STRINGSTRING
Tmprss6 Tmprss6 Col3a1 Col3a1 Col5a2 Col5a2 Col1a1 Col1a1 Mmp13 Mmp13 Mmp12 Mmp12 Mmp3 Mmp3 Col5a1 Col5a1 Mmp1 Mmp1 Mmp10 Mmp10 Mmp8 Mmp8 Mmp7 Mmp7 Ctsb Ctsb Col8a2 Col8a2 Furin Furin Col1a2 Col1a2 Col19a1 Col19a1 Mmp15 Mmp15 Prss2 Prss2 Mmp2 Mmp2 Mmp9 Mmp9 Ctsl Ctsl Ctsd Ctsd Col5a3 Col5a3 Col7a1 Col7a1 Ctsk Ctsk Mmp20 Mmp20 Try5 Try5 LOC103690164 LOC103690164 Try4 Try4 Prss1 Prss1 LOC683849 LOC683849 LOC102554637 LOC102554637 Col18a1 Col18a1 Try10 Try10 Col11a2 Col11a2 Col4a1 Col4a1 Col4a2 Col4a2 Col26a1 Col26a1 Col8a1 Col8a1 Col4a5 Col4a5 Col11a1 Col11a1 Col25a1 Col25a1 Mmp14 Mmp14 LOC100909752 LOC100909752 Col2a1 Col2a1 Col13a1 Col13a1 Col4a6 Col4a6 Col10a1 Col10a1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tmprss6Transmembrane serine protease 6 (Predicted), isoform CRA_a; Belongs to the peptidase S1 family. (772 aa)
Col3a1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity). (1463 aa)
Col5a2Collagen type V alpha 2 chain. (1494 aa)
Col1a1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1453 aa)
Mmp13Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] (472 aa)
Mmp12Macrophage metalloelastase; May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity). Belongs to the peptidase M10A family. (477 aa)
Mmp3Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (473 aa)
Col5a1Collagen alpha-1(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (By similarity). (1840 aa)
Mmp1Interstitial collagenase. (464 aa)
Mmp10Stromelysin-2; Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase; Belongs to the peptidase M10A family. (476 aa)
Mmp8Neutrophil collagenase; Can degrade fibrillar type I, II, and III collagens. (466 aa)
Mmp7Matrilysin; Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase (By similarity); Belongs to the peptidase M10A family. (267 aa)
CtsbCathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. (339 aa)
Col8a2Collagen type VIII alpha 2 chain. (699 aa)
FurinFurin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. (793 aa)
Col1a2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1372 aa)
Col19a1Collagen type XIX alpha 1 chain. (1129 aa)
Mmp15Matrix metallopeptidase 15. (657 aa)
Prss2Anionic trypsin-2; Belongs to the peptidase S1 family. (246 aa)
Mmp272 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...] (663 aa)
Mmp9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). Belongs to the peptidase M10A family. (708 aa)
CtslCathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (334 aa)
CtsdCathepsin D 12 kDa light chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. (407 aa)
Col5a3Procollagen, type V, alpha 3, isoform CRA_b. (1737 aa)
Col7a1Procollagen, type VII, alpha 1 (Predicted). (2588 aa)
CtskCathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. (329 aa)
Mmp20Matrix metalloproteinase 20 (Enamelysin) (Predicted). (482 aa)
Try5Trypsin 5; Belongs to the peptidase S1 family. (246 aa)
LOC1036901645-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (476 aa)
Try4Serine protease 3; Belongs to the peptidase S1 family. (246 aa)
Prss1Anionic trypsin-1; Belongs to the peptidase S1 family. (246 aa)
LOC683849Similar to Anionic trypsin II precursor (Pretrypsinogen II); Belongs to the peptidase S1 family. (246 aa)
LOC102554637Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
Col18a1Procollagen, type XVIII, alpha 1, isoform CRA_a. (1311 aa)
Try10Trypsin 10; Belongs to the peptidase S1 family. (246 aa)
Col11a2Procollagen, type XI, alpha 2 (Mapped). (1650 aa)
Col4a1Collagen type IV alpha 1 chain. (1669 aa)
Col4a2Collagen type IV alpha 2 chain. (1645 aa)
Col26a1Collagen type XXVI alpha 1 chain. (440 aa)
Col8a1Collagen type VIII alpha 1 chain. (744 aa)
Col4a5Collagen type IV alpha 5 chain. (1691 aa)
Col11a1Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. (1804 aa)
Col25a1Collagen type XXV alpha 1 chain. (503 aa)
Mmp14Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which in [...] (582 aa)
LOC100909752Procollagen, type XV, isoform CRA_a. (1345 aa)
Col2a1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1419 aa)
Col13a1Similar to alpha 1 type XIII collagen isoform 17, isoform CRA_a. (739 aa)
Col4a6Collagen type IV alpha 6 chain. (1638 aa)
Col10a1Collagen type X alpha 1 chain. (680 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.