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| | Il13ra2 | Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13). (385 aa) |
| | Nrcam | Neuronal cell adhesion molecule; Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons (By similarity). Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvi [...] (1213 aa) |
| | Mpl | Myeloproliferative leukemia virus oncogene (Predicted), isoform CRA_b. (644 aa) |
| | L1cam | Neural cell adhesion molecule L1; Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. (1333 aa) |
| | Il2rb | Interleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). (538 aa) |
| | Sdk2 | Sidekick cell adhesion molecule 2. (2175 aa) |
| | A0A0G2K8R1_RAT | Uncharacterized protein. (551 aa) |
| | Mybpc1 | Myosin-binding protein C, slow-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. (1184 aa) |
| | Ncam2 | Neural cell adhesion molecule 2. (836 aa) |
| | Ptprh | Protein tyrosine phosphatase, receptor type, H. (971 aa) |
| | Hcfc1 | Host cell factor C1. (2034 aa) |
| | Myom1 | Myomesin 1. (1688 aa) |
| | Insrr | Insulin receptor-related protein; Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. (1300 aa) |
| | Itgb4 | Integrin beta-4; Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. (1807 aa) |
| | Rimbp2 | RIMS-binding protein 2; Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B; Belongs to the RIMBP family. (1238 aa) |
| | Fndc1 | Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling. (1831 aa) |
| | Prlr | Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin; Belongs to the type I cytokine receptor family. Type 1 subfamily. (609 aa) |
| | Mid1 | E3 ubiquitin-protein ligase Midline-1; Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination; Belongs to the TRIM/RBCC family. (667 aa) |
| | Ptprb | Protein tyrosine phosphatase, receptor type, B. (2238 aa) |
| | Tnc | Tenascin C. (2019 aa) |
| | Ncam1 | Neural cell adhesion molecule 1; This protein is a cell adhesion molecule involved in neuron- neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. (1016 aa) |
| | Cntn1 | Contactin-1; Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurit [...] (1021 aa) |
| | Fank1 | Fibronectin type 3 and ankyrin repeat domains 1 protein; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis. (344 aa) |
| | Prtg | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. (1193 aa) |
| | Robo2 | Roundabout guidance receptor 2. (1512 aa) |
| | Fsd1l | Fibronectin type III and SPRY domain-containing 1-like. (508 aa) |
| | Astn2 | Astrotactin 2. (1354 aa) |
| | Ephb2 | Eph receptor B2. (986 aa) |
| | Ptprj | Protein tyrosine phosphatase, receptor type, J. (1288 aa) |
| | Trim46 | Tripartite motif-containing protein 46; Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration; Belongs to the TRIM/RBCC family. (561 aa) |
| | Hcfc2 | Host cell factor 2. (723 aa) |
| | Il7r | Interleukin 7 receptor (Predicted). (457 aa) |
| | Mid2 | Midline 2 (Predicted). (705 aa) |
| | Robo1 | Roundabout homolog 1; Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (By similarity). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migratio [...] (1640 aa) |
| | Tyro3 | Tyrosine-protein kinase receptor TYRO3; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival [...] (880 aa) |
| | Csf2rb | Colony-stimulating factor 2 receptor beta common subunit. (895 aa) |
| | Phyhipl | Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system. Belongs to the PHYHIP family. (375 aa) |
| | Mdga2 | MAM domain-containing glycosylphosphatidylinositol anchor protein 2; May be involved in cell-cell interactions. (925 aa) |
| | Il3ra | Interleukin 3 receptor subunit alpha. (386 aa) |
| | Dscam | Down syndrome cell adhesion molecule homolog; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (By similarity). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor [...] (1849 aa) |
| | Ifngr2 | Interferon gamma receptor 2 (Predicted). (330 aa) |
| | Boc | BOC cell adhesion-associated, oncogene-regulated. (1108 aa) |
| | Epha5 | Ephrin type-A receptor 5; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in [...] (1039 aa) |
| | Tnn | Tenascin N. (1562 aa) |
| | Flrt2 | Leucine-rich repeat transmembrane protein FLRT2; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signal [...] (660 aa) |
| | Ush2a | Usherin; Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. (5162 aa) |
| | Il2rg | Interleukin 2 receptor, gamma (Severe combined immunodeficiency), isoform CRA_a. (368 aa) |
| | Vasn | RCG49849. (673 aa) |
| | Il12b | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (335 aa) |
| | Ptprv | Receptor-type tyrosine-protein phosphatase V; May function in signaling pathways during bone remodeling, as well as serve a broader role in cell interactions associated with differentiation in bone and testis. Associated with differentiation in bone and testis. (1711 aa) |
| | Lrfn5 | Leucine-rich repeat and fibronectin type-III domain-containing protein 5; Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity). (719 aa) |
| | Cntn4 | Contactin-4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis; Belongs to the immunoglobulin superfamily. Contactin family. (1026 aa) |
| | Cntn3 | Contactin-3; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. (1028 aa) |
| | Il5ra | Interleukin 5 receptor subunit alpha. (448 aa) |
| | Fndc9 | Fibronectin type III domain-containing 9. (226 aa) |
| | Lrrn3 | Leucine-rich repeat neuronal protein 3. (707 aa) |
| | Ptprz1 | Receptor-type tyrosine-protein phosphatase zeta; Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). (2316 aa) |
| | Lrrn1 | Leucine-rich repeat neuronal protein 1. (716 aa) |
| | Ndnf | Uncharacterized protein. (496 aa) |
| | Cntn5 | Contactin-5; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system. (1099 aa) |
| | Neo1 | Neogenin; Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response (By similarity); Belongs to the immunoglobulin superfamily. DCC family. (1209 aa) |
| | Trim9 | E3 ubiquitin-protein ligase TRIM9; E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions (By similarity). May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. (710 aa) |
| | Il12rb2 | Interleukin 12 receptor subunit beta 2. (869 aa) |
| | Epha7 | Ephrin type-A receptor 7; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repel [...] (998 aa) |
| | Il23r | Interleukin 23 receptor. (624 aa) |
| | Ephb1 | Ephrin type-B receptor 1; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotempora [...] (984 aa) |
| | Tspoap1 | Peripheral-type benzodiazepine receptor-associated protein 1. (1845 aa) |
| | Fndc8 | Fibronectin type III domain-containing 8. (322 aa) |
| | Csf3r | Colony stimulating factor 3 receptor (Granulocyte) (Predicted), isoform CRA_b. (838 aa) |
| | Atf7ip | Activating transcription factor 7-interacting protein. (1309 aa) |
| | Cntn2 | Contactin-2; May play a role in the initial growth and guidance of axons. May be involved in cell adhesion. In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region (By similarity). Belongs to the immunoglobulin superfamily. Contactin family. (1040 aa) |
| | Epha2 | Eph receptor A2 (Predicted). (977 aa) |
| | Igsf9b | Protein turtle homolog B; Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion (By similarity); Belongs to the immunoglobulin superfamily. Turtle family. (1328 aa) |
| | Lrrn2 | Leucine-rich repeat neuronal 2. (750 aa) |
| | Phyhip | Phytanoyl-CoA hydroxylase-interacting protein; Its interaction with PHYH suggests a role in the development of the central system; Belongs to the PHYHIP family. (330 aa) |
| | Lrfn2 | Leucine-rich repeat and fibronectin type-III domain-containing protein 2; Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of GRIN1 and GRIN2A NMDA receptor subunits. May play a role in redistributing DLG4 to the cell periphery (By similarity). (788 aa) |
| | F3 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa) |
| | Myom2 | Myomesin 2. (1464 aa) |
| | Lifr | Leukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity). (1093 aa) |
| | Cdon | Cell adhesion molecule-related/down-regulated by oncogenes; Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). (1256 aa) |
| | Ifngr1 | Interferon gamma receptor 1. (464 aa) |
| | Il22ra2 | Interleukin-22 receptor subunit alpha-2; Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses; Belongs to the type II cytokine receptor family. (229 aa) |
| | Mybpc3 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. (1274 aa) |
| | Egflam | Pikachurin; Involved in both the normal retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity). (1005 aa) |
| | Epor | Erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase (By similarity). (507 aa) |
| | Il13ra1 | Interleukin 13 receptor, alpha 1, isoform CRA_b. (426 aa) |
| | Lrit1 | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction. (617 aa) |
| | Il6st | Interleukin-6 receptor subunit beta; Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6. Essential for survival of moto [...] (930 aa) |
| | Igf1r | Insulin-like growth factor 1 receptor alpha chain; Receptor tyrosine kinase which mediates actions of insulin- like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates ( [...] (1367 aa) |
| | Ephb6 | Ephrin type-B receptor 6; Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity). (1013 aa) |
| | Fn1 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2477 aa) |
| | Obsl1 | Obscurin-like protein 1; Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (By similarity). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. (1805 aa) |
| | Il11ra1 | Interleukin-11 receptor subunit alpha; Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. (431 aa) |
| | Ptprk | Receptor-like protein tyrosine phosphatase kappa. (1439 aa) |
| | Il4r | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). (801 aa) |
| | Il21r | Interleukin 21 receptor, isoform CRA_a. (521 aa) |
| | Il10ra | Interleukin 10 receptor subunit alpha. (569 aa) |
| | Sned1 | Sushi, nidogen and EGF-like domain-containing protein 1. (1397 aa) |
| | Trim36 | Tripartite motif protein 36 (Predicted). (729 aa) |
| | Dscaml1 | Down syndrome cell adhesion molecule-like 1 (Predicted). (2111 aa) |
| | Mertk | Tyrosine-protein kinase Mer; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation [...] (994 aa) |
| | Epha1 | Eph receptor A1 (Predicted). (977 aa) |
| | Vwa1 | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. (415 aa) |
| | Il12rb1 | Interleukin 12 receptor subunit beta 1. (738 aa) |
| | Fsd2 | Fibronectin type III and SPRY domain-containing 2. (746 aa) |
| | Lrfn4 | Leucine-rich repeat and fibronectin type-III domain-containing protein 4; Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). (636 aa) |
| | Speg | Striated muscle-specific serine/threonine-protein kinase; Isoform 2 may have a role in regulating the growth and differentiation of arterial smooth muscle cells; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (3259 aa) |
| | Mybphl | Myosin-binding protein H-like; Belongs to the immunoglobulin superfamily. MyBP family. (355 aa) |
| | Tie1 | Tyrosine kinase with immunoglobulin-like and EGF-like domains 1. (1137 aa) |
| | Fndc7 | Similar to RIKEN cDNA E230011A21 gene (Predicted), isoform CRA_a. (737 aa) |
| | Col7a1 | Procollagen, type VII, alpha 1 (Predicted). (2588 aa) |
| | Axl | Axl receptor tyrosine kinase. (888 aa) |
| | Il6r | Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. (460 aa) |
| | Lrfn3 | Leucine-rich repeat and fibronectin type-III domain-containing protein 3; Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity); Belongs to the LRFN family. (626 aa) |
| | Ptpru | Protein tyrosine phosphatase, receptor type, U. (1446 aa) |
| | Il20rb | Interleukin 20 receptor beta IL-20R2. (308 aa) |
| | Ifnar1 | Interferon (Alpha and beta) receptor 1 (Predicted), isoform CRA_a. (593 aa) |
| | Igfn1 | Immunoglobulin-like and fibronectin type III domain-containing 1. (2837 aa) |
| | Trim67 | Tripartite motif-containing 67. (770 aa) |
| | Tek | Endothelial-specific receptor tyrosine kinase. (1120 aa) |
| | Flrt1 | Similar to fibronectin leucine rich transmembrane protein 1 (Predicted). (674 aa) |
| | Tril | TLR4 interactor with leucine rich repeats; Component of the TLR4 signaling complex. Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion and the inflammatory response (By similarity). (811 aa) |
| | Fndc3b | Fibronectin type III domain-containing 3B. (1207 aa) |
| | Ptprg | Protein tyrosine phosphatase, receptor type, G. (1372 aa) |
| | Kalrn | Kalirin; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation. (2977 aa) |
| | Igdcc3 | Immunoglobulin superfamily, DCC subclass, member 3. (812 aa) |
| | Ephb3 | Eph receptor B3 (Predicted). (1048 aa) |
| | Osmr | Oncostatin-M-specific receptor subunit beta; Associates with IL31RA to form the IL31 receptor. Binds IL31 and activates STAT1, STAT3 and STAT5. Capable of transducing OSM- specific signaling events (By similarity). The OSM/OSM-R system is pivotal in the differentiation of oval cells into hepatocytes, thereby promoting liver regeneration; Belongs to the type I cytokine receptor family. Type 2 subfamily. (962 aa) |
| | Mdga1 | MAM domain-containing glycosylphosphatidylinositol anchor protein 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. (943 aa) |
| | Ptprt | Protein tyrosine phosphatase, receptor type, T (Predicted). (1269 aa) |
| | Il20ra | Interleukin 20 receptor, alpha (Predicted). (543 aa) |
| | Epha3 | Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] (984 aa) |
| | Ptpro | Protein tyrosine phosphatase, receptor type, O, isoform CRA_b. (1216 aa) |
| | Ghr | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway. (638 aa) |
| | Mybph | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Belongs to the immunoglobulin superfamily. MyBP family. (485 aa) |
| | Robo4 | Roundabout homolog 4; Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (By similarity); Belongs to the immunoglobulin superfamily. ROBO family. (961 aa) |
| | Umodl1 | Uromodulin-like 1. (1325 aa) |
| | Lepr | Leptin receptor; Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive fun [...] (895 aa) |
| | Myom3 | Myomesin 3. (1438 aa) |
| | Fndc3c1 | Fibronectin type III domain-containing 3C1. (1329 aa) |
| | Cntn6 | Contactin-6; Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. May be involved in motor coordination. (1026 aa) |
| | Lrrn4 | Leucine-rich repeat neuronal 4. (735 aa) |
| | Ifnlr1 | Interferon, lambda receptor 1. (530 aa) |
| | Fndc5 | Fibronectin type III domain-containing protein 5; [Irisin]: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA (By similarity). (209 aa) |
| | Abi3bp | ABI family member 3-binding protein. (1148 aa) |
| | Epha6 | Ephrin type-A receptor 6; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). (759 aa) |
| | Insr | Insulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...] (1384 aa) |
| | Col20a1 | Collagen type XX alpha 1 chain. (1362 aa) |
| | Nphs1 | Nephrin; Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion; Belongs to the immunoglobulin superfamily. (1252 aa) |
| | Epha4 | Eph receptor A4. (986 aa) |
| | Ptprm | Protein tyrosine phosphatase, receptor type, M. (1486 aa) |
| | Epha10 | EPH receptor A10. (1007 aa) |
| | Lrfn1 | Leucine-rich repeat and fibronectin type III domain-containing protein 1; Promotes neurite outgrowth in hippocampal neurons (By similarity). Involved in the regulation of the differentiation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1. (766 aa) |
| | Rimbp3 | RIMS-binding protein 3. (1612 aa) |
| | Crlf1 | Cytokine receptor-like factor 1 (Predicted). (425 aa) |
| | LOC100911068 | Roundabout homolog 4-like. (1021 aa) |
| | Nfasc | Neurofascin; Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Isoform 2/isoform 3 may be responsible for mediating and signaling axon-glial interaction during the early stages of myelination; Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. (1240 aa) |
| | Il10rb | Similar to class II cytokine receptor 4 (Predicted), isoform CRA_a. (351 aa) |
| | Robo3 | Roundabout homolog 3 (Drosophila) (Predicted). (1305 aa) |
| | Fndc11 | Fibronectin type III domain containing 11. (369 aa) |
| | Mybpc2 | Myosin binding protein C, fast-type (Predicted). (1153 aa) |
| | Mylk | Myosin light chain kinase. (1961 aa) |
| | Fndc3a | Fibronectin type III domain containing 3a (Predicted), isoform CRA_a. (1170 aa) |
| | Dcc | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (By similarity). Belongs to the immunoglobulin superfamily. DCC family. (1426 aa) |
| | Igdcc4 | Immunoglobulin superfamily, DCC subclass, member 4. (1239 aa) |
| | Col14a1 | Collagen type XIV alpha 1 chain. (1794 aa) |
| | Ptprc | Receptor-type tyrosine-protein phosphatase C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). (1273 aa) |
| | Pomgnt2 | Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D- mannosylprotein. Involved in the biosynthesis of the phosphorylated O- mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affini [...] (580 aa) |
| | Il31ra | Interleukin 31 receptor A. (720 aa) |
| | Csf2ra | Colony-stimulating factor 2 receptor alpha subunit. (382 aa) |
| | Cmya5 | Cardiomyopathy-associated 5. (3943 aa) |
| | Ptprs | Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain develop [...] (1903 aa) |
| | Fsd1 | Similar to fibronectin type 3 and SPRY domain-containing protein, isoform CRA_a. (496 aa) |
| | Ifnar2 | Interferon alpha and beta receptor subunit 2. (516 aa) |
| | Cntfr | Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity. (372 aa) |
| | Crlf2 | Cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5 (By similarity). Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system; Belongs to the type I cytokine receptor family. Type 5 subfamily. (360 aa) |
| | Trim42 | Tripartite motif-containing 42. (723 aa) |
| | Ptprd | Protein tyrosine phosphatase, receptor type, D. (1937 aa) |
| | Chl1 | Cell adhesion molecule L1-like. (1210 aa) |
| | Ebi3 | Epstein-Barr virus-induced 3. (228 aa) |
| | Ephb4 | RCG21674, isoform CRA_a. (987 aa) |
| | Crlf3 | Cytokine receptor-like factor 3. (400 aa) |
| | Tnr | Tenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repul [...] (1358 aa) |
| | Ptprf | Receptor-type tyrosine-protein phosphatase F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity. (1904 aa) |
| | Ros1 | Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation [...] (2338 aa) |
| | Igsf9 | Protein turtle homolog A; Functions in dendrite outgrowth and synapse maturation. (1179 aa) |
| | Ptprq | Phosphatidylinositol phosphatase PTPRQ; Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5- bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is un [...] (2302 aa) |
