STRINGSTRING
Col6a4 Col6a4 Col6a1 Col6a1 Col6a2 Col6a2 Col3a1 Col3a1 Col5a2 Col5a2 Col1a1 Col1a1 Col10a1 Col10a1 Col4a6 Col4a6 Bgn Bgn Col2a1 Col2a1 Col6a5 Col6a5 Col11a1 Col11a1 Col4a5 Col4a5 Col4a2 Col4a2 Col4a1 Col4a1 Col6a6 Col6a6 Col9a2 Col9a2 Col4a4 Col4a4 Col4a3 Col4a3 Col9a1 Col9a1 Col1a2 Col1a2 Col9a3 Col9a3 Col5a1 Col5a1 Mmp13 Mmp13 Dcn Dcn
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Col6a4Collagen, type VI, alpha 4. (2113 aa)
Col6a1Collagen type VI alpha 1 chain. (1025 aa)
Col6a2Procollagen, type VI, alpha 2, isoform CRA_a. (1027 aa)
Col3a1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity). (1463 aa)
Col5a2Collagen type V alpha 2 chain. (1494 aa)
Col1a1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1453 aa)
Col10a1Collagen type X alpha 1 chain. (680 aa)
Col4a6Collagen type IV alpha 6 chain. (1638 aa)
BgnBiglycan; May be involved in collagen fiber assembly. (369 aa)
Col2a1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1419 aa)
Col6a5Collagen type VI alpha 5 chain. (2632 aa)
Col11a1Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. (1804 aa)
Col4a5Collagen type IV alpha 5 chain. (1691 aa)
Col4a2Collagen type IV alpha 2 chain. (1645 aa)
Col4a1Collagen type IV alpha 1 chain. (1669 aa)
Col6a6Collagen type VI alpha 6 chain. (2264 aa)
Col9a2Procollagen, type IX, alpha 2 (Predicted). (688 aa)
Col4a4Collagen type IV alpha 4 chain. (159 aa)
Col4a3Collagen type IV alpha 3 chain. (1671 aa)
Col9a1Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. (934 aa)
Col1a2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1372 aa)
Col9a3Collagen type IX alpha 3 chain. (680 aa)
Col5a1Collagen alpha-1(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (By similarity). (1840 aa)
Mmp13Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] (472 aa)
DcnDecorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix. (354 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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