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M0R660_RAT M0R660_RAT Hnrnpc Hnrnpc Igf2bp3 Igf2bp3 LOC303448 LOC303448 A0A0G2K7M1_RAT A0A0G2K7M1_RAT RGD1564958 RGD1564958 Gapdh Gapdh Ythdc1 Ythdc1 Mettl16 Mettl16 Slc26a3 Slc26a3 Ythdf2 Ythdf2 Hnrnpa2b1 Hnrnpa2b1 Zc3h13 Zc3h13 Ins1 Ins1 Mettl14 Mettl14 Wtap Wtap Ins2 Ins2 Mettl4 Mettl4 Alkbh5 Alkbh5 Igf2bp2 Igf2bp2 Ythdf1 Ythdf1 E9PTV9_RAT E9PTV9_RAT D3ZWV2_RAT D3ZWV2_RAT D3ZGY4_RAT D3ZGY4_RAT E9PTN6_RAT E9PTN6_RAT Ythdc2 Ythdc2 LOC100911576 LOC100911576 Virma Virma Ythdf3 Ythdf3 Rbm15 Rbm15 LOC108351137 LOC108351137
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
M0R660_RATGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
HnrnpcHeterogeneous nuclear ribonucleoprotein C, isoform CRA_a. (313 aa)
Igf2bp3Insulin-like growth factor 2 mRNA-binding protein 3. (579 aa)
LOC303448Similar to glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
A0A0G2K7M1_RATGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
RGD1564958Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
GapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
Ythdc1YTH domain-containing protein 1; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs, and acts as a regulator of alternative splicing. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (By similarity). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjac [...] (738 aa)
Mettl16U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (553 aa)
Slc26a3Chloride anion exchanger; Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity). Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (757 aa)
Ythdf2YTH N(6)-methyladenosine RNA-binding protein 2. (585 aa)
Hnrnpa2b1Heterogeneous nuclear ribonucleoproteins A2/B1; Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and he [...] (352 aa)
Zc3h13Zinc finger CCCH type-containing 13. (1728 aa)
Ins1Insulin-1 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
Mettl14Similar to KIAA1627 protein (Predicted), isoform CRA_b; Belongs to the MT-A70-like family. (456 aa)
WtapWT1-associated protein. (395 aa)
Ins2Insulin-2 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
Mettl4Methyltransferase-like 4; Belongs to the MT-A70-like family. (471 aa)
Alkbh5RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...] (395 aa)
Igf2bp2Similar to IGF-II mRNA-binding protein 2 (Predicted). (592 aa)
Ythdf1YTH N(6)-methyladenosine RNA-binding protein 1. (559 aa)
E9PTV9_RATGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
D3ZWV2_RATGlyceraldehyde-3-phosphate dehydrogenase. (325 aa)
D3ZGY4_RATGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
E9PTN6_RATGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
Ythdc2YTH domain-containing 2. (1276 aa)
LOC100911576Heterogeneous nuclear ribonucleoprotein C; Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilit [...] (300 aa)
VirmaVir-like m6A methyltransferase-associated. (1811 aa)
Ythdf3YTH N(6)-methyladenosine RNA-binding protein 3. (585 aa)
Rbm15RNA-binding motif protein 15. (962 aa)
LOC108351137Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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