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Mtmr6 Mtmr6 Mtmr3 Mtmr3 Mtmr7 Mtmr7 Mtmr1 Mtmr1 Sbf1 Sbf1 Mtm1 Mtm1 Mtmr11 Mtmr11 Mtmr12 Mtmr12 Mtmr10 Mtmr10 Mtmr9 Mtmr9 Sbf2 Sbf2 Mtmr4 Mtmr4 Mtmr2 Mtmr2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Mtmr6Myotubularin-related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (By similarity). Negatively regulates ER-Golgi protein transport. Probably in association with MTMR9, plays [...] (655 aa)
Mtmr3Myotubularin-related protein 3; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3- phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity). (1207 aa)
Mtmr7Myotubularin-related protein 7. (660 aa)
Mtmr1Myotubularin-related protein 1. (672 aa)
Sbf1SET-binding factor 1. (1893 aa)
Mtm1Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not fo [...] (554 aa)
Mtmr11Myotubularin-related protein 11. (700 aa)
Mtmr12Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. (748 aa)
Mtmr10Myotubularin-related protein 10. (771 aa)
Mtmr9Myotubularin-related protein 9. (549 aa)
Sbf2SET-binding factor 2. (1826 aa)
Mtmr4Myotubularin-related protein 4. (1191 aa)
Mtmr2Myotubularin related protein 2 (Predicted), isoform CRA_b. (643 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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