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Sema5a Sema5a Sema6d Sema6d Sema4d Sema4d Sema5b Sema5b Sema4b Sema4b Sema3g Sema3g Sema3e Sema3e Sema3c Sema3c Sema6b Sema6b Sema3b Sema3b Sema4a Sema4a Sema6c Sema6c Sema3a Sema3a Sema4g Sema4g Sema4c Sema4c Sema7a Sema7a Sema3d Sema3d Sema4f Sema4f Sema6a Sema6a Sema3f Sema3f
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sema5aSemaphorin-5A; Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing e [...] (1080 aa)
Sema6dSemaphorin 6D; Belongs to the semaphorin family. (1069 aa)
Sema4dSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
Sema5bSemaphorin 5B. (1092 aa)
Sema4bSemaphorin 4B; Belongs to the semaphorin family. (819 aa)
Sema3gSemaphorin 3G; Belongs to the semaphorin family. (780 aa)
Sema3eSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (Semaphorin) 3E (Predicted); Belongs to the semaphorin family. (775 aa)
Sema3cSemaphorin 3C; Belongs to the semaphorin family. (757 aa)
Sema6bSemaphorin-6B; May play a role in both peripheral and central nervous system development. (887 aa)
Sema3bSemaphorin 3B; Belongs to the semaphorin family. (749 aa)
Sema4aRCG62756, isoform CRA_a; Belongs to the semaphorin family. (762 aa)
Sema6cSemaphorin-6C; Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. (960 aa)
Sema3aSemaphorin-3A; May be involved in guiding growing axons towards their targets by forming a molecular boundary that instructs axons to engage in the formation of specific nerve tracts. Binds to neuropilin. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity). (772 aa)
Sema4gSemaphorin 4G; Belongs to the semaphorin family. (837 aa)
Sema4cSemaphorin 4C; Belongs to the semaphorin family. (834 aa)
Sema7aSema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (Semaphorin) 7A (Predicted); Belongs to the semaphorin family. (666 aa)
Sema3dSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
Sema4fSemaphorin-4F; Probable cell surface receptor that regulates oligodendroglial precursor cell migration (By similarity). Might also regulate differentiation of oligodendroglial precursor cells. Has growth cone collapse activity against retinal ganglion-cell axons ; Belongs to the semaphorin family. (776 aa)
Sema6aSemaphorin 6A; Belongs to the semaphorin family. (1031 aa)
Sema3fSemaphorin 3F; Belongs to the semaphorin family. (802 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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