paired mesoderm homeobox protein 2A; May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype; Belongs to the paired homeobox family. (279 aa) |
| | Drgx | Dorsal root ganglia homeobox protein; Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain. (263 aa) |
| | Hmx3 | Similar to homeodomain protein (Predicted). (356 aa) |
| | Hmx2 | Similar to Hmx2 protein (Predicted), isoform CRA_b. (273 aa) |
| | Nkx2-5 | Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4. Binds to the core DNA motif of NPPA promoter. It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B. It is required for spleen development; Belongs to the NK-2 homeobox family. (319 aa) |
| | Meox1 | Mesenchyme homeobox 1 (Predicted). (253 aa) |
| | Zfhx2 | Zinc finger homeobox 2. (2558 aa) |
| | Pbx3 | Pre B-cell leukemia transcription factor 3 (Predicted). (434 aa) |
| | Bsx | Brain-specific homeobox. (232 aa) |
| | Hoxb7 | Homeobox protein Hox-B7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (219 aa) |
| | Hoxc13 | Homeobox C13. (328 aa) |
| | Nkx2-6 | NK2 homeobox 6. (213 aa) |
| | Hoxd3 | Homeobox protein Hox-D3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (432 aa) |
| | Rhox13 | Rhox homeobox family member 13. (233 aa) |
| | Hoxc8 | Homeobox protein Hox-C8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (242 aa) |
| | Hoxa4 | Homeobox protein Hox-A4. (285 aa) |
| | Six1 | Sine oculis homeobox homolog 1 (Drosophila). (284 aa) |
| | Hoxa10 | Homeobox A10. (413 aa) |
| | Irx1 | Iroquois homeobox 1. (480 aa) |
| | Obox2 | Oocyte-specific homeobox 2. (311 aa) |
| | Lhx3 | RCG45383, isoform CRA_b. (402 aa) |
| | Pou2f1 | POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). (768 aa) |
| | Cdx2 | Caudal type homeo box 2. (310 aa) |
| | Pitx2 | Pituitary homeobox 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach (By similarity). (324 aa) |
| | Gsc2 | Goosecoid-like (Predicted). (214 aa) |
| | LOC100361016 | Oocyte-specific homeobox 5-like. (288 aa) |
| | Six4 | Sine oculis-related homeobox 4 homolog (Drosophila) (Predicted). (705 aa) |
| | Nkx2-3 | NK2 transcription factor related, locus 3 (Drosophila) (Predicted). (362 aa) |
| | Nkx6-2 | NK6 transcription factor related, locus 2 (Drosophila) (Predicted). (277 aa) |
| | Dmbx1 | Diencephalon/mesencephalon homeobox 1 (Predicted), isoform CRA_a. (376 aa) |
| | Cux1 | Homeobox protein cut-like 1; Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity). Binds to the TH enhancer; may require the basic helix-loop-helix protein T [...] (1504 aa) |
| | Isx | Intestine-specific homeobox. (242 aa) |
| | Vsx1 | Visual system homeobox 1. (369 aa) |
| | Hoxd9 | Homeobox protein Hox-D9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (332 aa) |
| | Hoxd12 | Homeo box D12. (268 aa) |
| | Lhx4 | LIM homeobox 4. (389 aa) |
| | Nanog | Nanog homeobox. (312 aa) |
| | Evx1 | Even-skipped homeobox 1. (407 aa) |
| | LOC103692128 | Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (271 aa) |
| | Nkx1-1 | NK1 homeobox 1. (443 aa) |
| | Mnx1 | Motor neuron and pancreas homeobox 1. (402 aa) |
| | Pou5f1 | POU domain protein. (352 aa) |
| | Hoxa7-2 | Homeobox protein Hox-A7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (229 aa) |
| | M0R8Z6_RAT | Homeobox domain-containing protein. (275 aa) |
| | Pdx1 | Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa) |
| | Msx3 | RCG48500, isoform CRA_b. (204 aa) |
| | En1 | Homeobox protein engrailed-like. (399 aa) |
| | Tlx2-2 | T-cell leukemia homeobox 2. (284 aa) |
| | LOC100909604 | Homeobox protein Hox-A6-like. (233 aa) |
| | Prrx2 | Paired-related homeobox 2. (247 aa) |
| | Phox2b | Paired-like homeobox 2b. (307 aa) |
| | Pax6 | Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity). Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains; Belongs to the paired homeobox family. (433 aa) |
| | Nkx3-2 | NK3 homeobox 2. (320 aa) |
| | Cdx1 | Homeobox protein CDX-1; Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA. (271 aa) |
| | Otx1 | Homeobox protein OTX1; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC- 3' (By similarity). May play a role in the specification or differentiation of neurons in the deep layers of the cerebral cortex, and also in cerebellar regionalization during early development. Belongs to the paired homeobox family. Bicoid subfamily. (324 aa) |
| | Pou2f2 | POU domain protein. (479 aa) |
| | Pou3f3 | POU domain, class 3, transcription factor 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity). (487 aa) |
| | Six5 | SIX homeobox 5. (720 aa) |
| | Pou4f1 | POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N- terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects ne [...] (417 aa) |
| | LOC691325 | Homeobox domain-containing protein. (344 aa) |
| | Arx | Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (By similarity). Belongs to the paired homeobox family. Bicoid subfamily. (565 aa) |
| | LOC100911668-2 | Homeobox A10. (94 aa) |
