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Kif18b Kif18b Kif20a Kif20a Klc4 Klc4 Kif1a Kif1a Tuba3b Tuba3b Kif1c Kif1c Klc2 Klc2 Kif20b Kif20b Klc1 Klc1 Klc3 Klc3 Kifc1 Kifc1 Kif28p Kif28p Tuba8 Tuba8 Tubb4a Tubb4a Tubb1 Tubb1 Racgap1 Racgap1 Tuba1c Tuba1c Tuba1b Tuba1b Kif15 Kif15 Kifap3 Kifap3 Kif5a Kif5a Tubb2a Tubb2a Kif11 Kif11 Kif4a Kif4a Kif1b Kif1b Kif27 Kif27 Kifc2 Kifc2 Tuba1a Tuba1a Kif13b Kif13b Kif2b Kif2b Kif19 Kif19 Tuba4a Tuba4a Kif18a Kif18a Kif3a Kif3a Kif12 Kif12 Kif21b Kif21b Kif3b Kif3b Kif6 Kif6 Kif3c Kif3c Kif26b Kif26b Kif26a Kif26a Kif2a Kif2a Tubb3 Tubb3 Tubb2b Tubb2b Kif5b Kif5b Tubb6 Tubb6 Kif2c Kif2c Kif22 Kif22 Kif9 Kif9 Kif16b Kif16b Tubal3 Tubal3 Kif21a Kif21a Cenpe Cenpe Kif23 Kif23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Kif18bKinesin-like protein KIF18B; In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity). (826 aa)
Kif20aKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (888 aa)
Klc4Kinesin light chain 4; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). (619 aa)
Kif1aKinesin-like protein KIF1A; Motor for anterograde axonal transport of synaptic vesicle precursors (Probable). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites ; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. (1707 aa)
Tuba3bDetyrosinated tubulin alpha-3 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
Kif1cKinesin-like protein KIF1C; Probable motor protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. (1097 aa)
Klc2Kinesin light chain 2 (Predicted), isoform CRA_b. (622 aa)
Kif20bKinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1773 aa)
Klc1Kinesin light chain 1; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. (542 aa)
Klc3Kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. (505 aa)
Kifc1Kinesin-like protein KIFC1; Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. Regulates cilium formation and structure. (693 aa)
Kif28pKinesin-like protein KIF28P; Microtubule-dependent motor protein required for mitochondrion morhology and transport of mitochondria in neuronal cells; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1034 aa)
Tuba8Tubulin alpha-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (449 aa)
Tubb4aTubulin beta-4B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). (444 aa)
Tubb1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
Racgap1Rac GTPase-activating protein 1 (Predicted). (626 aa)
Tuba1cDetyrosinated tubulin alpha-1C chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
Tuba1bDetyrosinated tubulin alpha-1B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
Kif15Kinesin-like protein KIF15; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. (1385 aa)
Kifap3Kinesin-associated protein 3. (773 aa)
Kif5aKinesin heavy chain isoform 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. (1027 aa)
Tubb2aTubulin beta-2A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Belongs to the tubulin family. (445 aa)
Kif11Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1056 aa)
Kif4aKinesin family member 4A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1231 aa)
Kif1bKinesin-like protein KIF1B; Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. (1816 aa)
Kif27Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis. (1394 aa)
Kifc2Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (791 aa)
Tuba1aDetyrosinated tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
Kif13bKinesin family member 13B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1843 aa)
Kif2bKinesin-like protein KIF2B; Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromosome congression. (664 aa)
Kif19Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (995 aa)
Tuba4aTubulin alpha-4A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Belongs to the tubulin family. (448 aa)
Kif18aKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (811 aa)
Kif3aKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (702 aa)
Kif12Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (648 aa)
Kif21bKinesin-like protein KIF21B; Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1634 aa)
Kif3bKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (747 aa)
Kif6Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (746 aa)
Kif3cKinesin-like protein KIF3C; Microtubule-based anterograde translocator for membranous organelles. (796 aa)
Kif26bKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2118 aa)
Kif26aKinesin family member 26A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1873 aa)
Kif2aKinesin-like protein KIF2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily. (704 aa)
Tubb3Tubulin beta-3 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and maintenance (By similarity). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Plays a role in dorsal root ganglion axon projection towards the spinal cord (By similarity). (450 aa)
Tubb2bTubulin beta-2B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration (By similarity); Belongs to the tubulin family. (445 aa)
Kif5bKinesin-1 heavy chain; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. (963 aa)
Tubb6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (447 aa)
Kif2cKinesin-like protein KIF2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome- microtubule attachment. (721 aa)
Kif22Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (657 aa)
Kif9Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (790 aa)
Kif16bKinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1311 aa)
Tubal3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (382 aa)
Kif21aKinesin family member 21A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1658 aa)
CenpeCentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2439 aa)
Kif23Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (944 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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