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| | Ankrd29-2 | Ankyrin repeat domain 29. (36 aa) |
| | Ripk4 | Receptor-interacting serine-threonine kinase 4. (786 aa) |
| | Sowahb | Sosondowah ankyrin repeat domain family member B. (767 aa) |
| | Ankrd45 | ANK_REP_REGION domain-containing protein. (163 aa) |
| | Trpv2 | Transient receptor potential cation channel subfamily V member 2; Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity). (761 aa) |
| | Anks3 | Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney. (663 aa) |
| | Tp53bp2 | Tumor protein p53-binding protein, 2. (1128 aa) |
| | Acbd6 | Acyl-CoA-binding domain-containing protein 6; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids (By similarity). (282 aa) |
| | Fem1c | Fem-1 homolog c (C.elegans) (Predicted). (617 aa) |
| | Zdhhc17 | Palmitoyltransferase ZDHHC17; Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg(2+) transport; Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. (622 aa) |
| | Map3k19 | Protein kinase domain-containing protein. (1216 aa) |
| | Ankar | Ankyrin and armadillo repeat-containing. (1440 aa) |
| | Lrrk2 | Leucine-rich repeat kinase 2. (2526 aa) |
| | Asb12 | Ankyrin repeat and SOCS box-containing 12. (308 aa) |
| | Caskin2 | Cask-interacting protein 2 (Predicted). (1200 aa) |
| | Bcorl1 | BCL6 co-repressor-like 1. (1788 aa) |
| | Ankef1 | Ankyrin repeat and EF-hand domain-containing 1. (775 aa) |
| | Ankib1 | RBR-type E3 ubiquitin transferase. (1085 aa) |
| | Hectd1 | HECT domain E3 ubiquitin protein ligase 1. (2610 aa) |
| | Ankrd24 | Ankyrin repeat domain 24 (Predicted), isoform CRA_d. (903 aa) |
| | Cdkn2b | Cyclin-dependent kinase 4 inhibitor B; Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity); Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. (124 aa) |
| | Trpc6 | Transient receptor potential cation channel, subfamily C, member 6, isoform CRA_b; Belongs to the transient receptor (TC 1.A.4) family. (930 aa) |
| | Tex14 | Inactive serine/threonine-protein kinase TEX14; Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodie [...] (1446 aa) |
| | Fem1b | Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet (By similarity). Functions as an adapter/mediator in replication stress- induced signaling that leads to the activation of CHEK1 (By similarity); Belongs to the fem-1 family. (627 aa) |
| | Kank3 | KN motif and ankyrin repeat domains 3. (808 aa) |
| | Trpa1 | Transient receptor potential cation channel subfamily A member 1; Receptor-activated non-selective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function. Shows 8- fold preference for divalent over monovalent cations. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of irritants, such as allylthiocyanate (AITC) found in mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an irritant from tears gas and veh [...] (1125 aa) |
| | Nfkbia | NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (By similarity). (314 aa) |
| | Ankrd9 | Ankyrin repeat domain 9. (326 aa) |
| | Invs | Inversin. (1003 aa) |
| | Cdkn2c | Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4), isoform CRA_a. (168 aa) |
| | Ankrd49 | Ankyrin repeat domain 49. (239 aa) |
| | Asb8 | Ankyrin repeat and SOCS box-containing protein 8 (Predicted), isoform CRA_a. (288 aa) |
| | Ankrd54 | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation. (310 aa) |
| | Ankrd13c | Ankyrin repeat domain 13C. (555 aa) |
| | Ankrd44 | Ankyrin repeat domain 44. (993 aa) |
| | Mtpn | Myotrophin; Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity). Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. (118 aa) |
| | Tnks | Poly [ADP-ribose] polymerase. (1317 aa) |
| | Poteg | POTE ankyrin domain family, member G. (175 aa) |
| | Ostf1 | Osteoclast-stimulating factor 1; Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity. (214 aa) |
| | Lrrk1 | Leucine-rich repeat kinase 1. (2013 aa) |
| | Trpc7 | Transient receptor potential cation channel, subfamily C, member 7; Belongs to the transient receptor (TC 1.A.4) family. (862 aa) |
| | Uaca | Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1410 aa) |
| | Ank2 | Ankyrin 2. (3963 aa) |
| | Ppp1r13b | Protein phosphatase 1, regulatory subunit 13B. (1085 aa) |
| | Trpc3 | Short transient receptor potential channel 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3 (By similarity). May also be activated by internal calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC [...] (864 aa) |
| | Ankrd7 | Ankyrin repeat domain 7. (278 aa) |
| | Bard1 | BRCA1-associated RING domain protein 1; E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II [...] (768 aa) |
| | Tanc2 | Protein TANC2; Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. (2076 aa) |
| | Ankhd1 | Ankyrin repeat and KH domain-containing 1. (2615 aa) |
| | Ankmy2 | Ankyrin repeat and MYND domain-containing 2. (436 aa) |
| | Ehmt1 | Euchromatic histone lysine methyltransferase 1. (1289 aa) |
| | Agap1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1. (889 aa) |
| | Asz1 | Ankyrin repeat, SAM and basic leucine zipper domain-containing 1. (475 aa) |
| | Asap2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2. (844 aa) |
| | Trpc1 | Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. (809 aa) |
| | Sowaha | Sosondowah ankyrin repeat domain family member A. (552 aa) |
| | Nfkbiz | NFKB inhibitor zeta. (733 aa) |
| | Ilk | Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. (452 aa) |
| | Bcl3 | BCL3, transcription coactivator. (365 aa) |
| | Ankrd22 | Ankyrin repeat domain 22. (191 aa) |
| | Shank1 | SH3 and multiple ankyrin repeat domains protein 1; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function. (2167 aa) |
| | Notch1 | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination (By similarity). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (By similarity). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in angiogenesis; negatively regulates endothelial cell proliferation and mig [...] (2531 aa) |
| | Nfkb2 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a. (898 aa) |
| | Trpv1 | Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] (838 aa) |
| | Trpv3 | Transient receptor potential cation channel, subfamily V, member 3; Belongs to the transient receptor (TC 1.A.4) family. (791 aa) |
| | Ankrd28 | Ankyrin repeat domain 28. (1078 aa) |
| | Nfkbie | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon. (365 aa) |
| | Nfkbib | NF-kappa-B inhibitor beta; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. (359 aa) |
| | Asb1 | Ankyrin repeat and SOCS box-containing protein 1 (Predicted), isoform CRA_a. (335 aa) |
| | Mphosph8 | M-phase phosphoprotein 8; Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; [...] (851 aa) |
| | LOC100911911 | Similar to CLIP-170-related protein (Predicted). (547 aa) |
| | Asb16 | Similar to ankyrin repeat domain-containing SOCS box protein Asb-16 (Predicted). (453 aa) |
| | Ankrd53 | Ankyrin repeat domain 53. (511 aa) |
| | Ankrd46 | Ankyrin repeat domain-containing protein 46. (228 aa) |
| | Trank1 | Tetratricopeptide repeat and ankyrin repeat-containing 1. (2997 aa) |
| | Gabpb2 | GA-binding protein transcription factor subunit beta 2. (413 aa) |
| | Nfkb1 | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (973 aa) |
| | Dzank1 | Double zinc ribbon and ankyrin repeat domains 1. (757 aa) |
| | Agap2 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. (1186 aa) |
| | Asb6 | Ankyrin repeat and SOCS box-containing 6. (345 aa) |
| | Tnni3k | Serine/threonine-protein kinase TNNI3K; May play a role in cardiac physiology. (835 aa) |
| | Krit1 | KRIT1, ankyrin repeat-containing. (736 aa) |
| | F1LVF8_RAT | ANK_REP_REGION domain-containing protein. (137 aa) |
| | Ush1g | Usher syndrome 1G homolog (Human) (Predicted). (461 aa) |
| | Ankrd23 | Ankyrin repeat domain 23. (313 aa) |
| | Rnasel | Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent). (738 aa) |
| | Tanc1 | Protein TANC1; May be a scaffold component in the postsynaptic density. (1849 aa) |
| | Hace1 | E3 ubiquitin-protein ligase HACE1; E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defen [...] (909 aa) |
| | Notch4 | Notch homolog 4, isoform CRA_b. (1961 aa) |
| | Nfkbil1 | NF-kappa-B inhibitor-like protein 1; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity). (381 aa) |
| | Gpank1 | G patch domain and ankyrin repeats 1. (350 aa) |
| | Ankrd61 | Ankyrin repeat domain-containing protein 61. (418 aa) |
| | F1LX87_RAT | ANK_REP_REGION domain-containing protein. (729 aa) |
| | Dgki | Diacylglycerol kinase. (1050 aa) |
| | Ankrd11 | Ankyrin repeat domain 11. (2605 aa) |
| | Ankzf1 | Ankyrin repeat and zinc finger domain-containing protein 1; Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity). (722 aa) |
| | Espnl | Espin-like. (999 aa) |
| | Asb10 | Similar to ankyrin repeat-containing SOCS box protein 10 (Predicted). (465 aa) |
| | Dapk1 | Death-associated protein kinase 1. (1442 aa) |
| | Acap3 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3. (833 aa) |
| | Gabpb1l | GA-binding protein transcription factor, beta subunit 1-like. (304 aa) |
| | Git1 | ARF GTPase-activating protein GIT1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve ENTR1 and PTP [...] (752 aa) |
| | Acap2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). (809 aa) |
| | Ppp1r12c | Protein phosphatase 1 regulatory subunit. (784 aa) |
| | Aspg | 1-alkyl-2-acetylglycerophosphocholine esterase; Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities. Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GP [...] (564 aa) |
| | Ankrd12 | Ankyrin repeat domain 12 (Predicted), isoform CRA_b. (2047 aa) |
| | Asb14 | Ankyrin repeat and SOCS box protein 14; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (594 aa) |
| | Mib1 | Mindbomb E3 ubiquitin protein ligase 1. (1006 aa) |
| | Ankrd55 | Ankyrin repeat domain 55. (614 aa) |
| | Ankrd34c | Ankyrin repeat domain 34C. (534 aa) |
| | Gls2 | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation; Belongs to the glutaminase family. (579 aa) |
| | Ankrd2 | Ankyrin repeat domain 2. (332 aa) |
| | Zdhhc13 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (622 aa) |
| | Tonsl | Tonsoku-like protein; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double- strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity). Belongs to the Tonsoku family. (1367 aa) |
| | Ankrd13b | Ankyrin repeat domain 13B. (696 aa) |
| | Trpv6 | Transient receptor potential cation channel subfamily V member 6; Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vit [...] (727 aa) |
| | Ppp1r16a | Protein phosphatase 1, regulatory subunit 16A. (525 aa) |
| | Trpv5 | Transient receptor potential cation channel subfamily V member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (By similarity). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. [...] (723 aa) |
| | Ppp1r16b | Protein phosphatase 1, regulatory subunit 16B. (568 aa) |
| | Acap1 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1. (740 aa) |
| | Abtb1 | Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes (By similarity). (478 aa) |
| | Kank1 | KN motif and ankyrin repeat domains 1. (1358 aa) |
| | Ankfy1 | Ankyrin repeat and FYVE domain-containing 1. (1169 aa) |
| | Ankra2 | SLO-interacting ankyrin-containing protein. (313 aa) |
| | Myo16 | Unconventional myosin-XVI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity); In the C-terminal section; belongs to the NYAP family. (1912 aa) |
| | Ankle1 | Ankyrin repeat and LEM domain-containing 1. (535 aa) |
| | Mib2 | E3 ubiquitin-protein ligase MIB2; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. (953 aa) |
| | Asb13 | Ankyrin repeat and SOCS box-containing 13 (Predicted), isoform CRA_b. (278 aa) |
| | Dgkz | Diacylglycerol kinase zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Regulates RASGRP1 activity (By similarity). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Activates PIP5K1A activity via generation of phosphatidic acid (By similarity). (929 aa) |
| | Ankrd16 | Ankyrin repeat domain-containing protein 16; Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides. (370 aa) |
| | Ankrd1 | Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. (319 aa) |
| | Ankrd13d | Ankyrin repeat domain 13 family, member D (Predicted). (605 aa) |
| | Notch2 | Neurogenic locus notch homolog protein 2; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and pos [...] (2471 aa) |
| | Clpb | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. (707 aa) |
| | Cttnbp2 | Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance. (1649 aa) |
| | Osbpl1a | Oxysterol-binding protein-related protein 1; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol. (949 aa) |
| | Asb7 | Ankyrin repeat and SOCS box-containing 7 (Predicted). (318 aa) |
| | Agap3 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3. (812 aa) |
| | Pla2g6 | 85/88 kDa calcium-independent phospholipase A2; Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide- induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose- stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2- induced chemotaxis through regulation of F-actin polymerization at the pseudopods (By [...] (807 aa) |
| | Gls | Glutaminase kidney isoform, mitochondrial 65 kDa chain; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain. Belongs to the glutaminase family. (673 aa) |
| | Trpc5 | Transient receptor potential cation channel, subfamily C, member 5; Belongs to the transient receptor (TC 1.A.4) family. (973 aa) |
| | Ank3 | Ankyrin-3; Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (By similarity). (2615 aa) |
| | Shank3 | SH3 and multiple ankyrin repeat domains protein 3; Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex [...] (1741 aa) |
| | Potec-2 | Ankyrin repeat domain-containing protein 7-like. (276 aa) |
| | Asb2 | Ankyrin repeat and SOCS box protein 2; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. (634 aa) |
| | Fank1 | Fibronectin type 3 and ankyrin repeat domains 1 protein; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis. (344 aa) |
| | Psmd10 | 26S proteasome non-ATPase regulatory subunit 10; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module (By similarity). Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis (By similarity). (175 aa) |
| | Ankle2 | Ankyrin repeat and LEM domain-containing protein 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (By similarity). Belongs to the ANKLE2 family. (964 aa) |
| | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Plays a role in ciliogenesis (By similarity). (1086 aa) |
| | Ppp1r12a | Protein phosphatase 1 regulatory subunit 12A; Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity (By similarity). (1032 aa) |
| | Ppp1r12b | Protein phosphatase 1 regulatory subunit. (993 aa) |
| | Ankrd17 | Ankyrin repeat domain 17. (2524 aa) |
| | spergen-2 | Spergen-2. (500 aa) |
| | Ankrd27 | Ankyrin repeat domain 27. (1055 aa) |
| | Abtb2 | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. (1024 aa) |
| | Sncaip | Synuclein, alpha interacting protein (Synphilin) (Predicted), isoform CRA_a. (963 aa) |
| | LOC100910717 | Poly [ADP-ribose] polymerase. (1166 aa) |
| | Ankdd1b | ANK_REP_REGION domain-containing protein. (394 aa) |
| | Asb17 | Ankyrin repeat and SOCS box containing protein 17. (295 aa) |
| | Fem1a | Protein fem-1 homolog A; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. May participate in antiinflammatory signaling via its interaction with PTGER4 (By similarity); Belongs to the fem-1 family. (654 aa) |
| | Ankmy1 | Ankyrin repeat and MYND domain-containing 1. (1005 aa) |
| | Bank1 | B-cell scaffold protein with ankyrin repeats 1. (783 aa) |
| | Nfkbid | NFKB inhibitor delta. (327 aa) |
| | Notch3 | Neurogenic locus notch homolog protein 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/o [...] (2319 aa) |
| | Asb9 | Ankyrin repeat and SOCS box-containing 9. (344 aa) |
| | Espn | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] (838 aa) |
| | Caskin1 | Caskin-1; May link the scaffolding protein CASK to downstream intracellular effectors. (1430 aa) |
| | Rfxank | Regulatory factor X-associated ankyrin-containing protein. (284 aa) |
| | Ehmt2 | Euchromatic histone lysine methyltransferase 2. (1263 aa) |
| | Potec | POTE ankyrin domain family, member C. (260 aa) |
| | Trpc4 | Short transient receptor potential channel 4; Thought to form non-selective a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium- selective (By similarity). May also be activated by intracellular calcium store depletion; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily. (977 aa) |
| | Ankrd50 | Ankyrin repeat domain 50. (1427 aa) |
| | Asb18 | Ankyrin repeat and SOCS box-containing 18. (466 aa) |
| | Gabpb1 | GA-binding protein transcription factor subunit beta 1. (304 aa) |
| | Ankrd52 | Ankyrin repeat domain 52. (1084 aa) |
| | Btbd11 | BTB (POZ) domain containing 11. (1109 aa) |
| | Trpc2 | Short transient receptor potential channel 2; Thought to form a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Is not activated by intracellular calcium store depletion. (1170 aa) |
| | Bcor | BCL6 co-repressor. (1757 aa) |
| | Rai14 | Ankycorbin; Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood- testis barrier. (978 aa) |
| | Git2 | G protein-coupled receptor kinase interacting ArfGAP 2. (759 aa) |
| | Kank2 | KN motif and ankyrin repeat domain-containing protein 2; Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in a [...] (847 aa) |
| | Anks1a | Ankyrin repeat and sterile alpha motif domain-containing 1A. (1125 aa) |
| | Ankrd37 | Ankyrin repeat domain 37. (159 aa) |
| | Ppp1r13l | Protein phosphatase 1, regulatory subunit 13-like. (825 aa) |
| | Ppp1r27 | Similar to protein phosphatase 1, regulatory subunit 12C; myosin-binding subunit 85 (Predicted). (154 aa) |
| | Ankrd35 | Ankyrin repeat domain 35. (990 aa) |
| | Ankrd34a | Ankyrin repeat domain-containing protein 34A. (495 aa) |
| | Camta2 | Calmodulin-binding transcription activator 2. (1202 aa) |
| | Ibtk | Inhibitor of Bruton tyrosine kinase. (1350 aa) |
| | LOC103690003 | ANK_REP_REGION domain-containing protein. (266 aa) |
| | Anks1b | Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. (1216 aa) |
| | Ankrd33b | Ankyrin repeat domain 33B. (481 aa) |
| | Trpv4 | Transient receptor potential cation channel subfamily V member 4; Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by heat, low pH, citrate and phorbol esters (By similarity). Increase of intracellular Ca(2+) potentiates currents (By similarity). Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (By similarity). Acts as a regulator of intracellular Ca(2+) i [...] (871 aa) |
| | Ankrd13a | Ankyrin repeat domain 13a. (589 aa) |
| | Anks6 | Ankyrin repeat and SAM domain-containing protein 6; Required for renal function. (779 aa) |
| | Ythdc2 | YTH domain-containing 2. (1276 aa) |
| | Asb15 | Ankyrin repeat and SOCS box-containing 15. (583 aa) |
| | RGD1565158 | ANK_REP_REGION domain-containing protein. (202 aa) |
| | Ankrd34b | Ankyrin repeat domain 34B. (508 aa) |
| | Nrarp | Notch-regulated ankyrin repeat protein. (114 aa) |
| | Camta1 | Calmodulin-binding transcription activator 1. (1609 aa) |
| | Ankrd65 | Ankyrin repeat domain 65. (365 aa) |
| | Asb3 | Ankyrin repeat and SOCS box-containing 3. (524 aa) |
| | Asb5 | Similar to ankyrin repeat and SOCs box-containing protein 5. (314 aa) |
| | Ankrd6 | Similar to ankyrin repeat domain 6. (713 aa) |
| | Kank4 | KN motif and ankyrin repeat domains 4. (1010 aa) |
| | Nudt12 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 12 (Predicted). (462 aa) |
| | Ankrd42 | Ankyrin repeat domain 42 (Predicted), isoform CRA_a. (521 aa) |
| | Ank1 | Ankyrin 1, erythroid. (1707 aa) |
| | D3Z908_RAT | Uncharacterized protein. (527 aa) |
| | Ankk1 | Ankyrin repeat and kinase domain-containing 1. (746 aa) |
| | Ankrd40 | Ankyrin repeat domain 40. (363 aa) |
| | Clip4 | CAP-Gly domain-containing linker protein 4. (598 aa) |
| | Ankrd29 | Ankyrin repeat domain-containing protein 29-like. (274 aa) |
| | Kidins220 | Kinase D-interacting substrate of 220 kDa; Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neuri [...] (1762 aa) |
| | Ankdd1a | Ankyrin repeat and death domain-containing 1A. (497 aa) |
| | Ankrd26 | Ankyrin repeat domain 26. (1675 aa) |
| | Asap3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (903 aa) |
| | Ankrd33 | Ankyrin repeat domain 33. (383 aa) |
| | Sowahd | Sosondowah ankyrin repeat domain family member D. (328 aa) |
