node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adamts2 | Col2a1 | ENSRNOP00000075206 | ENSRNOP00000071077 | ADAM metallopeptidase with thrombospondin type 1 motif, 2. | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | 0.573 |
Adamts2 | Crtap | ENSRNOP00000075206 | ENSRNOP00000064550 | ADAM metallopeptidase with thrombospondin type 1 motif, 2. | Similar to Cartilage-associated protein (Predicted), isoform CRA_a. | 0.414 |
Adamts2 | LOC102555086 | ENSRNOP00000075206 | ENSRNOP00000068391 | ADAM metallopeptidase with thrombospondin type 1 motif, 2. | Similar to Cartilage-associated protein (Predicted), isoform CRA_b. | 0.414 |
Adamts2 | Lox | ENSRNOP00000075206 | ENSRNOP00000065314 | ADAM metallopeptidase with thrombospondin type 1 motif, 2. | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. | 0.539 |
Adamts2 | Plod1 | ENSRNOP00000075206 | ENSRNOP00000010433 | ADAM metallopeptidase with thrombospondin type 1 motif, 2. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity). | 0.504 |
Adamts2 | Vwf | ENSRNOP00000075206 | ENSRNOP00000026643 | ADAM metallopeptidase with thrombospondin type 1 motif, 2. | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). | 0.436 |
Col2a1 | Adamts2 | ENSRNOP00000071077 | ENSRNOP00000075206 | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | ADAM metallopeptidase with thrombospondin type 1 motif, 2. | 0.573 |
Col2a1 | LOC102555086 | ENSRNOP00000071077 | ENSRNOP00000068391 | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | Similar to Cartilage-associated protein (Predicted), isoform CRA_b. | 0.621 |
Col2a1 | P3h1 | ENSRNOP00000071077 | ENSRNOP00000071755 | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity). | 0.617 |
Col2a1 | P3h2 | ENSRNOP00000071077 | ENSRNOP00000074673 | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens. Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position (By similarity). Belongs to the leprecan family. | 0.637 |
Col2a1 | Plod1 | ENSRNOP00000071077 | ENSRNOP00000010433 | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity). | 0.599 |
Col2a1 | Plod2 | ENSRNOP00000071077 | ENSRNOP00000053546 | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. | 0.636 |
Crtap | Adamts2 | ENSRNOP00000064550 | ENSRNOP00000075206 | Similar to Cartilage-associated protein (Predicted), isoform CRA_a. | ADAM metallopeptidase with thrombospondin type 1 motif, 2. | 0.414 |
Crtap | P3h1 | ENSRNOP00000064550 | ENSRNOP00000071755 | Similar to Cartilage-associated protein (Predicted), isoform CRA_a. | Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity). | 0.965 |
Crtap | P3h2 | ENSRNOP00000064550 | ENSRNOP00000074673 | Similar to Cartilage-associated protein (Predicted), isoform CRA_a. | Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens. Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position (By similarity). Belongs to the leprecan family. | 0.411 |
Crtap | Plod1 | ENSRNOP00000064550 | ENSRNOP00000010433 | Similar to Cartilage-associated protein (Predicted), isoform CRA_a. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity). | 0.580 |
Crtap | Plod2 | ENSRNOP00000064550 | ENSRNOP00000053546 | Similar to Cartilage-associated protein (Predicted), isoform CRA_a. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. | 0.615 |
LOC102555086 | Adamts2 | ENSRNOP00000068391 | ENSRNOP00000075206 | Similar to Cartilage-associated protein (Predicted), isoform CRA_b. | ADAM metallopeptidase with thrombospondin type 1 motif, 2. | 0.414 |
LOC102555086 | Col2a1 | ENSRNOP00000068391 | ENSRNOP00000071077 | Similar to Cartilage-associated protein (Predicted), isoform CRA_b. | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | 0.621 |
LOC102555086 | P3h1 | ENSRNOP00000068391 | ENSRNOP00000071755 | Similar to Cartilage-associated protein (Predicted), isoform CRA_b. | Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity). | 0.992 |