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Plxna4 | Plexin A4. (1893 aa) | ||||
Plxna2 | Plexin A2. (1894 aa) | ||||
Plxna1 | Plexin A1. (1912 aa) | ||||
Plxnd1 | Plexin D1 (Predicted). (1716 aa) | ||||
Plxnb1 | Plexin B1. (2121 aa) | ||||
Plxna3 | Plexin-A3; Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for s [...] (1872 aa) | ||||
Plxnb3 | Plexin-B3; Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA- mediated inactivation of RAC1; Belongs to the plexin family. (1902 aa) |