STRINGSTRING
Foxp2 Foxp2 Pxdn Pxdn Satb2 Satb2 Tle4 Tle4 Cux2 Cux2 Prdm8 Prdm8 Bcl11b Bcl11b Btbd3 Btbd3 Fezf2 Fezf2 Zic1 Zic1 Prl Prl Gad2 Gad2 Cux1 Cux1 Reln Reln Tbr1 Tbr1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Foxp2Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays a role in synapse formation by regulating SRPX2 levels. (710 aa)
PxdnPeroxidasin. (1475 aa)
Satb2DNA-binding protein SATB. (733 aa)
Tle4Transducin-like enhancer protein 4; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity); Belongs to the WD repeat Groucho/TLE family. (763 aa)
Cux2Homeobox protein cut-like. (1426 aa)
Prdm8PR/SET domain 8. (689 aa)
Bcl11bBAF chromatin-remodeling complex subunit BCL11B. (921 aa)
Btbd3BTB (POZ) domain containing 3 (Predicted). (528 aa)
Fezf2Zinc finger protein 312 (Predicted). (455 aa)
Zic1Zinc finger protein of the cerebellum 1, isoform CRA_a. (447 aa)
PrlProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (226 aa)
Gad2Glutamate decarboxylase 2; Catalyzes the production of GABA. (585 aa)
Cux1Homeobox protein cut-like 1; Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity). Binds to the TH enhancer; may require the basic helix-loop-helix protein T [...] (1504 aa)
RelnReelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity). (3462 aa)
Tbr1T-box brain transcription factor 1. (680 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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