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| | Tesc | Tescalcin. (214 aa) |
| | Rasgrp3 | RAS guanyl-releasing protein 3. (691 aa) |
| | Ppef2 | Serine/threonine-protein phosphatase with EF-hands. (754 aa) |
| | Macf1 | Microtubule-actin cross-linking factor 1; F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesion [...] (7384 aa) |
| | Usp32 | Ubiquitin-specific peptidase 32; Belongs to the peptidase C19 family. (1640 aa) |
| | Cabp7 | Calcium-binding protein 7; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. (215 aa) |
| | Capsl | Calcyphosine-like (Predicted). (208 aa) |
| | Lpcat2b | Lysophosphatidylcholine acyltransferase 2B; Probable acetyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (517 aa) |
| | Rhot1 | Ras homolog family member T1. (752 aa) |
| | LOC108348197 | Calpain small subunit 1-like. (165 aa) |
| | Cetn2 | Centrin 2, isoform CRA_a. (172 aa) |
| | Sptan1 | Spectrin alpha chain, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Belongs to the spectrin family. (2498 aa) |
| | Reps2 | RALBP1 associated Eps domain containing protein 2. (574 aa) |
| | Cib2 | Calcium and integrin-binding family member 2; Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release. May be involved in the mechanotransduction process. (187 aa) |
| | Micu1 | Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. [...] (481 aa) |
| | Kcnip3 | Calsenilin; Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation (By similarity); Belongs to the recoverin family. (256 aa) |
| | Smoc2 | SPARC-related modular calcium-binding 2. (457 aa) |
| | Rcn3 | Reticulocalbin-3; Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (By similarity). Required for the proper biosynthesis and transport of pulmonary surfactant- associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity [...] (337 aa) |
| | Lcp1 | Lymphocyte cytosolic protein 1. (645 aa) |
| | Reps1 | RALBP1-associated Eps domain-containing 1. (744 aa) |
| | Dnah7 | Dynein heavy chain 7, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family. (3697 aa) |
| | Cracr2a | Calcium release activated channel regulator 2A. (310 aa) |
| | Caps2 | Calcyphosine 2. (549 aa) |
| | Mcfd2 | Multiple coagulation factor deficiency protein 2 homolog; The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. (145 aa) |
| | Plcg1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). (1290 aa) |
| | Efcab11 | EF-hand calcium-binding domain-containing protein 11. (162 aa) |
| | Ppp2r3c | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B- cells. (453 aa) |
| | Actn1 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (914 aa) |
| | Ehd3 | EH domain-containing protein 3; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes. Binding to phosphatidic acid induces its membrane tubulation activity. Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology. Involved in the recycling of internalized D1 dopamine recept [...] (572 aa) |
| | Fstl5 | Follistatin-like 5. (847 aa) |
| | Plch1 | Phosphoinositide phospholipase C. (1648 aa) |
| | M0RCJ6_RAT | Uncharacterized protein; Belongs to the calmodulin family. (147 aa) |
| | Efcab1 | Similar to EF hand calcium binding domain 1. (212 aa) |
| | Hpcal4 | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. (191 aa) |
| | Sri | LOC683667 protein. (198 aa) |
| | Ppp2r3b | Protein phosphatase 2, regulatory subunit B'', beta. (552 aa) |
| | Itsn2 | Intersectin 2. (1716 aa) |
| | Cabp2 | Similar to L-CaBP2 (Predicted), isoform CRA_a. (203 aa) |
| | LOC100912380 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (243 aa) |
| | Slc25a23 | Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (467 aa) |
| | LOC100912538 | Centrin 3. (167 aa) |
| | Ncald | Neurocalcin-delta; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). Belongs to the recoverin family. (193 aa) |
| | Cetn4 | Centrin 4. (167 aa) |
| | Ninl | Ninein-like. (1393 aa) |
| | LOC500007 | Similar to EF hand calcium-binding domain 1. (217 aa) |
| | Fstl4 | Follistatin-like 4 (Predicted). (832 aa) |
| | Capn11 | Calpain 11; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family. (715 aa) |
| | Eps15 | Epidermal growth factor receptor pathway substrate 15. (897 aa) |
| | Dgkb | Diacylglycerol kinase beta; Exhibits high phosphorylation activity for long-chain diacylglycerols. (802 aa) |
| | Ppp3r1 | Calcineurin subunit B type 1; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. (170 aa) |
| | Pvalb | Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; Belongs to the parvalbumin family. (110 aa) |
| | Pls3 | Plastin-3; Actin-bundling protein. (630 aa) |
| | Ppef1 | Serine/threonine-protein phosphatase with EF-hands 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development (By similarity). Belongs to the PPP phosphatase family. (625 aa) |
| | Rasef | RAS and EF hand domain-containing. (709 aa) |
| | Chp1 | Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane- type Na(+)/H(+) ex [...] (195 aa) |
| | Ehd1 | EH domain-containing protein 1; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (By similarity). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (By similarity). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to ax [...] (534 aa) |
| | Myl10 | Myosin light chain 10. (147 aa) |
| | Cib1 | Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] (191 aa) |
| | Capn2 | Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs; Belongs to the peptidase C2 family. (700 aa) |
| | Myl12b | Myosin regulatory light chain 12B; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. (172 aa) |
| | Duox1 | Dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. (1551 aa) |
| | Itsn1 | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] (1713 aa) |
| | S100a7a | S100 calcium-binding protein A7A. (108 aa) |
| | Gpd2 | Glycerol-3-phosphate dehydrogenase, mitochondrial. (726 aa) |
| | Dst | Dystonin. (7512 aa) |
| | Calml3 | Calmodulin-like protein 3; May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates (By similarity). (149 aa) |
| | Plcd1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. (756 aa) |
| | Kcnip4 | Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Belongs to the recoverin family. (230 aa) |
| | F1LYQ0_RAT | Protein S100; Belongs to the S-100 family. (103 aa) |
| | Ocm2 | Oncomodulin; Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions; Belongs to the parvalbumin family. (109 aa) |
| | Calm2 | Calmodulin-2; Belongs to the calmodulin family. (149 aa) |
| | Kcnip2 | Kv channel-interacting protein 2; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Essential for the expression of I(To) currents in the heart (By similarity). Required for normal protein levels of KCND2 in the heart ventricle (By similarity). Belongs to the recoverin family. (270 aa) |
| | Myl2 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] (160 aa) |
| | Dgka | Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. (727 aa) |
| | Efcab5 | EF-hand calcium-binding domain 5. (1350 aa) |
| | Slc25a12 | Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (655 aa) |
| | Slc25a54 | Solute carrier family 25, member 54; Belongs to the mitochondrial carrier (TC 2.A.29) family. (473 aa) |
| | Rasgrp2 | RAS guanyl-releasing protein 2; Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. (608 aa) |
| | Capn1 | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (713 aa) |
| | Nucb1 | Nucleobindin-1; Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins). (459 aa) |
| | Actn4 | Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcri [...] (911 aa) |
| | Slc25a24 | Solute carrier family 25 member 24; Belongs to the mitochondrial carrier (TC 2.A.29) family. (475 aa) |
| | Nucb2 | Nucleobindin-2; Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3. (420 aa) |
| | Capn12 | Calpain 12; Belongs to the peptidase C2 family. (719 aa) |
| | P4htm | Similar to prolyl-4-hydroxylase-alpha NE2 CG9720-PA (Predicted). (503 aa) |
| | Myl9 | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. (172 aa) |
| | Sdf4 | 45 kDa calcium-binding protein; A membrane-associated isoform may be involved in the exocytosis of zymogens by pancreatic acini. May regulate calcium- dependent activities in the endoplasmic reticulum lumen or post-ER compartment. (382 aa) |
| | Rhot2 | Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (622 aa) |
| | Tescl | Similar to RIKEN cDNA 1700008P20 (Predicted). (232 aa) |
| | Chp2 | Calcineurin B homologous protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to th [...] (196 aa) |
| | Tnnc1 | Troponin C1, slow skeletal and cardiac type. (161 aa) |
| | Capn9 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease. Belongs to the peptidase C2 family. (690 aa) |
| | Rptn | Repetin. (1116 aa) |
| | LOC100911951 | Kv channel-interacting protein 2x. (252 aa) |
| | S100z | Protein S100; Belongs to the S-100 family. (99 aa) |
| | Lpcat1 | Lysophosphatidylcholine acyltransferase 1; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent (By similarity). Mediates the conversion of 1-acyl-sn-glycero-3- phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1- myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. Involved in the regulation of lipid droplet number and size (By similarity). (534 aa) |
| | Mylpf | Myosin regulatory light chain 2, skeletal muscle isoform. (169 aa) |
| | Duox2 | Dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. (1517 aa) |
| | Calb2 | Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (271 aa) |
| | Calm3 | Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium- dependent inactivation of CACNA1C. Positively regulates calcium- activated potassium channel activity of KCNN2. (149 aa) |
| | Letm1 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity). (739 aa) |
| | Lpcat2 | Lysophosphatidylcholine acyltransferase 2; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, ac [...] (544 aa) |
| | Scgn | Secretagogin. (276 aa) |
| | Plcd4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration [...] (786 aa) |
| | Fkbp10 | Peptidylprolyl isomerase. (581 aa) |
| | Cetn1 | Centrin 1. (172 aa) |
| | Nkd2 | Naked cuticle 2 homolog (Drosophila) (Predicted). (458 aa) |
| | Rcn2 | Reticulocalbin-2; Not known. Binds calcium; Belongs to the CREC family. (320 aa) |
| | Myl12a | Myosin regulatory light chain RLC-A; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). (172 aa) |
| | Guca1b | Guanylate cyclase activator 1B (Predicted), isoform CRA_a. (201 aa) |
| | Guca1a | Guanylate cyclase activator 1a (Retina) (Predicted), isoform CRA_a. (202 aa) |
| | Sparcl1 | SPARC-like protein 1. (634 aa) |
| | Tnnc2 | Troponin C2, fast skeletal type. (160 aa) |
| | Necab2 | N-terminal EF-hand calcium-binding protein 2; May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. (352 aa) |
| | Cabp5 | Calcium binding protein 5 (Predicted), isoform CRA_b. (173 aa) |
| | Pdcd6 | Programmed cell death protein 6; Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair (By similarity). Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (By similarity). Involved in ER-Golgi transport. Regulates ER-Golgi transport by p [...] (191 aa) |
| | Cib3 | Calcium and integrin-binding family member 3. (187 aa) |
| | Nkd1 | NKD inhibitor of WNT-signaling pathway 1. (471 aa) |
| | Plch2 | Phosphoinositide phospholipase C. (1137 aa) |
| | Eps15l1 | Epidermal growth factor receptor pathway substrate 15-like 1. (909 aa) |
| | Pef1 | Peflin; Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is [...] (283 aa) |
| | Rcn1 | Reticulocalbin 1 (Predicted), isoform CRA_a. (325 aa) |
| | Prkcsh | Protein kinase C substrate 80K-H (Predicted), isoform CRA_b. (525 aa) |
| | Sparc | SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity; Belongs to the SPARC family. (301 aa) |
| | Ehd2 | EH domain-containing protein 2; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane. Regulates the equilibrium between cell surface- associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane. (543 aa) |
| | Micu3 | Mitochondrial calcium uptake family, member 3. (499 aa) |
| | S100a1 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer (By similarity). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity (By similarity). Belongs to the S-100 family. (94 aa) |
| | Efhb | EF hand domain family, member B. (946 aa) |
| | S100a16 | S100 calcium binding protein A16 (Predicted), isoform CRA_a; Belongs to the S-100 family. (123 aa) |
| | S100a4 | Protein S100-A4; Belongs to the S-100 family. (101 aa) |
| | S100a5 | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites. (93 aa) |
| | S100a6 | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity); Belongs to the S-100 family. (89 aa) |
| | S100a8 | Protein S100-A8; S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH- oxidase. Activates NADPH-oxidase by facilitat [...] (89 aa) |
| | Efcab6 | EF-hand calcium-binding domain 6. (1483 aa) |
| | S100a11 | Protein S100-A11; Facilitates the differentiation and the cornification of keratinocytes. (98 aa) |
| | Pls1 | Plastin 1. (630 aa) |
| | Fkbp14 | Peptidylprolyl isomerase. (211 aa) |
| | Cib4 | Calcium and integrin-binding family member 4. (185 aa) |
| | Efcab7 | EF-hand calcium-binding domain 7. (628 aa) |
| | Spata21 | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids. (685 aa) |
| | Crnn | Cornulin. (525 aa) |
| | Capn3 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. (821 aa) |
| | Ncs1 | Neuronal calcium sensor 1; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel; Belongs to the recoverin family. (190 aa) |
| | Calb1 | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. (261 aa) |
| | Ehd4 | EH-domain-containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (541 aa) |
| | Cgref1 | Cell growth regulator with EF hand domain protein 1; Mediates cell-cell adhesion in a calcium-dependent manner. Able to inhibit growth in several cell lines. (326 aa) |
| | Ppp2r3a | Protein phosphatase 2 (Formerly 2A), regulatory subunit B'', alpha, isoform CRA_a. (1150 aa) |
| | Necab1 | N-terminal EF-hand calcium-binding protein 1. (352 aa) |
| | Gca | Grancalcin (Predicted). (220 aa) |
| | Hpca | Neuron-specific calcium-binding protein hippocalcin; Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (By similarity). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases. (193 aa) |
| | Calu | Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma- carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). (315 aa) |
| | Efcab3 | EF-hand calcium-binding domain-containing protein 3. (432 aa) |
| | Smoc1 | SPARC-related modular calcium binding protein 1. (452 aa) |
| | Fkbp9 | Peptidyl-prolyl cis-trans isomerase FKBP9; PPIases accelerate the folding of proteins during protein synthesis. (570 aa) |
| | Rasgrp1 | RAS guanyl-releasing protein 1; Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T- lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (By similarity). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic [...] (795 aa) |
| | Vsnl1 | Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. (191 aa) |
| | Hpcal1 | Hippocalcin-like protein 1; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; Belongs to the recoverin family. (193 aa) |
| | Ppp3r2 | Calcineurin subunit B type 2; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. (176 aa) |
| | Kcnip1 | Kv channel-interacting protein 1; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND2/Kv4.2 currents. In vitro, modulates KCND1/Kv4.1 currents (By similarity). Increases the presence of KCND2 at the cell surface. (236 aa) |
| | Gnptab | N-acetylglucosamine-1-phosphate transferase subunits alpha and beta. (1228 aa) |
| | S100g | Protein S100-G. (79 aa) |
| | Rcvrn | Recoverin. (202 aa) |
| | LOC100361655 | RCG33642-like. (358 aa) |
| | Dgkg | Diacylglycerol kinase gamma; Belongs to the eukaryotic diacylglycerol kinase family. (788 aa) |
| | S100b | Protein S100-B; Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic pr [...] (92 aa) |
| | F1M053_RAT | EF-hand domain-containing protein; Belongs to the S-100 family. (116 aa) |
| | Cabp1 | Calcium-binding protein 1; Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling (By similarity). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhi [...] (314 aa) |
| | Cabp4 | Calcium binding protein 4 (Predicted). (271 aa) |
| | Caln1 | Calcium-binding protein 8; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning. (261 aa) |
