STRINGSTRING
Tap2 Tap2 Tap1 Tap1 RT1-M3-1 RT1-M3-1 RT1-N3 RT1-N3 RT1-S3 RT1-S3 Sec31a Sec31a Calr Calr Sec23a Sec23a Sar1b Sar1b Sec24c Sec24c Erap1 Erap1 Sec13 Sec13 Pdia3 Pdia3 B2m B2m Hspa5 Hspa5 RT1-M4 RT1-M4 Sec24b Sec24b RT1-CE10 RT1-CE10 Canx Canx RT1-CE1 RT1-CE1 RT1-M2 RT1-M2 F1M9F3_RAT F1M9F3_RAT Tapbp Tapbp RT1-M5 RT1-M5 RT1-M6-2 RT1-M6-2 RT1-CE3 RT1-CE3 RT1-N2 RT1-N2 RT1-CE5 RT1-CE5 RT1-CE7 RT1-CE7 Sec24d Sec24d RT1-CE4 RT1-CE4 Sec24a Sec24a Bcap31 Bcap31 RT1-M6-1 RT1-M6-1 RT1-A RT1-A RT1-CE12 RT1-CE12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tap2Antigen peptide transporter 2; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity). (703 aa)
Tap1Antigen peptide transporter 1; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity). (725 aa)
RT1-M3-1RT1 class Ib, locus M3, isoform CRA_a; Belongs to the MHC class I family. (339 aa)
RT1-N3RT1 class Ib gene, H2-TL-like, grc region (N3); Belongs to the MHC class I family. (393 aa)
RT1-S3RT1 class Ib, locus S3; Belongs to the MHC class I family. (365 aa)
Sec31aProtein transport protein Sec31A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. (1249 aa)
CalrCalreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. (416 aa)
Sec23aProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
Sar1bGTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity). (198 aa)
Sec24cSEC24 homolog C, COPII coat complex component. (1095 aa)
Erap1Endoplasmic reticulum aminopeptidase 1; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play [...] (930 aa)
Sec13Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum; Belongs to the WD repeat SEC13 family. (322 aa)
Pdia3Protein disulfide-isomerase A3. (510 aa)
B2mBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
Hspa5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (654 aa)
RT1-M4RT1 class Ib, locus M4; Belongs to the MHC class I family. (341 aa)
Sec24bSEC24 related gene family, member B (S. cerevisiae) (Predicted). (1242 aa)
RT1-CE10RT1 class I, locus CE10; Belongs to the MHC class I family. (367 aa)
CanxCalnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] (591 aa)
RT1-CE1RT1 class I, locus1; Belongs to the MHC class I family. (375 aa)
RT1-M2RT1 class Ib, locus M2; Belongs to the MHC class I family. (344 aa)
F1M9F3_RATIGc1 domain-containing protein; Belongs to the MHC class I family. (330 aa)
TapbpTap-binding protein (Tapasin). (464 aa)
RT1-M5RT1 class Ib, locus M5; Belongs to the MHC class I family. (357 aa)
RT1-M6-2RT1 class I, locus M6, gene 2; Belongs to the MHC class I family. (332 aa)
RT1-CE3RT1 class I, locus CE3; Belongs to the MHC class I family. (352 aa)
RT1-N2RCG41803, isoform CRA_a; Belongs to the MHC class I family. (377 aa)
RT1-CE5RT1 class I, locus CE5; Belongs to the MHC class I family. (375 aa)
RT1-CE7RT1 class I, locus CE7; Belongs to the MHC class I family. (355 aa)
Sec24dSEC24 homolog D, COPII coat complex component. (1033 aa)
RT1-CE4RT1 class I, locus CE4; Belongs to the MHC class I family. (373 aa)
Sec24aSEC24 related gene family, member A (S. cerevisiae) (Predicted). (1089 aa)
Bcap31B-cell receptor-associated protein 31, isoform CRA_a. (245 aa)
RT1-M6-1RT1 class I, locus M6, gene 1; Belongs to the MHC class I family. (372 aa)
RT1-ART1 class Ia, locus A1; Belongs to the MHC class I family. (382 aa)
RT1-CE12Ig-like domain-containing protein; Belongs to the MHC class I family. (371 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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