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D4A7L5_RAT D4A7L5_RAT Ube2a Ube2a Trim63 Trim63 Hist3h2ba Hist3h2ba Ube2v2 Ube2v2 Rad18 Rad18 Ube2h Ube2h M0R538_RAT M0R538_RAT LOC684444 LOC684444 H2bu1 H2bu1 Ctnnb1 Ctnnb1 Hist1h2bd Hist1h2bd Mdm2 Mdm2 H2bc12 H2bc12 LOC102549061 LOC102549061 Hist1h2bo Hist1h2bo H2bc9 H2bc9 Ube2n Ube2n Brca1 Brca1 Igf1 Igf1 Tp53 Tp53 Hist1h2bf Hist1h2bf Ube2j2 Ube2j2 Trim27 Trim27 Ube2g2 Ube2g2 Traf6 Traf6 Ube2e3 Ube2e3 Ube2t Ube2t Fbxo32 Fbxo32 Ube2e1 Ube2e1 Magel2 Magel2 Ube2g1 Ube2g1 Trim32 Trim32 Lalba Lalba Ube2o Ube2o Ube2r2 Ube2r2 Ins1 Ins1 Ube2c Ube2c Ubr2 Ubr2 H2bc1 H2bc1 Rnf25 Rnf25 Ube2s Ube2s Ube2i Ube2i Ins2 Ins2 Ube2q1 Ube2q1 Hist1h2bc Hist1h2bc Pcna Pcna Ube2u Ube2u Trim72 Trim72 Ube2k Ube2k Ube2j1 Ube2j1 Hist2h2be Hist2h2be Sumo4 Sumo4 Ube2e2 Ube2e2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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D4A7L5_RATSmall ubiquitin-related modifier. (108 aa)
Ube2aUbiquitin-conjugating enzyme E2A, RAD6 homolog (S. cerevisiae); Belongs to the ubiquitin-conjugating enzyme family. (162 aa)
Trim63E3 ubiquitin-protein ligase TRIM63; E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-h [...] (351 aa)
Hist3h2baHistone H2B; Belongs to the histone H2B family. (126 aa)
Ube2v2Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage; Belongs to the ubiquitin-conjugating enzym [...] (145 aa)
Rad18RAD18 E3 ubiquitin protein ligase. (494 aa)
Ube2hUbiquitin-conjugating enzyme E2H; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
M0R538_RATHistone domain-containing protein; Belongs to the histone H2B family. (122 aa)
LOC684444Similar to HIStone family member (his-41); Belongs to the histone H2B family. (123 aa)
H2bu1Histone H2B; Belongs to the histone H2B family. (126 aa)
Ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] (781 aa)
Hist1h2bdHistone H2B; Belongs to the histone H2B family. (126 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (483 aa)
H2bc12Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC102549061Histone H2B; Belongs to the histone H2B family. (126 aa)
Hist1h2boHistone H2B; Belongs to the histone H2B family. (138 aa)
H2bc9Histone H2B; Belongs to the histone H2B family. (126 aa)
Ube2nUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
Brca1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1817 aa)
Igf1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (159 aa)
Tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
Hist1h2bfHistone H2B; Belongs to the histone H2B family. (126 aa)
Ube2j2Similar to Ubc6p homolog, isoform CRA_a. (271 aa)
Trim27Tripartite motif protein 27 (Predicted), isoform CRA_b. (513 aa)
Ube2g2Ubiquitin-conjugating enzyme E2G 2 (Predicted), isoform CRA_b; Belongs to the ubiquitin-conjugating enzyme family. (165 aa)
Traf6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (530 aa)
Ube2e3Ubiquitin-conjugating enzyme E2E 3; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
Ube2tUbiquitin-conjugating enzyme E2T (Putative) (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family. (204 aa)
Fbxo32F-box only protein 32; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity). (350 aa)
Ube2e1Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (173 aa)
Magel2MAGE family member L2. (1258 aa)
Ube2g1Ubiquitin-conjugating enzyme E2 G1, N-terminally processed; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
Trim32Tripartite motif-containing 32. (655 aa)
LalbaAlpha-lactalbumin; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N- acetylglucosamine of the oligosaccharide chains in glycoproteins; Belongs to the glycosyl hydrolase 22 family. (159 aa)
Ube2oUbiquitin-conjugating enzyme E2O. (1138 aa)
Ube2r2Ubiquitin-conjugating enzyme E2R 2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
Ins1Insulin-1 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
Ube2cUbiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
Ubr2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
H2bc1Histone H2B type 1-A; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large- scale exchange of histones. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcrip [...] (127 aa)
Rnf25Ring finger protein 25. (454 aa)
Ube2sUbiquitin-conjugating enzyme E2 S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiqui [...] (223 aa)
Ube2iSUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451 (By similarity). Can catalyze the formation of poly-SUMO chains (By similarity). Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386' (By similarity). Mediates sumoylation of ERCC6 which is essential for its transcription-coupled [...] (158 aa)
Ins2Insulin-2 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
Ube2q1Ubiquitin-conjugating enzyme E2Q (Putative) (Predicted), isoform CRA_a. (422 aa)
Hist1h2bcHistone H2B type 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
PcnaProliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] (261 aa)
Ube2uUbiquitin-conjugating enzyme E2 U. (337 aa)
Trim72Tripartite motif-containing protein 72; Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)- depen [...] (477 aa)
Ube2kHuntingtin interacting protein 2 (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
Ube2j1Ubiquitin-conjugating enzyme E2, J1. (248 aa)
Hist2h2beHistone H2B; Belongs to the histone H2B family. (126 aa)
Sumo4Small ubiquitin-related modifier. (95 aa)
Ube2e2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (126 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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