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Alkbh3 Alkbh3 Alkbh5 Alkbh5 LOC100912458 LOC100912458 Alkbh1 Alkbh1 Alkbh4 Alkbh4 Alkbh7 Alkbh7 Alkbh2 Alkbh2 Fto Fto
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
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Alkbh3Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1- methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of [...] (295 aa)
Alkbh5RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...] (395 aa)
LOC100912458Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6. (238 aa)
Alkbh1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
Alkbh4AlkB, alkylation repair homolog 4 (E. coli) (Predicted), isoform CRA_a. (301 aa)
Alkbh7RCG45023, isoform CRA_a. (221 aa)
Alkbh2AlkB homolog 2, alpha-ketoglutarate-dependent dioxygenase. (287 aa)
FtoAlpha-ketoglutarate-dependent dioxygenase FTO; RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating th [...] (512 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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