STRINGSTRING
Ass1 Ass1 Ccnb1 Ccnb1 RGD1564548 RGD1564548 Hist1h2bf Hist1h2bf RGD1564447 RGD1564447 H2bc9 H2bc9 Hist1h2bo Hist1h2bo LOC102549061 LOC102549061 H2bc12 H2bc12 Hltf Hltf Hist1h2bd Hist1h2bd M0RBX6_RAT M0RBX6_RAT H2bu1 H2bu1 LOC684444 LOC684444 M0R538_RAT M0R538_RAT H3c1 H3c1 Rad18 Rad18 Hist3h2ba Hist3h2ba H3f3c H3f3c Slbp Slbp LOC684762 LOC684762 Hist2h2be Hist2h2be Ccna1 Ccna1 Hist2h4 Hist2h4 Pcna Pcna Hist1h2bc Hist1h2bc Lmna Lmna H2bc1 H2bc1 Smarcal1 Smarcal1 Ccna2 Ccna2 Shprh Shprh Lig1 Lig1 Cd44 Cd44 Brd4 Brd4 Zranb3 Zranb3 LOC100361558 LOC100361558 Rfc2 Rfc2 Rfc5 Rfc5 Slc25a16 Slc25a16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ass1Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. (412 aa)
Ccnb1G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. (423 aa)
RGD1564548Similar to H3 histone, family 3B. (136 aa)
Hist1h2bfHistone H2B; Belongs to the histone H2B family. (126 aa)
RGD1564447Histone H3; Belongs to the histone H3 family. (136 aa)
H2bc9Histone H2B; Belongs to the histone H2B family. (126 aa)
Hist1h2boHistone H2B; Belongs to the histone H2B family. (138 aa)
LOC102549061Histone H2B; Belongs to the histone H2B family. (126 aa)
H2bc12Histone H2B; Belongs to the histone H2B family. (126 aa)
HltfHelicase-like transcription factor. (1003 aa)
Hist1h2bdHistone H2B; Belongs to the histone H2B family. (126 aa)
M0RBX6_RATHistone H3; Belongs to the histone H3 family. (136 aa)
H2bu1Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC684444Similar to HIStone family member (his-41); Belongs to the histone H2B family. (123 aa)
M0R538_RATHistone domain-containing protein; Belongs to the histone H2B family. (122 aa)
H3c1Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
Rad18RAD18 E3 ubiquitin protein ligase. (494 aa)
Hist3h2baHistone H2B; Belongs to the histone H2B family. (126 aa)
H3f3cHistone H3; Belongs to the histone H3 family. (136 aa)
SlbpStem-loop-binding protein. (275 aa)
LOC684762Histone H3; Belongs to the histone H3 family. (136 aa)
Hist2h2beHistone H2B; Belongs to the histone H2B family. (126 aa)
Ccna1Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells (By similarity). Belongs to the cyclin family. Cyclin AB subfamily. (421 aa)
Hist2h4Osteogenic growth peptide; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
PcnaProliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] (261 aa)
Hist1h2bcHistone H2B type 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
LmnaPrelamin-A/C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. A [...] (665 aa)
H2bc1Histone H2B type 1-A; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large- scale exchange of histones. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcrip [...] (127 aa)
Smarcal1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks ( [...] (910 aa)
Ccna2Cyclin A2, isoform CRA_b. (418 aa)
ShprhSNF2 histone linker PHD RING helicase (Predicted). (1701 aa)
Lig1DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (913 aa)
Cd44CD44 antigen. (779 aa)
Brd4Bromodomain-containing 4. (1403 aa)
Zranb3Zinc finger RANBP2-type-containing 3. (1072 aa)
LOC100361558Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
Rfc2Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). (349 aa)
Rfc5Replication factor C (Activator 1) 5 (Predicted). (338 aa)
Slc25a16DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavag [...] (1215 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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