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Chm Chm Rabgef1 Rabgef1 Trappc5 Trappc5 Ccz1b Ccz1b Rab21 Rab21 Trappc6b Trappc6b Ywhae Ywhae Rab3ip Rab3ip Rab7b Rab7b Rab39a Rab39a Sbf2 Sbf2 Trappc3 Trappc3 Dennd3 Dennd3 Trappc4 Trappc4 Dennd6a Dennd6a Dennd4a Dennd4a Rab27b Rab27b Rab7a Rab7a Trappc13 Trappc13 Dennd5a Dennd5a Rab32 Rab32 Trappc2l Trappc2l Rab8a Rab8a Trappc8 Trappc8 Ric1 Ric1 Rgp1 Rgp1 Rab38 Rab38 Trappc6a Trappc6a Dennd2d Dennd2d Rab8b Rab8b Gdi2 Gdi2 Mon1a Mon1a Rab6a Rab6a Akt2 Akt2 Rab14 Rab14 Rab18 Rab18 Rab3a Rab3a Rin1 Rin1 Rab3il1 Rab3il1 Rab35 Rab35 Trappc12 Trappc12 Trappc10 Trappc10 Rab5c Rab5c Dennd2a Dennd2a Akt1 Akt1 Rab3gap2 Rab3gap2 Trappc9 Trappc9 Dennd1b Dennd1b Als2cl Als2cl Dennd6b Dennd6b Dennd4b Dennd4b Rab9a Rab9a Ulk1 Ulk1 Rab5b Rab5b Rin2 Rin2 Rab12 Rab12 Dennd2b Dennd2b Mon1b Mon1b Trappc2 Trappc2 Rab31 Rab31 Gapvd1 Gapvd1 Dennd5b Dennd5b Rab10 Rab10 Rab9b Rab9b Sbf1 Sbf1 Dennd1c Dennd1c Rab1b Rab1b Rab6b Rab6b Dennd2c Dennd2c Rab27a Rab27a Ankrd27 Ankrd27 Gdi1 Gdi1 Rab3gap1 Rab3gap1 Akt3 Akt3 Hps1 Hps1 Dennd4c Dennd4c Rin3 Rin3 Rab13 Rab13 Trappc11 Trappc11 Hps4 Hps4 Als2 Als2 Rinl Rinl Dennd1a Dennd1a Madd Madd Trappc1 Trappc1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ChmRab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] (647 aa)
Rabgef1RAB guanine nucleotide exchange factor (GEF) 1 (Predicted), isoform CRA_a. (502 aa)
Trappc5Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (188 aa)
Ccz1bCCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. (480 aa)
Rab21Ras-related protein Rab-21; Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (By similarity). Involved in neurite growth. Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal tran [...] (223 aa)
Trappc6bTrafficking protein particle complex 6B (Predicted). (158 aa)
Ywhae14-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. (255 aa)
Rab3ipRab-3A-interacting protein; Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (By similarity). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apic [...] (460 aa)
Rab7bSimilar to RAB7-like protein (Predicted), isoform CRA_b. (199 aa)
Rab39aRAB39, member RAS oncogene family (Predicted). (217 aa)
Sbf2SET-binding factor 2. (1826 aa)
Trappc3Trafficking protein particle complex subunit 3; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (180 aa)
Dennd3DENN domain-containing 3. (1278 aa)
Trappc4Trafficking protein particle complex subunit 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (219 aa)
Dennd6aDENN domain-containing 6A. (602 aa)
Dennd4aDENN domain-containing 4A. (1873 aa)
Rab27bRas-related protein Rab-27B; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1. May be involved in targeting uroplakins to urothelial apical membranes. (218 aa)
Rab7aRas-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (207 aa)
Trappc13Trafficking protein particle complex subunit 13. (418 aa)
Dennd5aDENN domain-containing protein 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth. (1287 aa)
Rab32Similar to RAB32 (Predicted), isoform CRA_a. (223 aa)
Trappc2lTrafficking protein particle complex subunit 2-like protein; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (139 aa)
Rab8aRas-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa)
Trappc8Trafficking protein particle complex 8. (1433 aa)
Ric1RIC1 homolog, RAB6A GEF complex partner 1. (1423 aa)
Rgp1RGP1 homolog, RAB6A GEF complex partner 1. (391 aa)
Rab38Rab38, member of RAS oncogene family. (211 aa)
Trappc6aTrafficking protein particle complex 6A. (174 aa)
Dennd2dDENN/MADD domain containing 2D (Predicted). (466 aa)
Rab8bRas-related protein Rab-8B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells. (207 aa)
Gdi2Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. (445 aa)
Mon1aMON1 homolog A, secretory-trafficking-associated. (555 aa)
Rab6aRas-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER. Belongs to the small GTPase superfamily. Rab family. (208 aa)
Akt2RAC-beta serine/threonine-protein kinase; AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinases, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the [...] (481 aa)
Rab14Ras-related protein Rab-14; Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B [...] (215 aa)
Rab18Ras-related protein Rab-18; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity). (206 aa)
Rab3aRas-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed. Stimulates insulin secretion through in [...] (220 aa)
Rin1Ras and Rab interactor 1; Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis (By similarity). Belongs to the RIN (Ras int [...] (798 aa)
Rab3il1Guanine nucleotide exchange factor for Rab-3A; Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activates RAB8A and RAB8B (By similarity); Belongs to the SEC2 family. (376 aa)
Rab35Ras-related protein Rab-35; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required f [...] (201 aa)
Trappc12Trafficking protein particle complex 12. (797 aa)
Trappc10Trafficking protein particle complex 10. (1259 aa)
Rab5cRas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (216 aa)
Dennd2aDENN domain-containing 2A. (998 aa)
Akt1RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the [...] (480 aa)
Rab3gap2Rab3 GTPase-activating protein non-catalytic subunit; Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. (1389 aa)
Trappc9Trafficking protein particle complex 9. (1139 aa)
Dennd1bDENN domain-containing 1B. (760 aa)
Als2clALS2 C-terminal-like. (952 aa)
Dennd6bDENN domain-containing 6B. (585 aa)
Dennd4bDENN domain-containing 4B. (1503 aa)
Rab9aRas-related protein Rab-9A; Involved in the transport of proteins between the endosomes and the trans-Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. (201 aa)
Ulk1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1051 aa)
Rab5bRAB5B, member RAS oncogene family (Predicted), isoform CRA_c. (215 aa)
Rin2Ras and Rab interactor 2 (Predicted), isoform CRA_c. (902 aa)
Rab12Ras-related protein Rab-12; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By simi [...] (245 aa)
Dennd2bSuppression of tumorigenicity 5 (Predicted), isoform CRA_a. (1100 aa)
Mon1bMON1 homolog b (Yeast) (Predicted), isoform CRA_b. (438 aa)
Trappc2Trafficking protein particle complex subunit 2. (140 aa)
Rab31Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] (195 aa)
Gapvd1GTPase-activating protein and VPS9 domains 1. (1484 aa)
Dennd5bUncharacterized protein. (977 aa)
Rab10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...] (200 aa)
Rab9bRAB9B, member RAS oncogene family. (201 aa)
Sbf1SET-binding factor 1. (1893 aa)
Dennd1cDENN/MADD domain containing 1C. (786 aa)
Rab1bRas-related protein Rab-1B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates [...] (201 aa)
Rab6bRAB6B, member RAS oncogene family. (208 aa)
Dennd2cDENN domain-containing 2C. (923 aa)
Rab27aRas-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. (221 aa)
Ankrd27Ankyrin repeat domain 27. (1055 aa)
Gdi1Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. (447 aa)
Rab3gap1Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. (769 aa)
Akt3RAC-gamma serine/threonine-protein kinase; AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial fo [...] (474 aa)
Hps1HPS1, biogenesis of lysosomal organelles complex 3 subunit 1. (706 aa)
Dennd4cDENN domain-containing 4C. (1901 aa)
Rin3Ras and Rab interactor 3. (980 aa)
Rab13Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regu [...] (203 aa)
Trappc11Trafficking protein particle complex 11. (1193 aa)
Hps4HPS4, biogenesis of lysosomal organelles complex 3 subunit 2. (700 aa)
Als2Alsin; May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons. (1651 aa)
RinlSimilar to RIKEN cDNA 5830482F20 gene (Predicted). (568 aa)
Dennd1aDENN domain-containing 1A. (1093 aa)
MaddMAP kinase-activating death domain protein; Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Converts GDP- bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis). (1627 aa)
Trappc1Trafficking protein particle complex subunit 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (145 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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