STRINGSTRING
Col6a2 Col6a2 Plod3 Plod3 Col3a1 Col3a1 Col5a2 Col5a2 Col1a1 Col1a1 Col27a1 Col27a1 Plod1 Plod1 Col5a1 Col5a1 Col9a3 Col9a3 Col8a2 Col8a2 Col1a2 Col1a2 Col19a1 Col19a1 Tll2 Tll2 Col24a1 Col24a1 P3h3 P3h3 Ppib Ppib Serpinh1 Serpinh1 Colgalt1 Colgalt1 Col5a3 Col5a3 Col7a1 Col7a1 Col22a1 Col22a1 Colgalt2 Colgalt2 Bmp1 Bmp1 Col28a1 Col28a1 Col18a1 Col18a1 P4ha2 P4ha2 Col11a2 Col11a2 Col20a1 Col20a1 P4ha3 P4ha3 Col9a2 Col9a2 P4hb P4hb Col6a6 Col6a6 Plod2 Plod2 Col4a1 Col4a1 Col4a2 Col4a2 Col26a1 Col26a1 Adamts3 Adamts3 Col8a1 Col8a1 Col4a5 Col4a5 Tll1 Tll1 Col16a1 Col16a1 Col11a1 Col11a1 Adamts14 Adamts14 LOC103693323 LOC103693323 Col14a1 Col14a1 P4ha1 P4ha1 Col25a1 Col25a1 PCOLCE2 PCOLCE2 LOC102555086 LOC102555086 Col6a5 Col6a5 LOC100909752 LOC100909752 Col2a1 Col2a1 P3h1 P3h1 Col13a1 Col13a1 Col17a1 Col17a1 Col4a6 Col4a6 Pcolce Pcolce Col10a1 Col10a1 P3h2 P3h2 Adamts2 Adamts2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Col6a2Procollagen, type VI, alpha 2, isoform CRA_a. (1027 aa)
Plod3Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3; Multifunctional enzyme that catalyzes a series of post- translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosy [...] (741 aa)
Col3a1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity). (1463 aa)
Col5a2Collagen type V alpha 2 chain. (1494 aa)
Col1a1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1453 aa)
Col27a1Collagen alpha-1(XXVII) chain; Plays a role during the calcification of cartilage and the transition of cartilage to bone. (1855 aa)
Plod1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity). (728 aa)
Col5a1Collagen alpha-1(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (By similarity). (1840 aa)
Col9a3Collagen type IX alpha 3 chain. (680 aa)
Col8a2Collagen type VIII alpha 2 chain. (699 aa)
Col1a2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1372 aa)
Col19a1Collagen type XIX alpha 1 chain. (1129 aa)
Tll2Metalloendopeptidase. (1014 aa)
Col24a1Collagen type XXIV alpha 1 chain. (1352 aa)
P3h3Leprecan-like 2 (Predicted), isoform CRA_b. (548 aa)
PpibPeptidyl-prolyl cis-trans isomerase B; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase B subfamily. (216 aa)
Serpinh1Serpin H1; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. (417 aa)
Colgalt1Glycosyltransferase 25 domain containing 1 (Predicted). (617 aa)
Col5a3Procollagen, type V, alpha 3, isoform CRA_b. (1737 aa)
Col7a1Procollagen, type VII, alpha 1 (Predicted). (2588 aa)
Col22a1Collagen type XXII alpha 1 chain. (1613 aa)
Colgalt2Collagen beta(1-O)galactosyltransferase 2. (624 aa)
Bmp1Metalloendopeptidase. (990 aa)
Col28a1Collagen type XXVIII alpha 1 chain. (1142 aa)
Col18a1Procollagen, type XVIII, alpha 1, isoform CRA_a. (1311 aa)
P4ha2Prolyl 4-hydroxylase subunit alpha 2. (535 aa)
Col11a2Procollagen, type XI, alpha 2 (Mapped). (1650 aa)
Col20a1Collagen type XX alpha 1 chain. (1362 aa)
P4ha3Prolyl 4-hydroxylase subunit alpha-3; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. (544 aa)
Col9a2Procollagen, type IX, alpha 2 (Predicted). (688 aa)
P4hbProtein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chape [...] (509 aa)
Col6a6Collagen type VI alpha 6 chain. (2264 aa)
Plod2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. (758 aa)
Col4a1Collagen type IV alpha 1 chain. (1669 aa)
Col4a2Collagen type IV alpha 2 chain. (1645 aa)
Col26a1Collagen type XXVI alpha 1 chain. (440 aa)
Adamts3ADAM metallopeptidase with thrombospondin type 1, motif 3. (910 aa)
Col8a1Collagen type VIII alpha 1 chain. (744 aa)
Col4a5Collagen type IV alpha 5 chain. (1691 aa)
Tll1Metalloendopeptidase. (1012 aa)
Col16a1Collagen type XVI alpha 1 chain. (1618 aa)
Col11a1Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. (1804 aa)
Adamts14ADAM metallopeptidase with thrombospondin type 1 motif, 14. (1125 aa)
LOC103693323Collagen alpha-1(XXIII) chain. (532 aa)
Col14a1Collagen type XIV alpha 1 chain. (1794 aa)
P4ha1Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. (534 aa)
Col25a1Collagen type XXV alpha 1 chain. (503 aa)
PCOLCE2Procollagen C-endopeptidase enhancer 2. (370 aa)
LOC102555086Similar to Cartilage-associated protein (Predicted), isoform CRA_b. (403 aa)
Col6a5Collagen type VI alpha 5 chain. (2632 aa)
LOC100909752Procollagen, type XV, isoform CRA_a. (1345 aa)
Col2a1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1419 aa)
P3h1Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity). (739 aa)
Col13a1Similar to alpha 1 type XIII collagen isoform 17, isoform CRA_a. (739 aa)
Col17a1Collagen type XVII alpha 1 chain. (1465 aa)
Col4a6Collagen type IV alpha 6 chain. (1638 aa)
PcolceProcollagen C-endopeptidase enhancer 1; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. (493 aa)
Col10a1Collagen type X alpha 1 chain. (680 aa)
P3h2Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens. Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position (By similarity). Belongs to the leprecan family. (702 aa)
Adamts2ADAM metallopeptidase with thrombospondin type 1 motif, 2. (1170 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.