STRINGSTRING
Msn Msn Myo10 Myo10 Ptpn4 Ptpn4 Jak1 Jak1 Frmd3 Frmd3 Epb41l2 Epb41l2 Ptpn13 Ptpn13 Ptpn3 Ptpn3 Frmpd2 Frmpd2 Tyk2 Tyk2 Ezr Ezr Epb41l5 Epb41l5 Frmd5 Frmd5 Frmd7 Frmd7 Rdx Rdx Mylip Mylip Epb41l3 Epb41l3 Tln1 Tln1 Myo7b Myo7b Myo7a Myo7a Frmpd1 Frmpd1 Farp1 Farp1 Plekhh1 Plekhh1 Frmd4b Frmd4b Nf2 Nf2 Frmpd4 Frmpd4 D3ZUF0_RAT D3ZUF0_RAT Ptk2b Ptk2b Krit1 Krit1 Fermt1 Fermt1 Fermt3 Fermt3 Frmd8 Frmd8 Plekhh3 Plekhh3 Farp2 Farp2 Ptk2 Ptk2 LOC100911769 LOC100911769 Epb41l4b Epb41l4b Ptpn14 Ptpn14 Jak2 Jak2 Myo15a Myo15a Epb41 Epb41 Epb41l1 Epb41l1 Frmd6 Frmd6 Fermt2 Fermt2 Ptpn21 Ptpn21
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MsnMoesin; Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane [...] (577 aa)
Myo10Unconventional myosin-X; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by traf [...] (2060 aa)
Ptpn4Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (926 aa)
Jak1Tyrosine-protein kinase. (1153 aa)
Frmd3FERM domain-containing 3. (500 aa)
Epb41l2Similar to protein 4.1G (Predicted), isoform CRA_a. (996 aa)
Ptpn13Tyrosine-protein phosphatase non-receptor type 13; Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. (2455 aa)
Ptpn3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (1018 aa)
Frmpd2Uncharacterized protein. (623 aa)
Tyk2Tyrosine-protein kinase. (1186 aa)
EzrEzrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). (586 aa)
Epb41l5Band 4.1-like protein 5; May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells. (731 aa)
Frmd5FERM domain-containing 5. (485 aa)
Frmd7FERM domain-containing 7. (703 aa)
RdxRadixin. (583 aa)
MylipE3 ubiquitin-protein ligase MYLIP; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. (445 aa)
Epb41l3Erythrocyte protein band 4.1-like 3, isoform CRA_d. (1105 aa)
Tln1RCG55135, isoform CRA_b. (2541 aa)
Myo7bMyosin VIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2152 aa)
Myo7aMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2177 aa)
Frmpd1FERM and PDZ domain-containing 1. (1371 aa)
Farp1FERM, ARHGEF and pleckstrin domain-containing protein 1; May play a role in semaphorin signaling (By similarity). Functions as guanine nucleotide exchange factor for RAC1. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses. (1049 aa)
Plekhh1Pleckstrin homology, MyTH4 and FERM domain-containing H1. (1349 aa)
Frmd4bFERM domain-containing 4B. (1035 aa)
Nf2Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...] (591 aa)
Frmpd4Similar to KIAA0316 protein (Predicted). (1705 aa)
D3ZUF0_RATUncharacterized protein. (504 aa)
Ptk2bProtein-tyrosine kinase 2-beta; Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promot [...] (1009 aa)
Krit1KRIT1, ankyrin repeat-containing. (736 aa)
Fermt1Fermitin family member 1. (677 aa)
Fermt3Fermitin family member 3. (665 aa)
Frmd8FERM domain-containing protein 8; Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity). (466 aa)
Plekhh3Pleckstrin homology domain-containing family H member 3. (791 aa)
Farp2FERM, RhoGEF and pleckstrin domain protein 2 (Predicted). (1060 aa)
Ptk2Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required f [...] (1067 aa)
LOC100911769Band 4.1-like protein 1; May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. (829 aa)
Epb41l4bBand 4.1-like protein 4B; Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18. Involved in the regulation of the circumferential actomyosin belt in epithelial cells. Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing. May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation. (745 aa)
Ptpn14Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1189 aa)
Jak2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1132 aa)
Myo15aMyosin XVA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3508 aa)
Epb41Erythrocyte membrane protein band 4.1. (866 aa)
Epb41l1Band 4.1-like protein 1. (1551 aa)
Frmd6FERM domain-containing protein 6. (614 aa)
Fermt2Fermitin family member 2. (695 aa)
Ptpn21Tyrosine-protein phosphatase non-receptor type 21; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1175 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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