STRINGSTRING
Rpl39 Rpl39 Chek2 Chek2 Exo1 Exo1 Smc5 Smc5 Sirt1 Sirt1 Smc6 Smc6 Rad50 Rad50 Ube2v2 Ube2v2 Glrx2 Glrx2 LOC103690821-6 LOC103690821-6 Kat2a Kat2a LOC103690821-5 LOC103690821-5 LOC103690821-4 LOC103690821-4 LOC103690821-3 LOC103690821-3 LOC103690821-2 LOC103690821-2 LOC103690821 LOC103690821 Mus81 Mus81 Ubr1 Ubr1 Rad52 Rad52 Cwc25 Cwc25 Tsr2 Tsr2 Slc25a16 Slc25a16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rpl3960S ribosomal protein L39. (51 aa)
Chek2CHK2 checkpoint homolog (S. pombe), isoform CRA_a. (545 aa)
Exo1Exonuclease 1. (836 aa)
Smc5Structural maintenance of chromosomes 5. (1102 aa)
Sirt1NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expres [...] (730 aa)
Smc6SMC6 structural maintenance of chromosomes 6-like 1 (Yeast) (Predicted). (1097 aa)
Rad50DNA repair protein RAD50; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease [...] (1312 aa)
Ube2v2Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage; Belongs to the ubiquitin-conjugating enzym [...] (145 aa)
Glrx2Glutaredoxin-2, mitochondrial; Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylat [...] (157 aa)
LOC103690821-660S ribosomal protein L39. (51 aa)
Kat2aHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
LOC103690821-5Ribosomal protein L39. (51 aa)
LOC103690821-460S ribosomal protein L39. (51 aa)
LOC103690821-360S ribosomal protein L39. (51 aa)
LOC103690821-260S ribosomal protein L39. (51 aa)
LOC10369082160S ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
Mus81Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. (551 aa)
Ubr1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1329 aa)
Rad52RAD52 homolog, DNA repair protein. (426 aa)
Cwc25CWC25 spliceosome-associated protein homolog. (415 aa)
Tsr2TSR2, ribosome maturation factor. (192 aa)
Slc25a16DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavag [...] (1215 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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