STRINGSTRING
RGD1564548 RGD1564548 H3c1-4 H3c1-4 Fto Fto RGD1564447 RGD1564447 Setdb1 Setdb1 Smc5 Smc5 Atrx Atrx Smc6 Smc6 M0RBX6_RAT M0RBX6_RAT H3c1 H3c1 H3f3c H3f3c Ythdf3 Ythdf3 Ythdc2 Ythdc2 Relb Relb Hdac5 Hdac5 Atrx-2 Atrx-2 LOC684762 LOC684762 Rela Rela Ythdf1 Ythdf1 Alkbh5 Alkbh5 Sp100 Sp100 Ddb1 Ddb1 Irf3 Irf3 Wtap Wtap Nsun2 Nsun2 Mettl14 Mettl14 Kmt2a Kmt2a Ifitm2 Ifitm2 Ythdf2 Ythdf2 Ftsj3 Ftsj3 Nat10 Nat10 Tbk1 Tbk1 Ifnb1 Ifnb1 Hdac9 Hdac9 LOC100361558 LOC100361558 Ythdc1 Ythdc1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RGD1564548Similar to H3 histone, family 3B. (136 aa)
H3c1-4Histone cluster 1 H2a family member I like 1. (136 aa)
FtoAlpha-ketoglutarate-dependent dioxygenase FTO; RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating th [...] (512 aa)
RGD1564447Histone H3; Belongs to the histone H3 family. (136 aa)
Setdb1SET domain bifurcated histone lysine methyltransferase 1. (1322 aa)
Smc5Structural maintenance of chromosomes 5. (1102 aa)
AtrxTranscriptional regulator ATRX; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase a [...] (2475 aa)
Smc6SMC6 structural maintenance of chromosomes 6-like 1 (Yeast) (Predicted). (1097 aa)
M0RBX6_RATHistone H3; Belongs to the histone H3 family. (136 aa)
H3c1Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
H3f3cHistone H3; Belongs to the histone H3 family. (136 aa)
Ythdf3YTH N(6)-methyladenosine RNA-binding protein 3. (585 aa)
Ythdc2YTH domain-containing 2. (1276 aa)
RelbRELB proto-oncogene, NF-kB subunit. (558 aa)
Hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (947 aa)
Atrx-2Transcriptional regulator ATRX. (157 aa)
LOC684762Histone H3; Belongs to the histone H3 family. (136 aa)
RelaV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (550 aa)
Ythdf1YTH N(6)-methyladenosine RNA-binding protein 1. (559 aa)
Alkbh5RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...] (395 aa)
Sp100SP100 nuclear antigen. (338 aa)
Ddb1DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] (1140 aa)
Irf3Interferon regulatory factor 3, isoform CRA_c. (421 aa)
WtapWT1-associated protein. (395 aa)
Nsun2NOL1/NOP2/Sun domain family, member 2 (Predicted); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (782 aa)
Mettl14Similar to KIAA1627 protein (Predicted), isoform CRA_b; Belongs to the MT-A70-like family. (456 aa)
Kmt2aHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3843 aa)
Ifitm2Interferon-induced transmembrane protein 2. (144 aa)
Ythdf2YTH N(6)-methyladenosine RNA-binding protein 2. (585 aa)
Ftsj3pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. (829 aa)
Nat10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1024 aa)
Tbk1Similar to TANK-binding kinase 1. (729 aa)
Ifnb1Interferon beta; Has antiviral, antibacterial and anticancer activities; Belongs to the alpha/beta interferon family. (184 aa)
Hdac9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1068 aa)
LOC100361558Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
Ythdc1YTH domain-containing protein 1; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs, and acts as a regulator of alternative splicing. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (By similarity). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjac [...] (738 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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