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Pdgfa Pdgfa Col10a1 Col10a1 Lama5 Lama5 Col4a6 Col4a6 Itga5 Itga5 Col2a1 Col2a1 LOC100909752 LOC100909752 Col14a1 Col14a1 Col16a1 Col16a1 Col4a5 Col4a5 Col8a1 Col8a1 Col4a2 Col4a2 Col4a1 Col4a1 Col18a1 Col18a1 Col4a4 Col4a4 Itga3 Itga3 Col22a1 Col22a1 Pten Pten Col7a1 Col7a1 Col5a3 Col5a3 Pdgfb Pdgfb Itga8 Itga8 Col4a3 Col4a3 Col15a1 Col15a1 Col1a2 Col1a2 Pdgfc Pdgfc Col5a1 Col5a1 Col27a1 Col27a1 Cd44 Cd44 Dcn Dcn Col1a1 Col1a1 Col5a2 Col5a2 Col3a1 Col3a1 Alb Alb Nid1 Nid1 Itga6 Itga6 Col6a2 Col6a2 Col6a1 Col6a1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PdgfaPlatelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by t [...] (211 aa)
Col10a1Collagen type X alpha 1 chain. (680 aa)
Lama5Laminin, alpha 5, isoform CRA_a. (3713 aa)
Col4a6Collagen type IV alpha 6 chain. (1638 aa)
Itga5Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. (1099 aa)
Col2a1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1419 aa)
LOC100909752Procollagen, type XV, isoform CRA_a. (1345 aa)
Col14a1Collagen type XIV alpha 1 chain. (1794 aa)
Col16a1Collagen type XVI alpha 1 chain. (1618 aa)
Col4a5Collagen type IV alpha 5 chain. (1691 aa)
Col8a1Collagen type VIII alpha 1 chain. (744 aa)
Col4a2Collagen type IV alpha 2 chain. (1645 aa)
Col4a1Collagen type IV alpha 1 chain. (1669 aa)
Col18a1Procollagen, type XVIII, alpha 1, isoform CRA_a. (1311 aa)
Col4a4Collagen type IV alpha 4 chain. (159 aa)
Itga3Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. (1067 aa)
Col22a1Collagen type XXII alpha 1 chain. (1613 aa)
PtenPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. (403 aa)
Col7a1Procollagen, type VII, alpha 1 (Predicted). (2588 aa)
Col5a3Procollagen, type V, alpha 3, isoform CRA_b. (1737 aa)
PdgfbPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (241 aa)
Itga8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
Col4a3Collagen type IV alpha 3 chain. (1671 aa)
Col15a1Collagen alpha-1(XV) chain-like. (1312 aa)
Col1a2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1372 aa)
PdgfcPlatelet-derived growth factor C, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in [...] (345 aa)
Col5a1Collagen alpha-1(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (By similarity). (1840 aa)
Col27a1Collagen alpha-1(XXVII) chain; Plays a role during the calcification of cartilage and the transition of cartilage to bone. (1855 aa)
Cd44CD44 antigen. (779 aa)
DcnDecorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix. (354 aa)
Col1a1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1453 aa)
Col5a2Collagen type V alpha 2 chain. (1494 aa)
Col3a1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity). (1463 aa)
AlbSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
Nid1Nidogen-1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. (1246 aa)
Itga6Integrin, alpha 6, isoform CRA_a; Belongs to the integrin alpha chain family. (1073 aa)
Col6a2Procollagen, type VI, alpha 2, isoform CRA_a. (1027 aa)
Col6a1Collagen type VI alpha 1 chain. (1025 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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