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Mical2 Mical2 Mical1 Mical1 Arhgef6 Arhgef6 Camsap3 Camsap3 Specc1l Specc1l Lrch4 Lrch4 LOC103693564 LOC103693564 Ccdc88c Ccdc88c Sptb Sptb Vav2 Vav2 Smtnl1 Smtnl1 Tagln2 Tagln2 Mapre3 Mapre3 Ehbp1 Ehbp1 Hook1 Hook1 Pls1 Pls1 Cnn3 Cnn3 Mapre1 Mapre1 Aspm Aspm Iqgap1 Iqgap1 Smtnl2 Smtnl2 Parva Parva Gas2 Gas2 Actn2 Actn2 Camsap1 Camsap1 Smtn Smtn Actn3 Actn3 Actn4 Actn4 Vav3 Vav3 Spef1 Spef1 Iqgap3 Iqgap3 Iqgap2 Iqgap2 Cnn1 Cnn1 Dmd Dmd Micall2 Micall2 Hook2 Hook2 Micall1 Micall1 Lrch2 Lrch2 Lrch3 Lrch3 Dst Dst Lrch1 Lrch1 Nav2 Nav2 Pls3 Pls3 Camsap2 Camsap2 Clmn Clmn LOC103691261 LOC103691261 Ccdc88b Ccdc88b Cnn2 Cnn2 Limch1 Limch1 Gas2l1 Gas2l1 Vav1 Vav1 Mapre2 Mapre2 M0R8A4_RAT M0R8A4_RAT Spata4 Spata4 Gas2l2 Gas2l2 Actn1 Actn1 Utrn Utrn Tagln Tagln Sptbn2 Sptbn2 Spef2 Spef2 Flnc Flnc Flnb Flnb A0A0G2JY25_RAT A0A0G2JY25_RAT Parvg Parvg Flna Flna Nav3 Nav3 Lcp1 Lcp1 Mical3 Mical3 Specc1 Specc1 Plec Plec Dixdc1 Dixdc1 Sptbn4 Sptbn4 Ehbp1l1 Ehbp1l1 Parvb Parvb Rasl10a Rasl10a Macf1 Macf1 Lmo7 Lmo7
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Mical2[F-actin]-monooxygenase MICAL2; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the n [...] (1103 aa)
Mical1[F-actin]-monooxygenase MICAL1; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation [...] (1047 aa)
Arhgef6Rho guanine nucleotide exchange factor 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF). (796 aa)
Camsap3Calmodulin-regulated spectrin-associated protein family, member 3. (1269 aa)
Specc1lCytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity). (1118 aa)
Lrch4Leucine-rich repeats and calponin homology domain-containing 4. (686 aa)
LOC103693564Transgelin-3. (199 aa)
Ccdc88cCoiled-coil domain-containing 88C. (2012 aa)
SptbSpectrin beta chain; Belongs to the spectrin family. (2329 aa)
Vav2Vav guanine nucleotide exchange factor 2. (868 aa)
Smtnl1Smoothelin-like 1. (470 aa)
Tagln2Transgelin-2; Belongs to the calponin family. (199 aa)
Mapre3Microtubule-associated protein RP/EB family member 3; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non- centrosomal minus-end microtubules to the Golgi, an important step for polarized [...] (281 aa)
Ehbp1EH domain-binding protein 1. (1205 aa)
Hook1Hook homolog 1 (Drosophila) (Predicted). (728 aa)
Pls1Plastin 1. (630 aa)
Cnn3Calponin-3; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (330 aa)
Mapre1Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, a [...] (268 aa)
AspmAbnormal spindle microtubule assembly. (3133 aa)
Iqgap1IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b. (1657 aa)
Smtnl2Smoothelin-like 2. (456 aa)
ParvaAlpha-parvin; Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and dire [...] (372 aa)
Gas2Similar to growth arrest-specific protein 2-mouse (Predicted), isoform CRA_b. (314 aa)
Actn2Actinin alpha 2. (894 aa)
Camsap1Calmodulin-regulated spectrin-associated protein 1; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (By similarity). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (By similarity). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without signi [...] (1604 aa)
SmtnRCG35999, isoform CRA_a. (921 aa)
Actn3Skeletal muscle-specific alpha-actinin 3. (900 aa)
Actn4Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcri [...] (911 aa)
Vav3Vav guanine nucleotide exchange factor 3. (847 aa)
Spef1RCG26209, isoform CRA_a. (233 aa)
Iqgap3IQ motif-containing GTPase-activating protein 3. (1632 aa)
Iqgap2IQ motif-containing GTPase-activating protein 2. (1425 aa)
Cnn1Calponin-1; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (297 aa)
DmdDystrophin; Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. (3677 aa)
Micall2MICAL-like protein 2; Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes [...] (1014 aa)
Hook2Hook microtubule-tethering protein 2. (719 aa)
Micall1MICAL-like protein 1; Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth. (855 aa)
Lrch2Leucine-rich repeats and calponin homology domain-containing 2. (772 aa)
Lrch3Leucine-rich repeats and calponin homology domain-containing 3. (769 aa)
DstDystonin. (7512 aa)
Lrch1Leucine-rich repeats and calponin homology domain-containing 1. (677 aa)
Nav2Neuron navigator 2. (2425 aa)
Pls3Plastin-3; Actin-bundling protein. (630 aa)
Camsap2Calmodulin-regulated spectrin-associated protein 2; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (By similarity). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (By similarity). In addition, it also red [...] (1470 aa)
ClmnCalmin. (1021 aa)
LOC103691261Sperm flagellar protein 1-like. (306 aa)
Ccdc88bCoiled-coil domain-containing 88B. (1476 aa)
Cnn2Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (219 aa)
Limch1LIM and calponin homology domains 1. (1085 aa)
Gas2l1Growth arrest-specific 2 like 1 (Predicted), isoform CRA_a. (428 aa)
Vav1Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. (843 aa)
Mapre2Microtubule-associated protein RP/EB family member 2; May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity); Belongs to the MAPRE family. (329 aa)
M0R8A4_RATUncharacterized protein. (247 aa)
Spata4Spermatogenesis-associated 4. (316 aa)
Gas2l2GAS2-like protein 2; Involved in the cross-linking of microtubules and microfilaments (By similarity). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (By similarity). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity); Belongs to the GAS2 family. (857 aa)
Actn1Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (914 aa)
UtrnUtrophin. (3424 aa)
TaglnTransgelin; Actin cross-linking/gelling protein. (207 aa)
Sptbn2Spectrin beta chain, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton. (2388 aa)
Spef2Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation. (1808 aa)
FlncFilamin-C; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. (2726 aa)
FlnbFilamin B. (2602 aa)
A0A0G2JY25_RATUncharacterized protein. (2070 aa)
ParvgParvin, gamma. (331 aa)
FlnaFilamin, alpha (Predicted), isoform CRA_a. (2639 aa)
Nav3Neuron navigator 3. (2254 aa)
Lcp1Lymphocyte cytosolic protein 1. (645 aa)
Mical3Microtubule-associated monooxygenase, calponin and LIM domain-containing 3. (1997 aa)
Specc1Sperm antigen with calponin homology and coiled-coil domains 1. (1153 aa)
PlecPlectin; Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics; Belongs to the plakin or cytolinker family. (4688 aa)
Dixdc1Dixin; Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2 (By similarity). (683 aa)
Sptbn4Spectrin beta chain; Belongs to the spectrin family. (2561 aa)
Ehbp1l1EH domain-binding protein 1-like 1. (1699 aa)
ParvbParvin, beta. (365 aa)
Rasl10aSimilar to RRP22 (Predicted), isoform CRA_a. (203 aa)
Macf1Microtubule-actin cross-linking factor 1; F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesion [...] (7384 aa)
Lmo7LIM domain 7. (1729 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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